‘Prion‐like’ propagation of the synucleinopathy of M83 transgenic mice depends on the mouse genotype and type of inoculum

The M83 transgenic mouse is a model of human synucleinopathies that develops severe motor impairment correlated with accumulation of the pathological Ser129‐phosphorylated α‐synuclein (α‐synP) in the brain and spinal cord. M83 disease can be accelerated by intracerebral inoculation of brain extracts...

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Veröffentlicht in:	Journal of neurochemistry 2017-10, Vol.143 (1), p.126-135
Hauptverfasser:	Sargent, Dorian, Verchère, Jérémy, Lazizzera, Corinne, Gaillard, Damien, Lakhdar, Latifa, Streichenberger, Nathalie, Morignat, Eric, Bétemps, Dominique, Baron, Thierry
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult alpha-Synuclein - genetics Animals Atrophy Brain Central nervous system Enzyme-linked immunosorbent assay Female Fibrils Genotype Humans Immunoreactivity Inoculation Inoculation route Inoculum Male Membrane Glycoproteins - genetics Mice Mice, 129 Strain Mice, Inbred C3H Mice, Transgenic multiple system atrophy Multiple System Atrophy - genetics Multiple System Atrophy - physiopathology Neonates Parkinson's disease Peritoneum prion Prion Proteins - genetics Propagation Rodents Spinal cord Synuclein transgenic Transgenic mice α‐synuclein
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