Impact of Coxsackievirus A6 emergence on hand, foot, and mouth disease epidemic in Osaka City, Japan
Hand, foot, and mouth disease (HFMD) is an acute febrile illness characterized by fever; sore throat; and vesicular eruptions on the hands, feet, and oral mucosa. Until 2010, HFMD was predominantly associated with enterovirus (EV) A71 and coxsackievirus (CV) A16 in Japan. In 2011, CV‐A6 emerged as a...
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| Veröffentlicht in: | Journal of medical virology 2017-12, Vol.89 (12), p.2116-2121 |
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| creator | Kanbayashi, Daiki Kaida, Atsushi Yamamoto, Seiji P. Hirai, Yuki Kubo, Hideyuki Fujimori, Ryoko Hakui, Noritaka Hirokawa, Hidetetsu Iritani, Nobuhiro |
| description | Hand, foot, and mouth disease (HFMD) is an acute febrile illness characterized by fever; sore throat; and vesicular eruptions on the hands, feet, and oral mucosa. Until 2010, HFMD was predominantly associated with enterovirus (EV) A71 and coxsackievirus (CV) A16 in Japan. In 2011, CV‐A6 emerged as a primary causative agent, causing the largest HFMD epidemic in Japan since 1981. Since then, CV‐A6 has caused large HFMD epidemics every 2 years. The phylogenetic analysis of complete Viral Protein 1 (VP1) sequences revealed that most CV‐A6 strains detected from 2011 to 2015 in Osaka City were classified into a different clade compared with CV‐A6 strains detected from 1999 until 2009. The majority of CV‐A6 strains detected in 2011 and most CV‐A6 strains detected from 2013 to 2015 were mainly divided into two distinct genetic groups. Each epidemic strain carried unique amino acid substitutions in the presumed DE, EF, and GH loops of the VP1 protein that is exposed on the surface of the virion. There is a possibility that the appearance of substitutions on the surface of the virion and an accumulation of a susceptible population are significant factors in recent HFMD epidemics. |
| doi_str_mv | 10.1002/jmv.24905 |
| format | Article |
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Until 2010, HFMD was predominantly associated with enterovirus (EV) A71 and coxsackievirus (CV) A16 in Japan. In 2011, CV‐A6 emerged as a primary causative agent, causing the largest HFMD epidemic in Japan since 1981. Since then, CV‐A6 has caused large HFMD epidemics every 2 years. The phylogenetic analysis of complete Viral Protein 1 (VP1) sequences revealed that most CV‐A6 strains detected from 2011 to 2015 in Osaka City were classified into a different clade compared with CV‐A6 strains detected from 1999 until 2009. The majority of CV‐A6 strains detected in 2011 and most CV‐A6 strains detected from 2013 to 2015 were mainly divided into two distinct genetic groups. Each epidemic strain carried unique amino acid substitutions in the presumed DE, EF, and GH loops of the VP1 protein that is exposed on the surface of the virion. There is a possibility that the appearance of substitutions on the surface of the virion and an accumulation of a susceptible population are significant factors in recent HFMD epidemics.</description><identifier>ISSN: 0146-6615</identifier><identifier>EISSN: 1096-9071</identifier><identifier>DOI: 10.1002/jmv.24905</identifier><identifier>PMID: 28771766</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Amino acids ; Coxsackieviruses ; Disease Outbreaks ; Enterovirus A, Human - classification ; Enterovirus A, Human - genetics ; Enterovirus A, Human - isolation & purification ; enteroviruses ; Epidemics ; Epidemiological Monitoring ; Eruptions ; Feet ; Fever ; Genotype ; Hand, Foot and Mouth Disease - diagnosis ; Hand, Foot and Mouth Disease - epidemiology ; Hand, Foot and Mouth Disease - virology ; Hand-foot-and-mouth disease ; Humans ; Japan - epidemiology ; Mucosa ; Pharyngitis ; Pharynx ; phylogenetic analysis ; Phylogeny ; Skin eruptions ; viral protein 1 ; Viral Proteins - genetics ; Virions ; Virology ; VP1 protein</subject><ispartof>Journal of medical virology, 2017-12, Vol.89 (12), p.2116-2121</ispartof><rights>2017 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4195-7cf5c34105736f1718a3b065b64e737a302e4747b309890c2e525d6efce0bf8e3</citedby><cites>FETCH-LOGICAL-c4195-7cf5c34105736f1718a3b065b64e737a302e4747b309890c2e525d6efce0bf8e3</cites><orcidid>0000-0002-9526-2411</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmv.24905$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmv.24905$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28771766$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kanbayashi, Daiki</creatorcontrib><creatorcontrib>Kaida, Atsushi</creatorcontrib><creatorcontrib>Yamamoto, Seiji P.</creatorcontrib><creatorcontrib>Hirai, Yuki</creatorcontrib><creatorcontrib>Kubo, Hideyuki</creatorcontrib><creatorcontrib>Fujimori, Ryoko</creatorcontrib><creatorcontrib>Hakui, Noritaka</creatorcontrib><creatorcontrib>Hirokawa, Hidetetsu</creatorcontrib><creatorcontrib>Iritani, Nobuhiro</creatorcontrib><title>Impact of Coxsackievirus A6 emergence on hand, foot, and mouth disease epidemic in Osaka City, Japan</title><title>Journal of medical virology</title><addtitle>J Med Virol</addtitle><description>Hand, foot, and mouth disease (HFMD) is an acute febrile illness characterized by fever; sore throat; and vesicular eruptions on the hands, feet, and oral mucosa. Until 2010, HFMD was predominantly associated with enterovirus (EV) A71 and coxsackievirus (CV) A16 in Japan. In 2011, CV‐A6 emerged as a primary causative agent, causing the largest HFMD epidemic in Japan since 1981. Since then, CV‐A6 has caused large HFMD epidemics every 2 years. The phylogenetic analysis of complete Viral Protein 1 (VP1) sequences revealed that most CV‐A6 strains detected from 2011 to 2015 in Osaka City were classified into a different clade compared with CV‐A6 strains detected from 1999 until 2009. The majority of CV‐A6 strains detected in 2011 and most CV‐A6 strains detected from 2013 to 2015 were mainly divided into two distinct genetic groups. Each epidemic strain carried unique amino acid substitutions in the presumed DE, EF, and GH loops of the VP1 protein that is exposed on the surface of the virion. There is a possibility that the appearance of substitutions on the surface of the virion and an accumulation of a susceptible population are significant factors in recent HFMD epidemics.</description><subject>Amino acids</subject><subject>Coxsackieviruses</subject><subject>Disease Outbreaks</subject><subject>Enterovirus A, Human - classification</subject><subject>Enterovirus A, Human - genetics</subject><subject>Enterovirus A, Human - isolation & purification</subject><subject>enteroviruses</subject><subject>Epidemics</subject><subject>Epidemiological Monitoring</subject><subject>Eruptions</subject><subject>Feet</subject><subject>Fever</subject><subject>Genotype</subject><subject>Hand, Foot and Mouth Disease - diagnosis</subject><subject>Hand, Foot and Mouth Disease - epidemiology</subject><subject>Hand, Foot and Mouth Disease - virology</subject><subject>Hand-foot-and-mouth disease</subject><subject>Humans</subject><subject>Japan - epidemiology</subject><subject>Mucosa</subject><subject>Pharyngitis</subject><subject>Pharynx</subject><subject>phylogenetic analysis</subject><subject>Phylogeny</subject><subject>Skin eruptions</subject><subject>viral protein 1</subject><subject>Viral Proteins - genetics</subject><subject>Virions</subject><subject>Virology</subject><subject>VP1 protein</subject><issn>0146-6615</issn><issn>1096-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10EtLxDAUhuEgio6XhX9AAm4UpuNJ2iTtUgavKLNRtyVNTzXjtKlNq86_NzrqQnCVLB5eDh8h-wwmDICfzOvXCU8yEGtkxCCTUQaKrZMRsERGUjKxRba9nwNAmnG-SbZ4qhRTUo5IeVW32vTUVXTq3r02zxZfbTd4eiop1tg9YmOQuoY-6aYc08q5fkzDl9Zu6J9oaT1qjxRbW2JtDbUNnXn9rOnU9ssxvdatbnbJRqUXHve-3x1yf352N72MbmYXV9PTm8gkLBORMpUwccJAqFhWTLFUxwVIUcgEVax0DBwTlagihizNwHAUXJQSK4NQVCnGO-Ro1W079zKg7_PaeoOLhW7QDT5nGZcyZSJVgR7-oXM3dE24LigBSaoCDup4pUznvO-wytvO1rpb5gzyz-nzMH3-NX2wB9_Foaix_JU_WwdwsgJvdoHL_0v59e3DKvkBUbKK_g</recordid><startdate>201712</startdate><enddate>201712</enddate><creator>Kanbayashi, Daiki</creator><creator>Kaida, Atsushi</creator><creator>Yamamoto, Seiji P.</creator><creator>Hirai, Yuki</creator><creator>Kubo, Hideyuki</creator><creator>Fujimori, Ryoko</creator><creator>Hakui, Noritaka</creator><creator>Hirokawa, Hidetetsu</creator><creator>Iritani, Nobuhiro</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9526-2411</orcidid></search><sort><creationdate>201712</creationdate><title>Impact of Coxsackievirus A6 emergence on hand, foot, and mouth disease epidemic in Osaka City, Japan</title><author>Kanbayashi, Daiki ; 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sore throat; and vesicular eruptions on the hands, feet, and oral mucosa. Until 2010, HFMD was predominantly associated with enterovirus (EV) A71 and coxsackievirus (CV) A16 in Japan. In 2011, CV‐A6 emerged as a primary causative agent, causing the largest HFMD epidemic in Japan since 1981. Since then, CV‐A6 has caused large HFMD epidemics every 2 years. The phylogenetic analysis of complete Viral Protein 1 (VP1) sequences revealed that most CV‐A6 strains detected from 2011 to 2015 in Osaka City were classified into a different clade compared with CV‐A6 strains detected from 1999 until 2009. The majority of CV‐A6 strains detected in 2011 and most CV‐A6 strains detected from 2013 to 2015 were mainly divided into two distinct genetic groups. Each epidemic strain carried unique amino acid substitutions in the presumed DE, EF, and GH loops of the VP1 protein that is exposed on the surface of the virion. There is a possibility that the appearance of substitutions on the surface of the virion and an accumulation of a susceptible population are significant factors in recent HFMD epidemics.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28771766</pmid><doi>10.1002/jmv.24905</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-9526-2411</orcidid></addata></record> |
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| subjects | Amino acids Coxsackieviruses Disease Outbreaks Enterovirus A, Human - classification Enterovirus A, Human - genetics Enterovirus A, Human - isolation & purification enteroviruses Epidemics Epidemiological Monitoring Eruptions Feet Fever Genotype Hand, Foot and Mouth Disease - diagnosis Hand, Foot and Mouth Disease - epidemiology Hand, Foot and Mouth Disease - virology Hand-foot-and-mouth disease Humans Japan - epidemiology Mucosa Pharyngitis Pharynx phylogenetic analysis Phylogeny Skin eruptions viral protein 1 Viral Proteins - genetics Virions Virology VP1 protein |
| title | Impact of Coxsackievirus A6 emergence on hand, foot, and mouth disease epidemic in Osaka City, Japan |
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