Mechanisms involved in the cytotoxic action of Brazilian propolis and caffeic acid against HEp‐2 cells and modulation of P‐glycoprotein activity

Objectives The effects of propolis and phenolic compounds (caffeic acid – Caf; dihydrocinnamic acid – Cin; p‐coumaric acid – Cou) in the same quantity found in our propolis sample were investigated on human laryngeal epidermoid carcinoma (HEp‐2) cells. Methods Cell viability, apoptosis/necrosis and...

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Veröffentlicht in:	Journal of pharmacy and pharmacology 2017-11, Vol.69 (11), p.1625-1633
Hauptverfasser:	Silva, Lívia M., Frión‐Herrera, Yahima, Bartolomeu, Ariane R., Gorgulho, Carolina Mendonça, Sforcin, José M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Animals Antineoplastic Agents, Phytogenic - pharmacology Apoptosis Apoptosis - drug effects ATP-Binding Cassette, Sub-Family B, Member 1 - drug effects ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism Brazil Caffeic acid Caffeic Acids - pharmacology Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - pathology Caspase Caspase-3 Cell cycle Cell Cycle Checkpoints - drug effects Cell Line, Tumor Cell Survival - drug effects Cercopithecus aethiops Coumaric acid Cytotoxicity Doxorubicin Doxorubicin - pharmacology Gangrene Gene expression Gene Expression Regulation, Neoplastic - drug effects HEp‐2 cells Humans Laryngeal Neoplasms - drug therapy Laryngeal Neoplasms - pathology Necrosis p-Coumaric acid P-Glycoprotein p53 Protein phenolic compounds Phenols Phenols - pharmacology Propolis Propolis - pharmacology Reactive oxygen species Reactive Oxygen Species - metabolism S phase Verapamil Verapamil - pharmacology Vero Cells
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