Vax1 Plays an Indirect Role in the Etiology of Murine Cleft Palate

Cleft lip with or without palate (CLP) and isolated cleft palate (CP) are common human developmental malformations with a complex etiology that reflects a failure of normal facial development. VAX1 encodes a homeobox-containing transcription factor identified as a candidate gene for CLP in human pop...

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Veröffentlicht in:	Journal of dental research 2017-12, Vol.96 (13), p.1555-1562
Hauptverfasser:	Geoghegan, F., Xavier, G.M., Birjandi, A.A., Seppala, M., Cobourne, M.T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Basal forebrain Cell cycle Cell Proliferation Cleft lip/palate Cleft Palate - genetics Clonal deletion Craniofacial growth Defects Dentistry Disease Models, Animal Ectoderm Embryos Etiology Forebrain Gene deletion Gene Expression Regulation, Developmental Genes Genotype & phenotype Hedgehog protein Holoprosencephaly Holoprosencephaly - genetics Homeobox Homeodomain Proteins - genetics Hypothalamus Labeling Mesenchyme Mice Morphology Neuroectoderm Neuropeptides - genetics Nose Phenotype Prosencephalon - abnormalities Scholarships & fellowships Signal Transduction Transcription Factors - genetics Transduction
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