Supra‐Additive Interaction of Docosahexaenoic Acid and Naproxen and Gastric Safety on the Formalin Test in Rats

ABSTRACT Preclinical Research The aim of this work was to evaluate the effect of docosahexaenoic acid (DHA) on the pharmacokinetics and pharmacodynamics—nociception—of naproxen in rats, as well as to determine the gastric safety resulting from this combination versus naproxen alone. Female Wistar ra...

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Veröffentlicht in:	Drug development research 2017-11, Vol.78 (7), p.332-339
Hauptverfasser:	Arroyo‐Lira, Arlette Guadalupe, Rodríguez‐Ramos, Fernando, Ortiz, Mario I., Castañeda‐Hernández, Gilberto, Chávez‐Piña, Aracely Evangelina
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals antinociception Bioavailability Docosahexaenoic acid Docosahexaenoic Acids - administration & dosage Docosahexaenoic Acids - pharmacokinetics Dose-Response Relationship, Drug Drug dosages Drug Synergism Drug Therapy, Combination Female Formaldehyde gastric injury Inflammation Injury analysis Male Naproxen Naproxen - administration & dosage Naproxen - pharmacokinetics Oral administration Pain Pain - drug therapy Pain Measurement - drug effects Pain perception Pharmacodynamics Pharmacokinetics Pharmacology Rats Rats, Wistar Rodents Safety Stomach - drug effects supra‐additive interaction
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