Influenza Virus Hemagglutinin Concentrates in Lipid Raft Microdomains for Efficient Viral Fusion

Lipid raft microdomains are enriched in sphingomyelin and cholesterol and function as platforms for signal transduction and as the site of budding of several enveloped viruses, including influenza virus. The influenza virus hemagglutinin (HA) glycoprotein, which mediates both viral-cell attachment a...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2003-12, Vol.100 (25), p.14610-14617
Hauptverfasser:	Takeda, Makoto, Leser, George P., Russell, Charles J., Lamb, Robert A.
Format:	Artikel
Sprache:	eng
Schlagworte:	AHA protein Amino Acid Sequence Animals Biological Sciences Budding Cell Fusion Cell Line Cell Line, Tumor Cell lines Cell Membrane - metabolism Cell Membrane - virology Cell membranes Cellular biology Cercopithecus aethiops Cholesterol Cholesterol - metabolism Detergents - pharmacology DNA, Complementary - metabolism Dogs Electrophoresis, Polyacrylamide Gel Epithelial cells Hemagglutinin Glycoproteins, Influenza Virus - biosynthesis Hemagglutinin Glycoproteins, Influenza Virus - physiology Hemagglutinins - biosynthesis Hemagglutinins - physiology Humans Immunoblotting Influenza Influenza virus Kinetics Lipid Metabolism Lipids Membrane Fusion Membrane Microdomains - metabolism Membrane Microdomains - virology Microbiology Microscopy, Electron Microscopy, Fluorescence Molecular Sequence Data Mutagenesis Mutation Octoxynol - pharmacology Orthomyxoviridae Orthomyxoviridae - genetics Orthomyxoviridae - metabolism Precipitin Tests Protein Structure, Tertiary Rafts Recombinant Fusion Proteins - metabolism Signal Transduction Vero Cells Virions Viruses
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