A Corepressor/Coactivator Exchange Complex Required for Transcriptional Activation by Nuclear Receptors and Other Regulated Transcription Factors

The mechanisms that control the precisely regulated switch from gene repression to gene activation represent a central question in mammalian development. Here, we report that transcriptional activation mediated by liganded nuclear receptors unexpectedly requires the actions of two highly related F b...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell 2004-02, Vol.116 (4), p.511-526
Hauptverfasser:	Perissi, Valentina, Aggarwal, Aneel, Glass, Christopher K, Rose, David W, Rosenfeld, Michael G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes - cytology Animals Cell Differentiation Cell Nucleus - metabolism Cells, Cultured Cysteine Endopeptidases - metabolism Embryo, Mammalian - cytology Endothelium, Vascular - cytology Gene Deletion Genetic Vectors Ligands Mice Microscopy, Fluorescence Models, Biological Models, Genetic Multienzyme Complexes - metabolism N-CoR protein Neurons - cytology NF-kappa B - metabolism Nuclear Proteins - metabolism Precipitin Tests Proteasome Endopeptidase Complex Protein Binding Proto-Oncogene Proteins c-jun - metabolism Receptors, Cytoplasmic and Nuclear - metabolism Repressor Proteins - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA - chemistry Signal Transduction SMRT protein Stem Cells - metabolism TBL1 gene TBLR1 gene Transcription Factors - metabolism Transcriptional Activation Transducin - metabolism Ubiquitin - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!