Activity of isosteviol lactone on mitochondrial metabolism

Isosteviol lactone (LAC), a lactone derivative of the diterpenic acid isosteviol (ISO) was evaluated for its effect on the oxidative metabolism of mitochondria isolated from rat liver. In this model, LAC (1 mM) depressed the phosphorylation efficiency, as shown by the decreased respiratory control c...

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Veröffentlicht in:	Toxicology letters 2003-06, Vol.143 (1), p.83-92
Hauptverfasser:	Braguini, Welligton L., Gomes, Maria A.Biazon, de Oliveira, Brás H., Carnieri, Eva G.S., Rocha, Maria Eliane M., de Oliveira, Maria Benigna M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cyclic voltammetry Diterpenes - chemical synthesis Diterpenes - chemistry Diterpenes - pharmacology Diterpenes, Kaurane Diterpenoids Electrochemistry Electron Transport - drug effects Electrophysiology Enzymes General pharmacology Hydrolysis In Vitro Techniques Isosteviol Isosteviol lactone Ketones - chemistry Lactones - chemistry Lactones - pharmacology Male Medical sciences Mitochondria Mitochondria, Liver - drug effects Mitochondria, Liver - enzymology Mitochondria, Liver - metabolism Mitochondrial Swelling - drug effects Oxidation-Reduction Oxidative Phosphorylation - drug effects Oxygen Consumption - drug effects Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Proteins - metabolism Rats Rats, Wistar Respiratory chain Stevia - chemistry Structure-Activity Relationship Swelling
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