TRF2 recruits the Werner syndrome (WRN) exonuclease for processing of telomeric DNA

The cancer-prone and premature aging disease Werner syndrome is due to loss of WRN gene function. Cells lacking WRN demonstrate genomic instability, including telomeric abnormalities and undergo premature senescence, suggesting defects in telomere metabolism. This notion is strongly supported by our...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Oncogene 2004-01, Vol.23 (1), p.149-156
Hauptverfasser:	Machwe, Amrita, Xiao, Liren, Orren, David K
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Apoptosis Base Sequence Biological and medical sciences Cancer Cell Biology Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes DNA - metabolism DNA Helicases - physiology Exodeoxyribonucleases Exonucleases - physiology Fundamental and applied biological sciences. Psychology Genotype & phenotype Human Genetics Internal Medicine Medicine Medicine & Public Health Metabolism Molecular and cellular biology Molecular Sequence Data Oncology original-paper RecQ Helicases Senescence Telomerase Telomere - metabolism Telomeric Repeat Binding Protein 1 - physiology Telomeric repeat binding protein 2 Telomeric Repeat Binding Protein 2 - physiology Toxicology Werner Syndrome - genetics Werner Syndrome Helicase Yeast
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!