Expression of the Arp11 gene suppresses the tumorigenicity of PC-14 human lung adenocarcinoma cells

We recently reported the isolation of a novel actin-related gene, Arp11, from a PC-14 human lung adenocarcinoma clone with low metastatic and tumorigenic ability. In this paper, we report the effect of Arp11 expression on PC-14 tumor growth. We transfected a highly metastatic and tumorigenic PC-14 l...

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Veröffentlicht in:	Biochemical and biophysical research communications 2003-12, Vol.312 (4), p.889-896
Hauptverfasser:	Shindo-Okada, Nobuko, Iigo, Masaaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin-related gene Actin-Related Protein 3 Actins - genetics Actins - metabolism Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma - pathology Animals Arp11 Arp11 gene Carcinogenicity Tests Cell Division Cell Line, Tumor Female Gene Expression Regulation, Neoplastic - physiology High-metastatic cells Human lung adenocarcinoma Humans Low-metastatic cells Lung cancer Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Mice Mice, Inbred BALB C Mice, Nude Mutation Neoplasm Transplantation PC-14 cells Suppressor gene Transcription, Genetic Transfectants Tumor suppressor
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