Doublecortin Microtubule Affinity Is Regulated by a Balance of Kinase and Phosphatase Activity at the Leading Edge of Migrating Neurons

Doublecortin (Dcx) is a microtubule-associated protein that is mutated in X-linked lissencephaly (X-LIS), a neuronal migration disorder associated with epilepsy and mental retardation. Although Dcx can bind ubiquitously to microtubules in nonneuronal cells, Dcx is highly enriched in the leading proc...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2004-01, Vol.41 (2), p.203-213
Hauptverfasser:	Schaar, Bruce T, Kinoshita, Kazuhisa, McConnell, Susan K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bands Cell culture Cell division Cell Membrane - enzymology Cell Membrane - metabolism Cell Movement - drug effects Cell Movement - physiology Cells, Cultured Cyclic AMP-Dependent Protein Kinases - metabolism Cyclin-Dependent Kinase 5 Cyclin-Dependent Kinases - metabolism Cyclin-Dependent Kinases - physiology Cytoskeleton Cytoskeleton - metabolism Enzyme Inhibitors - pharmacology Humans Immunohistochemistry Kinases Microtubule-Associated Proteins - metabolism Microtubule-Associated Proteins - physiology Microtubules - drug effects Microtubules - metabolism Migration Motility Mutation Mutation - physiology Nerve Tissue Proteins - biosynthesis Neurites - metabolism Neurons Neurons - enzymology Neurons - metabolism Neurons - physiology Neuropeptides - metabolism Neuropeptides - physiology Okadaic Acid - pharmacology Phosphoric Monoester Hydrolases - metabolism Phosphorylation Proteins Rats Rats, Sprague-Dawley Science programs Serine - genetics Spectrum analysis
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