Autoprotection against Acetaminophen Toxicity in Cultured Rat Hepatocytes: The Effect of Pretreatment and Growth Factors

: To evaluate the effect of acetaminophen pretreatment and growth factors on acetaminophen hepatotoxicity in cultured rat hepatocytes, rat hepatocytes in primary culture were exposed to acetaminophen 8 mM after pretreatment with either acetaminophen 1 mM, treatment with growth factors (EGF and HGF),...

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Veröffentlicht in:	Pharmacology & toxicology 2003-09, Vol.93 (3), p.135-141
Hauptverfasser:	Grunnet, Niels, Tygstrup, Niels, Dich, John
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen - metabolism Acetaminophen - toxicity Adenosine Triphosphate - metabolism Analgesics, Non-Narcotic - metabolism Analgesics, Non-Narcotic - toxicity Animals Benzoquinones - metabolism Biological and medical sciences Cell Cycle Proteins - metabolism Cell Division - drug effects Cells, Cultured chemoprotection Cytochrome P-450 CYP1A2 - metabolism DNA - metabolism Drug toxicity and drugs side effects treatment Glutathione - metabolism Glutathione S-Transferase pi Glutathione Transferase - metabolism Growth Substances - metabolism Growth Substances - pharmacology Imines - metabolism Isoenzymes - metabolism L-Lactate Dehydrogenase - metabolism Liver - drug effects Liver - metabolism Male Medical sciences Pharmacology. Drug treatments Rats Rats, Wistar Thymidine - metabolism Time Factors Toxicity: digestive system
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