Human Targets of Pseudomonas aeruginosa Pyocyanin

Pseudomonas aeruginosa produces copious amounts of the redoxactive tricyclic compound pyocyanin that kills competing microbes and mammalian cells, especially during cystic fibrosis lung infection. Cross-phylum susceptibility to pyocyanin suggests the existence of evolutionarily conserved physiologic...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2003-11, Vol.100 (24), p.14315-14320
Hauptverfasser:	Ran, Huimin, Hassett, Daniel J., Lau, Gee W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphatases Apoptosis - drug effects Biological Sciences Cell cycle Cell growth Cell Line Cystic fibrosis Drug Resistance, Fungal Electron Transport - drug effects Electrons Epithelial cells Fluorescence Genes, Bacterial Genes, Fungal - drug effects Humans In Vitro Techniques Inactivation Lungs Microbiology Oxidative stress Oxidative Stress - drug effects Pathogens Penicillin Pseudomonas aeruginosa Pseudomonas aeruginosa - pathogenicity Pyocyanine - toxicity Respiratory function Saccharomyces cerevisiae Saccharomyces cerevisiae - drug effects Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Sequence Deletion Vacuolar Proton-Translocating ATPases - genetics Vacuolar Proton-Translocating ATPases - metabolism Yeasts
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