The Deletion of GPR40/FFAR1 Signaling Damages Maternal Care and Emotional Function in Female Mice
The free fatty acid receptor 1 (GPR40/FFAR1) is activated by polyunsaturated fatty acids (PUFAs) such as docosahexaenoic acids (DHA). This receptor has been the focus of many studies regarding physiological functions of the central nervous system. PUFAs are essential for neuronal development and mai...
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| Veröffentlicht in: | Biological & pharmaceutical bulletin 2017/08/01, Vol.40(8), pp.1255-1259 |
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| creator | Aizawa, Fuka Ogaki, Yoshihiro Kyoya, Natsuki Nishinaka, Takashi Nakamoto, Kazuo Kurihara, Takashi Hirasawa, Akira Miyata, Atsuro Tokuyama, Shogo |
| description | The free fatty acid receptor 1 (GPR40/FFAR1) is activated by polyunsaturated fatty acids (PUFAs) such as docosahexaenoic acids (DHA). This receptor has been the focus of many studies regarding physiological functions of the central nervous system. PUFAs are essential for neuronal development and maintenance of neuronal function; thus, the decrease of PUFAs in the brain is closely related to the induction of psychiatric diseases associated with emotional disorder, such as anxiety, depression, and schizophrenia. However, details of the mechanisms remain unclear. In this study, we investigated changes of maternal and/or emotional behavior caused by a deficiency of GPR40/FFAR1 signaling. GPR40/FFAR1 deficient (FFAR1−/−) female mice exhibited impaired maternal care such as retrieving behaviors and an increased rate of neglect and infanticide when compared to wild type (WT) female mice. Furthermore, FFAR1−/− female mice showed increased time spent in the open arms in an elevated plus maze test, reduction of locomotor activity and social interaction behavior, and decreased sucrose intake, when compared to WT female mice. In conclusion, these findings suggest that PUFAs-GPR40/FFAR1 signaling might function, at least in part, as a regulatory factor of emotional and maternal behavior in mice. |
| doi_str_mv | 10.1248/bpb.b17-00082 |
| format | Article |
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This receptor has been the focus of many studies regarding physiological functions of the central nervous system. PUFAs are essential for neuronal development and maintenance of neuronal function; thus, the decrease of PUFAs in the brain is closely related to the induction of psychiatric diseases associated with emotional disorder, such as anxiety, depression, and schizophrenia. However, details of the mechanisms remain unclear. In this study, we investigated changes of maternal and/or emotional behavior caused by a deficiency of GPR40/FFAR1 signaling. GPR40/FFAR1 deficient (FFAR1−/−) female mice exhibited impaired maternal care such as retrieving behaviors and an increased rate of neglect and infanticide when compared to wild type (WT) female mice. Furthermore, FFAR1−/− female mice showed increased time spent in the open arms in an elevated plus maze test, reduction of locomotor activity and social interaction behavior, and decreased sucrose intake, when compared to WT female mice. In conclusion, these findings suggest that PUFAs-GPR40/FFAR1 signaling might function, at least in part, as a regulatory factor of emotional and maternal behavior in mice.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.b17-00082</identifier><identifier>PMID: 28769007</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>Animals ; Anxiety ; Behavior, Animal ; Brain ; Central nervous system ; Emotional behavior ; emotional damage ; Emotions ; Female ; free fatty acid receptor 1 ; Infanticide ; Locomotor activity ; Male ; Maternal Behavior ; Mental disorders ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Nervous system ; polyunsaturated fatty acid ; Polyunsaturated fatty acids ; Receptors, G-Protein-Coupled - genetics ; Rodents ; Schizophrenia ; Signal Transduction ; Social Behavior ; Sucrose ; Sugar</subject><ispartof>Biological and Pharmaceutical Bulletin, 2017/08/01, Vol.40(8), pp.1255-1259</ispartof><rights>2017 The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c702t-12fd7ce3e549d9bc9fa857cad559a835e416b39832e71eac271f5db040d37a23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1881,4022,27921,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28769007$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aizawa, Fuka</creatorcontrib><creatorcontrib>Ogaki, Yoshihiro</creatorcontrib><creatorcontrib>Kyoya, Natsuki</creatorcontrib><creatorcontrib>Nishinaka, Takashi</creatorcontrib><creatorcontrib>Nakamoto, Kazuo</creatorcontrib><creatorcontrib>Kurihara, Takashi</creatorcontrib><creatorcontrib>Hirasawa, Akira</creatorcontrib><creatorcontrib>Miyata, Atsuro</creatorcontrib><creatorcontrib>Tokuyama, Shogo</creatorcontrib><creatorcontrib>School of Pharmaceutical Sciences</creatorcontrib><creatorcontrib>bDepartment of Pharmacology</creatorcontrib><creatorcontrib>Kyoto University</creatorcontrib><creatorcontrib>aDepartment of Clinical Pharmacy</creatorcontrib><creatorcontrib>Graduate School of Medical and Dental Sciences</creatorcontrib><creatorcontrib>cDepartment of Genomic Drug Discovery Sciences</creatorcontrib><creatorcontrib>Kagoshima University</creatorcontrib><creatorcontrib>Kobe Gakuin University</creatorcontrib><title>The Deletion of GPR40/FFAR1 Signaling Damages Maternal Care and Emotional Function in Female Mice</title><title>Biological & pharmaceutical bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>The free fatty acid receptor 1 (GPR40/FFAR1) is activated by polyunsaturated fatty acids (PUFAs) such as docosahexaenoic acids (DHA). This receptor has been the focus of many studies regarding physiological functions of the central nervous system. PUFAs are essential for neuronal development and maintenance of neuronal function; thus, the decrease of PUFAs in the brain is closely related to the induction of psychiatric diseases associated with emotional disorder, such as anxiety, depression, and schizophrenia. However, details of the mechanisms remain unclear. In this study, we investigated changes of maternal and/or emotional behavior caused by a deficiency of GPR40/FFAR1 signaling. GPR40/FFAR1 deficient (FFAR1−/−) female mice exhibited impaired maternal care such as retrieving behaviors and an increased rate of neglect and infanticide when compared to wild type (WT) female mice. Furthermore, FFAR1−/− female mice showed increased time spent in the open arms in an elevated plus maze test, reduction of locomotor activity and social interaction behavior, and decreased sucrose intake, when compared to WT female mice. In conclusion, these findings suggest that PUFAs-GPR40/FFAR1 signaling might function, at least in part, as a regulatory factor of emotional and maternal behavior in mice.</description><subject>Animals</subject><subject>Anxiety</subject><subject>Behavior, Animal</subject><subject>Brain</subject><subject>Central nervous system</subject><subject>Emotional behavior</subject><subject>emotional damage</subject><subject>Emotions</subject><subject>Female</subject><subject>free fatty acid receptor 1</subject><subject>Infanticide</subject><subject>Locomotor activity</subject><subject>Male</subject><subject>Maternal Behavior</subject><subject>Mental disorders</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>Nervous system</subject><subject>polyunsaturated fatty acid</subject><subject>Polyunsaturated fatty acids</subject><subject>Receptors, G-Protein-Coupled - genetics</subject><subject>Rodents</subject><subject>Schizophrenia</subject><subject>Signal Transduction</subject><subject>Social Behavior</subject><subject>Sucrose</subject><subject>Sugar</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU1v1DAQhi0EosvCkSuyxIVLWn-u7WO1bRakVqCyd8txJluvkniJkwP_HidbFomDx_LM43fGrxH6SMk1ZULfVKfquqKqIIRo9gqtKBeqkIzK12hFDNXFhkp9hd6ldMyIIoy_RVdMq43JpxVy-2fAd9DCGGKPY4N3P54EuSnL2yeKf4ZD79rQH_Cd69wBEn50Iww5h7duAOz6Gt93cb6aU-XU-0Ul9LiEzrWAH4OH9-hN49oEH172NdqX9_vt1-Lh--7b9vah8HmosaCsqZUHDlKY2lTeNE5L5V0tpXGaSxB0U3GjOQNFwXmmaCPrighSc-UYX6MvZ9nTEH9NkEbbheShbV0PcUqWGia1kVqQjH7-Dz3GaX7VQm2Y4jqvNSrOlB9iSgM09jSEzg2_LSV2tt5m62223i7WZ_7Ti-pUdVBf6L9eZ2B3BnI1eNfGPlsL_3r7pKoQ22gZWURFlrWE6txMyjkYZgTjlGel7VnpmMb8LZdWbhiDb2EZTBCr53AZ8FL1z26w0PM_KyyqvA</recordid><startdate>2017</startdate><enddate>2017</enddate><creator>Aizawa, Fuka</creator><creator>Ogaki, Yoshihiro</creator><creator>Kyoya, Natsuki</creator><creator>Nishinaka, Takashi</creator><creator>Nakamoto, Kazuo</creator><creator>Kurihara, Takashi</creator><creator>Hirasawa, Akira</creator><creator>Miyata, Atsuro</creator><creator>Tokuyama, Shogo</creator><general>The Pharmaceutical Society of Japan</general><general>Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>2017</creationdate><title>The Deletion of GPR40/FFAR1 Signaling Damages Maternal Care and Emotional Function in Female Mice</title><author>Aizawa, Fuka ; 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This receptor has been the focus of many studies regarding physiological functions of the central nervous system. PUFAs are essential for neuronal development and maintenance of neuronal function; thus, the decrease of PUFAs in the brain is closely related to the induction of psychiatric diseases associated with emotional disorder, such as anxiety, depression, and schizophrenia. However, details of the mechanisms remain unclear. In this study, we investigated changes of maternal and/or emotional behavior caused by a deficiency of GPR40/FFAR1 signaling. GPR40/FFAR1 deficient (FFAR1−/−) female mice exhibited impaired maternal care such as retrieving behaviors and an increased rate of neglect and infanticide when compared to wild type (WT) female mice. Furthermore, FFAR1−/− female mice showed increased time spent in the open arms in an elevated plus maze test, reduction of locomotor activity and social interaction behavior, and decreased sucrose intake, when compared to WT female mice. In conclusion, these findings suggest that PUFAs-GPR40/FFAR1 signaling might function, at least in part, as a regulatory factor of emotional and maternal behavior in mice.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>28769007</pmid><doi>10.1248/bpb.b17-00082</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Anxiety Behavior, Animal Brain Central nervous system Emotional behavior emotional damage Emotions Female free fatty acid receptor 1 Infanticide Locomotor activity Male Maternal Behavior Mental disorders Mice Mice, Inbred C57BL Mice, Knockout Nervous system polyunsaturated fatty acid Polyunsaturated fatty acids Receptors, G-Protein-Coupled - genetics Rodents Schizophrenia Signal Transduction Social Behavior Sucrose Sugar |
| title | The Deletion of GPR40/FFAR1 Signaling Damages Maternal Care and Emotional Function in Female Mice |
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