Lamtor1 Is Critically Required for CD4 + T Cell Proliferation and Regulatory T Cell Suppressive Function

Mechanistic target of rapamycin complex (mTORC)1 integrates intracellular sufficiency of nutrients and regulates various cellular functions. Previous studies using mice with conditional knockout of mTORC1 component proteins (i.e., mTOR, Raptor, and Rheb) gave conflicting results on the roles of mTOR...

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Veröffentlicht in:The Journal of immunology (1950) 2017-09, Vol.199 (6), p.2008-2019
Hauptverfasser: Hosokawa, Takashi, Kimura, Tetsuya, Nada, Shigeyuki, Okuno, Tatsusada, Ito, Daisuke, Kang, Sujin, Nojima, Satoshi, Yamashita, Kazuya, Nakatani, Takeshi, Hayama, Yoshitomo, Kato, Yasuhiro, Kinehara, Yuhei, Nishide, Masayuki, Mikami, Norihisa, Koyama, Syohei, Takamatsu, Hyota, Okuzaki, Daisuke, Ohkura, Naganari, Sakaguchi, Shimon, Okada, Masato, Kumanogoh, Atsushi
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Sprache:eng
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