Enzymatic Synthesis of Psilocybin

Psilocybin is the psychotropic tryptamine‐derived natural product of Psilocybe carpophores, the so‐called “magic mushrooms”. Although its structure has been known for 60 years, the enzymatic basis of its biosynthesis has remained obscure. We characterized four psilocybin biosynthesis enzymes, namely...

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Veröffentlicht in:	Angewandte Chemie International Edition 2017-09, Vol.56 (40), p.12352-12355
Hauptverfasser:	Fricke, Janis, Blei, Felix, Hoffmeister, Dirk
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Hydroxytryptophan - chemistry Aromatic-L-Amino-Acid Decarboxylases - metabolism Biosynthesis Carpophores Catalysis Chemical synthesis Chromatography, Liquid - methods Enzymatic synthesis Enzymes Fungi Genes, Fungal Hallucinogens - metabolism kinases Mass Spectrometry - methods Methyltransferase Methyltransferases - metabolism Mixed Function Oxygenases - metabolism Monooxygenase Mushrooms natural products Psilocybe - enzymology Psilocybe - genetics Psilocybin Psilocybin - biosynthesis S-Adenosylmethionine - metabolism Substrate Specificity Tryptamine Tryptophan
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