Dynamic contrast-enhanced magnetic resonance imaging parameters correlate with advanced revised-ISS and angiopoietin-1/angiopoietin-2 ratio in patients with multiple myeloma
The aim of the study was to assess the value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in patients with newly diagnosed multiple myeloma (MM) who were treated with novel anti-myeloma agents. We studied 60 previously untreated MM patients at diagnosis, 14 with smoldering MM (S...
Gespeichert in:
| Veröffentlicht in: | Annals of hematology 2017-10, Vol.96 (10), p.1707-1714 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1714 |
|---|---|
| container_issue | 10 |
| container_start_page | 1707 |
| container_title | Annals of hematology |
| container_volume | 96 |
| creator | Terpos, Evangelos Matsaridis, Dimitris Koutoulidis, Vassilis Zagouri, Flora Christoulas, Dimitrios Fontara, Sophia Panourgias, Evangelia Gavriatopoulou, Maria Kastritis, Efstathios Dimopoulos, Meletios A. Moulopoulos, Lia A. |
| description | The aim of the study was to assess the value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in patients with newly diagnosed multiple myeloma (MM) who were treated with novel anti-myeloma agents. We studied 60 previously untreated MM patients at diagnosis, 14 with smoldering MM (SMM) and 5 with MGUS. All patients underwent MRI of the thoracolumbar spine and pelvis before the administration of any kind of therapy, and DCE-MRI was performed. The MRI perfusion parameters evaluated were wash-in (WIN), washout (WOUT), time-to-peak (TTPK), time-to-maximum slope (TMSP), and the WIN/TMSP ratio. The following serum levels of angiogenic cytokines were measured on the day of MRI: VEGF, angiogenin (Ang), angiopoietin-1 (Angp-1), and −2 (Angp-2). Symptomatic MM patients had increased WIN compared to SMM (
p
|
| doi_str_mv | 10.1007/s00277-017-3078-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1925511708</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1925511708</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-83ced2708b3a50fd8655e8963e6a5f428c25dc169c62ce23553734a52489003c3</originalsourceid><addsrcrecordid>eNp1kV1rFTEQhoMo9tj6A7yRgDfexOZjs8leSv0qFHpRe72k2TmnKbvJmmRbzo_yPzqHraJCAyHMzDPvDHkJeSP4B8G5OS2cS2MYF4Ypbiwzz8hGNEoyrm3znGx4pzqm8RyRV6XccS6kbeRLciStaVsMN-Tnp310U_DUp1izK5VBvHXRw0Ant4tQsZShpHjI0YC5EHd0dtlNUCEX7MsZRleBPoR6S91wv3ZnuA8FBnZ-dUVdHPDuQppTQMXIxOk_oaTZ1ZBoiKhcA8RaVrVpGWuYR6DTHsY0uRPyYuvGAq8f32Ny_eXz97Nv7OLy6_nZxwvmlZGVWYUbSMPtjXKabwfbag22axW0Tm8bab3Ugxdt51vpQSqtlVGN07KxHefKq2PyftWdc_qxQKn9FIqHcXQR0lJ60UmthcAJiL77D71LS464HVIKAculREqslM-plAzbfs74mXnfC94fvOxXL3v0sj942RvsefuovNxMMPzp-G0eAnIFCpbiDvJfo59U_QVrFqxE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1930838022</pqid></control><display><type>article</type><title>Dynamic contrast-enhanced magnetic resonance imaging parameters correlate with advanced revised-ISS and angiopoietin-1/angiopoietin-2 ratio in patients with multiple myeloma</title><source>MEDLINE</source><source>SpringerLink_现刊</source><creator>Terpos, Evangelos ; Matsaridis, Dimitris ; Koutoulidis, Vassilis ; Zagouri, Flora ; Christoulas, Dimitrios ; Fontara, Sophia ; Panourgias, Evangelia ; Gavriatopoulou, Maria ; Kastritis, Efstathios ; Dimopoulos, Meletios A. ; Moulopoulos, Lia A.</creator><creatorcontrib>Terpos, Evangelos ; Matsaridis, Dimitris ; Koutoulidis, Vassilis ; Zagouri, Flora ; Christoulas, Dimitrios ; Fontara, Sophia ; Panourgias, Evangelia ; Gavriatopoulou, Maria ; Kastritis, Efstathios ; Dimopoulos, Meletios A. ; Moulopoulos, Lia A.</creatorcontrib><description>The aim of the study was to assess the value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in patients with newly diagnosed multiple myeloma (MM) who were treated with novel anti-myeloma agents. We studied 60 previously untreated MM patients at diagnosis, 14 with smoldering MM (SMM) and 5 with MGUS. All patients underwent MRI of the thoracolumbar spine and pelvis before the administration of any kind of therapy, and DCE-MRI was performed. The MRI perfusion parameters evaluated were wash-in (WIN), washout (WOUT), time-to-peak (TTPK), time-to-maximum slope (TMSP), and the WIN/TMSP ratio. The following serum levels of angiogenic cytokines were measured on the day of MRI: VEGF, angiogenin (Ang), angiopoietin-1 (Angp-1), and −2 (Angp-2). Symptomatic MM patients had increased WIN compared to SMM (
p
< 0.05) and MGUS patients (
p
= 0.001). TTPK was decreased, and WIN/TMSP was increased in both symptomatic and SMM patients compared to MGUS patients (
p
< 0.05). Symptomatic MM patients had decreased TMSP compared to MGUS patients. The Angp-1/Angp-2 ratio was reduced in symptomatic MM compared to SMM (
p
= 0.017) and MGUS patients (
p
< 0.001). TTPK correlated with Angp-1/Angp-2 ratio and importantly with R-ISS. Patients with R-ISS-3 had lower TTPK median value (23 s, range 18–29 s) compared to patients with R-ISS-2 (48 s, range 27–68 s) and patients with R-ISS-1 MM (54 s, range 42–76 s;
p
ANOVA = 0.01). A subset of patients with low TTPK (lower quartile) had shorter time to progression compared to all other patients. These data suggest that certain DCE-MRI parameters correlate with R-ISS and adverse prognostic features of angiogenesis, such as the ratio of Angp-1/Angp-2.</description><identifier>ISSN: 0939-5555</identifier><identifier>EISSN: 1432-0584</identifier><identifier>DOI: 10.1007/s00277-017-3078-7</identifier><identifier>PMID: 28766001</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aged ; Aged, 80 and over ; Angiopoietin-1 - blood ; Angiopoietin-2 - blood ; Female ; Hematology ; Humans ; Magnetic Resonance Imaging ; Male ; Medical prognosis ; Medicine ; Medicine & Public Health ; Middle Aged ; Multiple myeloma ; Multiple Myeloma - blood ; Multiple Myeloma - diagnosis ; Multiple Myeloma - diagnostic imaging ; Multiple Myeloma - therapy ; Neoplasm Proteins - blood ; NMR ; Nuclear magnetic resonance ; Oncology ; Original Article ; Pelvis - diagnostic imaging ; Spine - diagnostic imaging</subject><ispartof>Annals of hematology, 2017-10, Vol.96 (10), p.1707-1714</ispartof><rights>Springer-Verlag GmbH Germany 2017</rights><rights>Annals of Hematology is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-83ced2708b3a50fd8655e8963e6a5f428c25dc169c62ce23553734a52489003c3</citedby><cites>FETCH-LOGICAL-c372t-83ced2708b3a50fd8655e8963e6a5f428c25dc169c62ce23553734a52489003c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00277-017-3078-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00277-017-3078-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28766001$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Terpos, Evangelos</creatorcontrib><creatorcontrib>Matsaridis, Dimitris</creatorcontrib><creatorcontrib>Koutoulidis, Vassilis</creatorcontrib><creatorcontrib>Zagouri, Flora</creatorcontrib><creatorcontrib>Christoulas, Dimitrios</creatorcontrib><creatorcontrib>Fontara, Sophia</creatorcontrib><creatorcontrib>Panourgias, Evangelia</creatorcontrib><creatorcontrib>Gavriatopoulou, Maria</creatorcontrib><creatorcontrib>Kastritis, Efstathios</creatorcontrib><creatorcontrib>Dimopoulos, Meletios A.</creatorcontrib><creatorcontrib>Moulopoulos, Lia A.</creatorcontrib><title>Dynamic contrast-enhanced magnetic resonance imaging parameters correlate with advanced revised-ISS and angiopoietin-1/angiopoietin-2 ratio in patients with multiple myeloma</title><title>Annals of hematology</title><addtitle>Ann Hematol</addtitle><addtitle>Ann Hematol</addtitle><description>The aim of the study was to assess the value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in patients with newly diagnosed multiple myeloma (MM) who were treated with novel anti-myeloma agents. We studied 60 previously untreated MM patients at diagnosis, 14 with smoldering MM (SMM) and 5 with MGUS. All patients underwent MRI of the thoracolumbar spine and pelvis before the administration of any kind of therapy, and DCE-MRI was performed. The MRI perfusion parameters evaluated were wash-in (WIN), washout (WOUT), time-to-peak (TTPK), time-to-maximum slope (TMSP), and the WIN/TMSP ratio. The following serum levels of angiogenic cytokines were measured on the day of MRI: VEGF, angiogenin (Ang), angiopoietin-1 (Angp-1), and −2 (Angp-2). Symptomatic MM patients had increased WIN compared to SMM (
p
< 0.05) and MGUS patients (
p
= 0.001). TTPK was decreased, and WIN/TMSP was increased in both symptomatic and SMM patients compared to MGUS patients (
p
< 0.05). Symptomatic MM patients had decreased TMSP compared to MGUS patients. The Angp-1/Angp-2 ratio was reduced in symptomatic MM compared to SMM (
p
= 0.017) and MGUS patients (
p
< 0.001). TTPK correlated with Angp-1/Angp-2 ratio and importantly with R-ISS. Patients with R-ISS-3 had lower TTPK median value (23 s, range 18–29 s) compared to patients with R-ISS-2 (48 s, range 27–68 s) and patients with R-ISS-1 MM (54 s, range 42–76 s;
p
ANOVA = 0.01). A subset of patients with low TTPK (lower quartile) had shorter time to progression compared to all other patients. These data suggest that certain DCE-MRI parameters correlate with R-ISS and adverse prognostic features of angiogenesis, such as the ratio of Angp-1/Angp-2.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Angiopoietin-1 - blood</subject><subject>Angiopoietin-2 - blood</subject><subject>Female</subject><subject>Hematology</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Multiple myeloma</subject><subject>Multiple Myeloma - blood</subject><subject>Multiple Myeloma - diagnosis</subject><subject>Multiple Myeloma - diagnostic imaging</subject><subject>Multiple Myeloma - therapy</subject><subject>Neoplasm Proteins - blood</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Pelvis - diagnostic imaging</subject><subject>Spine - diagnostic imaging</subject><issn>0939-5555</issn><issn>1432-0584</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kV1rFTEQhoMo9tj6A7yRgDfexOZjs8leSv0qFHpRe72k2TmnKbvJmmRbzo_yPzqHraJCAyHMzDPvDHkJeSP4B8G5OS2cS2MYF4Ypbiwzz8hGNEoyrm3znGx4pzqm8RyRV6XccS6kbeRLciStaVsMN-Tnp310U_DUp1izK5VBvHXRw0Ant4tQsZShpHjI0YC5EHd0dtlNUCEX7MsZRleBPoR6S91wv3ZnuA8FBnZ-dUVdHPDuQppTQMXIxOk_oaTZ1ZBoiKhcA8RaVrVpGWuYR6DTHsY0uRPyYuvGAq8f32Ny_eXz97Nv7OLy6_nZxwvmlZGVWYUbSMPtjXKabwfbag22axW0Tm8bab3Ugxdt51vpQSqtlVGN07KxHefKq2PyftWdc_qxQKn9FIqHcXQR0lJ60UmthcAJiL77D71LS464HVIKAculREqslM-plAzbfs74mXnfC94fvOxXL3v0sj942RvsefuovNxMMPzp-G0eAnIFCpbiDvJfo59U_QVrFqxE</recordid><startdate>20171001</startdate><enddate>20171001</enddate><creator>Terpos, Evangelos</creator><creator>Matsaridis, Dimitris</creator><creator>Koutoulidis, Vassilis</creator><creator>Zagouri, Flora</creator><creator>Christoulas, Dimitrios</creator><creator>Fontara, Sophia</creator><creator>Panourgias, Evangelia</creator><creator>Gavriatopoulou, Maria</creator><creator>Kastritis, Efstathios</creator><creator>Dimopoulos, Meletios A.</creator><creator>Moulopoulos, Lia A.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20171001</creationdate><title>Dynamic contrast-enhanced magnetic resonance imaging parameters correlate with advanced revised-ISS and angiopoietin-1/angiopoietin-2 ratio in patients with multiple myeloma</title><author>Terpos, Evangelos ; Matsaridis, Dimitris ; Koutoulidis, Vassilis ; Zagouri, Flora ; Christoulas, Dimitrios ; Fontara, Sophia ; Panourgias, Evangelia ; Gavriatopoulou, Maria ; Kastritis, Efstathios ; Dimopoulos, Meletios A. ; Moulopoulos, Lia A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-83ced2708b3a50fd8655e8963e6a5f428c25dc169c62ce23553734a52489003c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Angiopoietin-1 - blood</topic><topic>Angiopoietin-2 - blood</topic><topic>Female</topic><topic>Hematology</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Multiple myeloma</topic><topic>Multiple Myeloma - blood</topic><topic>Multiple Myeloma - diagnosis</topic><topic>Multiple Myeloma - diagnostic imaging</topic><topic>Multiple Myeloma - therapy</topic><topic>Neoplasm Proteins - blood</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Pelvis - diagnostic imaging</topic><topic>Spine - diagnostic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Terpos, Evangelos</creatorcontrib><creatorcontrib>Matsaridis, Dimitris</creatorcontrib><creatorcontrib>Koutoulidis, Vassilis</creatorcontrib><creatorcontrib>Zagouri, Flora</creatorcontrib><creatorcontrib>Christoulas, Dimitrios</creatorcontrib><creatorcontrib>Fontara, Sophia</creatorcontrib><creatorcontrib>Panourgias, Evangelia</creatorcontrib><creatorcontrib>Gavriatopoulou, Maria</creatorcontrib><creatorcontrib>Kastritis, Efstathios</creatorcontrib><creatorcontrib>Dimopoulos, Meletios A.</creatorcontrib><creatorcontrib>Moulopoulos, Lia A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of hematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Terpos, Evangelos</au><au>Matsaridis, Dimitris</au><au>Koutoulidis, Vassilis</au><au>Zagouri, Flora</au><au>Christoulas, Dimitrios</au><au>Fontara, Sophia</au><au>Panourgias, Evangelia</au><au>Gavriatopoulou, Maria</au><au>Kastritis, Efstathios</au><au>Dimopoulos, Meletios A.</au><au>Moulopoulos, Lia A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dynamic contrast-enhanced magnetic resonance imaging parameters correlate with advanced revised-ISS and angiopoietin-1/angiopoietin-2 ratio in patients with multiple myeloma</atitle><jtitle>Annals of hematology</jtitle><stitle>Ann Hematol</stitle><addtitle>Ann Hematol</addtitle><date>2017-10-01</date><risdate>2017</risdate><volume>96</volume><issue>10</issue><spage>1707</spage><epage>1714</epage><pages>1707-1714</pages><issn>0939-5555</issn><eissn>1432-0584</eissn><abstract>The aim of the study was to assess the value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in patients with newly diagnosed multiple myeloma (MM) who were treated with novel anti-myeloma agents. We studied 60 previously untreated MM patients at diagnosis, 14 with smoldering MM (SMM) and 5 with MGUS. All patients underwent MRI of the thoracolumbar spine and pelvis before the administration of any kind of therapy, and DCE-MRI was performed. The MRI perfusion parameters evaluated were wash-in (WIN), washout (WOUT), time-to-peak (TTPK), time-to-maximum slope (TMSP), and the WIN/TMSP ratio. The following serum levels of angiogenic cytokines were measured on the day of MRI: VEGF, angiogenin (Ang), angiopoietin-1 (Angp-1), and −2 (Angp-2). Symptomatic MM patients had increased WIN compared to SMM (
p
< 0.05) and MGUS patients (
p
= 0.001). TTPK was decreased, and WIN/TMSP was increased in both symptomatic and SMM patients compared to MGUS patients (
p
< 0.05). Symptomatic MM patients had decreased TMSP compared to MGUS patients. The Angp-1/Angp-2 ratio was reduced in symptomatic MM compared to SMM (
p
= 0.017) and MGUS patients (
p
< 0.001). TTPK correlated with Angp-1/Angp-2 ratio and importantly with R-ISS. Patients with R-ISS-3 had lower TTPK median value (23 s, range 18–29 s) compared to patients with R-ISS-2 (48 s, range 27–68 s) and patients with R-ISS-1 MM (54 s, range 42–76 s;
p
ANOVA = 0.01). A subset of patients with low TTPK (lower quartile) had shorter time to progression compared to all other patients. These data suggest that certain DCE-MRI parameters correlate with R-ISS and adverse prognostic features of angiogenesis, such as the ratio of Angp-1/Angp-2.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>28766001</pmid><doi>10.1007/s00277-017-3078-7</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0939-5555 |
| ispartof | Annals of hematology, 2017-10, Vol.96 (10), p.1707-1714 |
| issn | 0939-5555 1432-0584 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1925511708 |
| source | MEDLINE; SpringerLink_现刊 |
| subjects | Aged Aged, 80 and over Angiopoietin-1 - blood Angiopoietin-2 - blood Female Hematology Humans Magnetic Resonance Imaging Male Medical prognosis Medicine Medicine & Public Health Middle Aged Multiple myeloma Multiple Myeloma - blood Multiple Myeloma - diagnosis Multiple Myeloma - diagnostic imaging Multiple Myeloma - therapy Neoplasm Proteins - blood NMR Nuclear magnetic resonance Oncology Original Article Pelvis - diagnostic imaging Spine - diagnostic imaging |
| title | Dynamic contrast-enhanced magnetic resonance imaging parameters correlate with advanced revised-ISS and angiopoietin-1/angiopoietin-2 ratio in patients with multiple myeloma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T15%3A27%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Dynamic%20contrast-enhanced%20magnetic%20resonance%20imaging%20parameters%20correlate%20with%20advanced%20revised-ISS%20and%20angiopoietin-1/angiopoietin-2%20ratio%20in%20patients%20with%20multiple%20myeloma&rft.jtitle=Annals%20of%20hematology&rft.au=Terpos,%20Evangelos&rft.date=2017-10-01&rft.volume=96&rft.issue=10&rft.spage=1707&rft.epage=1714&rft.pages=1707-1714&rft.issn=0939-5555&rft.eissn=1432-0584&rft_id=info:doi/10.1007/s00277-017-3078-7&rft_dat=%3Cproquest_cross%3E1925511708%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1930838022&rft_id=info:pmid/28766001&rfr_iscdi=true |