Control of the proliferation versus meiotic development decision in the C. elegans germline through regulation of GLD-1 protein accumulation
Maintenance of the stem cell population in the C. elegans germline requires GLP-1/Notch signaling. We show that this signaling inhibits the accumulation of the RNA binding protein GLD-1. In a genetic screen to identify other genes involved in regulating GLD-1 activity, we identified mutations in the...
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Veröffentlicht in: | Development (Cambridge) 2004-01, Vol.131 (1), p.93-104 |
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description | Maintenance of the stem cell population in the C. elegans germline requires GLP-1/Notch signaling. We show that this signaling inhibits the accumulation of the RNA binding protein GLD-1. In a genetic screen to identify other genes involved in regulating GLD-1 activity, we identified mutations in the nos-3 gene, the protein product of which is similar to the Drosophila translational regulator Nanos. Our data demonstrate that nos-3 promotes GLD-1 accumulation redundantly with gld-2 , and that nos-3 functions genetically downstream or parallel to fbf , an inhibitor of GLD-1 translation. We show that the GLD-1 accumulation pattern is important in controlling the proliferation versus meiotic development decision, with low GLD-1 levels allowing proliferation and increased levels promoting meiotic entry. |
doi_str_mv | 10.1242/dev.00916 |
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We show that this signaling inhibits the accumulation of the RNA binding protein GLD-1. In a genetic screen to identify other genes involved in regulating GLD-1 activity, we identified mutations in the nos-3 gene, the protein product of which is similar to the Drosophila translational regulator Nanos. Our data demonstrate that nos-3 promotes GLD-1 accumulation redundantly with gld-2 , and that nos-3 functions genetically downstream or parallel to fbf , an inhibitor of GLD-1 translation. 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We show that this signaling inhibits the accumulation of the RNA binding protein GLD-1. In a genetic screen to identify other genes involved in regulating GLD-1 activity, we identified mutations in the nos-3 gene, the protein product of which is similar to the Drosophila translational regulator Nanos. Our data demonstrate that nos-3 promotes GLD-1 accumulation redundantly with gld-2 , and that nos-3 functions genetically downstream or parallel to fbf , an inhibitor of GLD-1 translation. We show that the GLD-1 accumulation pattern is important in controlling the proliferation versus meiotic development decision, with low GLD-1 levels allowing proliferation and increased levels promoting meiotic entry.</description><subject>Animals</subject><subject>Caenorhabditis elegans</subject><subject>Caenorhabditis elegans - cytology</subject><subject>Caenorhabditis elegans - embryology</subject><subject>Caenorhabditis elegans - genetics</subject><subject>Caenorhabditis elegans Proteins - genetics</subject><subject>Cell Division</subject><subject>Embryo, Nonmammalian - cytology</subject><subject>Embryo, Nonmammalian - physiology</subject><subject>Gene Expression Regulation, Developmental - genetics</subject><subject>GLD-1 protein</subject><subject>In Situ Hybridization</subject><subject>Meiosis</subject><subject>Mutagenesis</subject><subject>Mutation</subject><subject>Nitric Oxide Synthase - genetics</subject><subject>Nitric Oxide Synthase Type III</subject><subject>nos-3 gene</subject><subject>Protein Biosynthesis</subject><subject>RNA, Helminth - genetics</subject><subject>Stem Cells - cytology</subject><subject>Stem Cells - physiology</subject><issn>0950-1991</issn><issn>1477-9129</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMFq3DAQhkVoSDabHPICRadCCd5ItmxZx-ImaWEhl70LWR57VWRrK8kpeYc8dLS7hp5mmPnm_4cfoXtKNjRn-WMHbxtCBK0u0IoyzjNBc_EFrYgoSUaFoNfoJoQ_hJCi4vwKXVNWVYQxskIfjZuidxa7Hsc94EPqTQ9eReMm_AY-zAGPYFw0GicfsO4wwhRTr004MmY6HTYbDBYGNQU8gB-tmSDNvZuHPfYwzPasmGxetj8zejSKkG6V1vO4bG_RZa9sgLulrtHu-WnX_Mq2ry-_mx_bTBesjplWRAGvu7Jue10p6KqatHVPKyZ6rTsBvG3TFDpGC91xYHmpiSqrgpeC5LxYo29n2fTD3xlClKMJGqxVE7g5SCrykpUn8PsZ1N6F4KGXB29G5d8lJfKYvEyJyFPyif26iM7tCN1_cok6AQ9nYG-G_T_jQbbGWTeYEINckpW0oJJKURSf6HySCQ</recordid><startdate>20040101</startdate><enddate>20040101</enddate><creator>Hansen, Dave</creator><creator>Wilson-Berry, Laura</creator><creator>Dang, Thanh</creator><creator>Schedl, Tim</creator><general>The Company of Biologists Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20040101</creationdate><title>Control of the proliferation versus meiotic development decision in the C. elegans germline through regulation of GLD-1 protein accumulation</title><author>Hansen, Dave ; 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source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection; Company of Biologists |
subjects | Animals Caenorhabditis elegans Caenorhabditis elegans - cytology Caenorhabditis elegans - embryology Caenorhabditis elegans - genetics Caenorhabditis elegans Proteins - genetics Cell Division Embryo, Nonmammalian - cytology Embryo, Nonmammalian - physiology Gene Expression Regulation, Developmental - genetics GLD-1 protein In Situ Hybridization Meiosis Mutagenesis Mutation Nitric Oxide Synthase - genetics Nitric Oxide Synthase Type III nos-3 gene Protein Biosynthesis RNA, Helminth - genetics Stem Cells - cytology Stem Cells - physiology |
title | Control of the proliferation versus meiotic development decision in the C. elegans germline through regulation of GLD-1 protein accumulation |
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