Neurotoxic character of thimerosal and the allometric extrapolation of adult clearance half-time to infants
The decomposition rate of organomercurials and the potency of the blood–brain barrier increase with the size of the organic radical. Thus methylmercury damages the brain more than thimerosal does, and when intake limits set for methylmercury are applied to thimerosal the safety margin is increased e...
Gespeichert in:
Veröffentlicht in: | Journal of applied toxicology 2003-07, Vol.23 (4), p.263-269 |
---|---|
1. Verfasser: | |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 269 |
---|---|
container_issue | 4 |
container_start_page | 263 |
container_title | Journal of applied toxicology |
container_volume | 23 |
creator | Magos, L. |
description | The decomposition rate of organomercurials and the potency of the blood–brain barrier increase with the size of the organic radical. Thus methylmercury damages the brain more than thimerosal does, and when intake limits set for methylmercury are applied to thimerosal the safety margin is increased even if the clearances were the same. However, the clearance half‐time of ethylmercury in adults is about one‐third of the 50 days' clearance half‐time of methylmercury given for 60 kg body weight. Moreover, because metabolic rates (e.g. basal metabolism, daily loss of mercury in per cent of body burden) in different weight groups are related to the fractional power of body weight (rule of allometry), mercury clears from the infant body faster than from the adult body. Blood mercury concentrations observed after vaccination showed agreement with allometrically extrapolated concentrations. Copyright © 2003 John Wiley & Sons, Ltd. |
doi_str_mv | 10.1002/jat.918 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_19253155</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>19253155</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4128-c72a2decb393d425523c4d92139ee273951c79f154a52e7dfae5f88ec0fedbde3</originalsourceid><addsrcrecordid>eNp10M1u1DAUBWALgei0IN4AZQMsUIp_4nG8bCsooKoUVKA7645zo3HrxIPtqNO3x6OM6IqVZfnTub6HkFeMHjNK-YdbyMeatU_IglGta8aX4ilZUL6kdSPUzQE5TOmW0vLG2-fkgPG2bRpGF-TuEqcYctg6W9k1RLAZYxX6Kq_dgDEk8BWMXbliBd6HAXMsFLc5wiZ4yC6MOw7d5HNlPZaI0WK1Bt_XuURUOVRu7GHM6QV51oNP-HJ_HpGfnz5en32uL76dfzk7uahtUz5WW8WBd2hXQouu4VJyYZtOcyY0IldCS2aV7plsQHJUXQ8o-7ZFS3vsVh2KI_J2zt3E8GfClM3gkkXvYcQwJcM0l4JJWeC7GdqyaIrYm010A8QHw6jZ9WpKr6b0WuTrfeS0GrB7dPsiC3izB5Bs2X3XgkuPrtGKiqUu7v3s7p3Hh__NM19Pruex9axdyrj9pyHemaUSSprfl-fmx-n3Xzfq6sqcir9BN5-D</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>19253155</pqid></control><display><type>article</type><title>Neurotoxic character of thimerosal and the allometric extrapolation of adult clearance half-time to infants</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Magos, L.</creator><creatorcontrib>Magos, L.</creatorcontrib><description>The decomposition rate of organomercurials and the potency of the blood–brain barrier increase with the size of the organic radical. Thus methylmercury damages the brain more than thimerosal does, and when intake limits set for methylmercury are applied to thimerosal the safety margin is increased even if the clearances were the same. However, the clearance half‐time of ethylmercury in adults is about one‐third of the 50 days' clearance half‐time of methylmercury given for 60 kg body weight. Moreover, because metabolic rates (e.g. basal metabolism, daily loss of mercury in per cent of body burden) in different weight groups are related to the fractional power of body weight (rule of allometry), mercury clears from the infant body faster than from the adult body. Blood mercury concentrations observed after vaccination showed agreement with allometrically extrapolated concentrations. Copyright © 2003 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0260-437X</identifier><identifier>EISSN: 1099-1263</identifier><identifier>DOI: 10.1002/jat.918</identifier><identifier>PMID: 12884410</identifier><identifier>CODEN: JJATDK</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Adult ; allometric extrapolation ; Animals ; Anti-Infective Agents, Local - adverse effects ; Anti-Infective Agents, Local - pharmacokinetics ; Biological and medical sciences ; Blood-Brain Barrier - drug effects ; Blood-Brain Barrier - physiology ; Body Constitution ; Chemical and industrial products toxicology. Toxic occupational diseases ; Epidemiology. Vaccinations ; ethylmercury ; Ethylmercury Compounds - pharmacokinetics ; Female ; General aspects ; Humans ; Infant ; Infant, Newborn ; infants ; Infectious diseases ; kinetics ; Medical sciences ; Metals and various inorganic compounds ; methylmercury ; Methylmercury Compounds - pharmacokinetics ; Models, Biological ; Preservatives, Pharmaceutical - adverse effects ; Preservatives, Pharmaceutical - pharmacokinetics ; Rats ; Species Specificity ; thimerosal ; Thimerosal - adverse effects ; Thimerosal - pharmacokinetics ; toxicity ; Toxicology ; Vaccination ; Vaccines</subject><ispartof>Journal of applied toxicology, 2003-07, Vol.23 (4), p.263-269</ispartof><rights>Copyright © 2003 John Wiley & Sons, Ltd.</rights><rights>2003 INIST-CNRS</rights><rights>Copyright 2003 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4128-c72a2decb393d425523c4d92139ee273951c79f154a52e7dfae5f88ec0fedbde3</citedby><cites>FETCH-LOGICAL-c4128-c72a2decb393d425523c4d92139ee273951c79f154a52e7dfae5f88ec0fedbde3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjat.918$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjat.918$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14970369$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12884410$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Magos, L.</creatorcontrib><title>Neurotoxic character of thimerosal and the allometric extrapolation of adult clearance half-time to infants</title><title>Journal of applied toxicology</title><addtitle>J. Appl. Toxicol</addtitle><description>The decomposition rate of organomercurials and the potency of the blood–brain barrier increase with the size of the organic radical. Thus methylmercury damages the brain more than thimerosal does, and when intake limits set for methylmercury are applied to thimerosal the safety margin is increased even if the clearances were the same. However, the clearance half‐time of ethylmercury in adults is about one‐third of the 50 days' clearance half‐time of methylmercury given for 60 kg body weight. Moreover, because metabolic rates (e.g. basal metabolism, daily loss of mercury in per cent of body burden) in different weight groups are related to the fractional power of body weight (rule of allometry), mercury clears from the infant body faster than from the adult body. Blood mercury concentrations observed after vaccination showed agreement with allometrically extrapolated concentrations. Copyright © 2003 John Wiley & Sons, Ltd.</description><subject>Adult</subject><subject>allometric extrapolation</subject><subject>Animals</subject><subject>Anti-Infective Agents, Local - adverse effects</subject><subject>Anti-Infective Agents, Local - pharmacokinetics</subject><subject>Biological and medical sciences</subject><subject>Blood-Brain Barrier - drug effects</subject><subject>Blood-Brain Barrier - physiology</subject><subject>Body Constitution</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Epidemiology. Vaccinations</subject><subject>ethylmercury</subject><subject>Ethylmercury Compounds - pharmacokinetics</subject><subject>Female</subject><subject>General aspects</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>infants</subject><subject>Infectious diseases</subject><subject>kinetics</subject><subject>Medical sciences</subject><subject>Metals and various inorganic compounds</subject><subject>methylmercury</subject><subject>Methylmercury Compounds - pharmacokinetics</subject><subject>Models, Biological</subject><subject>Preservatives, Pharmaceutical - adverse effects</subject><subject>Preservatives, Pharmaceutical - pharmacokinetics</subject><subject>Rats</subject><subject>Species Specificity</subject><subject>thimerosal</subject><subject>Thimerosal - adverse effects</subject><subject>Thimerosal - pharmacokinetics</subject><subject>toxicity</subject><subject>Toxicology</subject><subject>Vaccination</subject><subject>Vaccines</subject><issn>0260-437X</issn><issn>1099-1263</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10M1u1DAUBWALgei0IN4AZQMsUIp_4nG8bCsooKoUVKA7645zo3HrxIPtqNO3x6OM6IqVZfnTub6HkFeMHjNK-YdbyMeatU_IglGta8aX4ilZUL6kdSPUzQE5TOmW0vLG2-fkgPG2bRpGF-TuEqcYctg6W9k1RLAZYxX6Kq_dgDEk8BWMXbliBd6HAXMsFLc5wiZ4yC6MOw7d5HNlPZaI0WK1Bt_XuURUOVRu7GHM6QV51oNP-HJ_HpGfnz5en32uL76dfzk7uahtUz5WW8WBd2hXQouu4VJyYZtOcyY0IldCS2aV7plsQHJUXQ8o-7ZFS3vsVh2KI_J2zt3E8GfClM3gkkXvYcQwJcM0l4JJWeC7GdqyaIrYm010A8QHw6jZ9WpKr6b0WuTrfeS0GrB7dPsiC3izB5Bs2X3XgkuPrtGKiqUu7v3s7p3Hh__NM19Pruex9axdyrj9pyHemaUSSprfl-fmx-n3Xzfq6sqcir9BN5-D</recordid><startdate>200307</startdate><enddate>200307</enddate><creator>Magos, L.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>200307</creationdate><title>Neurotoxic character of thimerosal and the allometric extrapolation of adult clearance half-time to infants</title><author>Magos, L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4128-c72a2decb393d425523c4d92139ee273951c79f154a52e7dfae5f88ec0fedbde3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>allometric extrapolation</topic><topic>Animals</topic><topic>Anti-Infective Agents, Local - adverse effects</topic><topic>Anti-Infective Agents, Local - pharmacokinetics</topic><topic>Biological and medical sciences</topic><topic>Blood-Brain Barrier - drug effects</topic><topic>Blood-Brain Barrier - physiology</topic><topic>Body Constitution</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Epidemiology. Vaccinations</topic><topic>ethylmercury</topic><topic>Ethylmercury Compounds - pharmacokinetics</topic><topic>Female</topic><topic>General aspects</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>infants</topic><topic>Infectious diseases</topic><topic>kinetics</topic><topic>Medical sciences</topic><topic>Metals and various inorganic compounds</topic><topic>methylmercury</topic><topic>Methylmercury Compounds - pharmacokinetics</topic><topic>Models, Biological</topic><topic>Preservatives, Pharmaceutical - adverse effects</topic><topic>Preservatives, Pharmaceutical - pharmacokinetics</topic><topic>Rats</topic><topic>Species Specificity</topic><topic>thimerosal</topic><topic>Thimerosal - adverse effects</topic><topic>Thimerosal - pharmacokinetics</topic><topic>toxicity</topic><topic>Toxicology</topic><topic>Vaccination</topic><topic>Vaccines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Magos, L.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Journal of applied toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Magos, L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neurotoxic character of thimerosal and the allometric extrapolation of adult clearance half-time to infants</atitle><jtitle>Journal of applied toxicology</jtitle><addtitle>J. Appl. Toxicol</addtitle><date>2003-07</date><risdate>2003</risdate><volume>23</volume><issue>4</issue><spage>263</spage><epage>269</epage><pages>263-269</pages><issn>0260-437X</issn><eissn>1099-1263</eissn><coden>JJATDK</coden><abstract>The decomposition rate of organomercurials and the potency of the blood–brain barrier increase with the size of the organic radical. Thus methylmercury damages the brain more than thimerosal does, and when intake limits set for methylmercury are applied to thimerosal the safety margin is increased even if the clearances were the same. However, the clearance half‐time of ethylmercury in adults is about one‐third of the 50 days' clearance half‐time of methylmercury given for 60 kg body weight. Moreover, because metabolic rates (e.g. basal metabolism, daily loss of mercury in per cent of body burden) in different weight groups are related to the fractional power of body weight (rule of allometry), mercury clears from the infant body faster than from the adult body. Blood mercury concentrations observed after vaccination showed agreement with allometrically extrapolated concentrations. Copyright © 2003 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>12884410</pmid><doi>10.1002/jat.918</doi><tpages>7</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0260-437X |
ispartof | Journal of applied toxicology, 2003-07, Vol.23 (4), p.263-269 |
issn | 0260-437X 1099-1263 |
language | eng |
recordid | cdi_proquest_miscellaneous_19253155 |
source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
subjects | Adult allometric extrapolation Animals Anti-Infective Agents, Local - adverse effects Anti-Infective Agents, Local - pharmacokinetics Biological and medical sciences Blood-Brain Barrier - drug effects Blood-Brain Barrier - physiology Body Constitution Chemical and industrial products toxicology. Toxic occupational diseases Epidemiology. Vaccinations ethylmercury Ethylmercury Compounds - pharmacokinetics Female General aspects Humans Infant Infant, Newborn infants Infectious diseases kinetics Medical sciences Metals and various inorganic compounds methylmercury Methylmercury Compounds - pharmacokinetics Models, Biological Preservatives, Pharmaceutical - adverse effects Preservatives, Pharmaceutical - pharmacokinetics Rats Species Specificity thimerosal Thimerosal - adverse effects Thimerosal - pharmacokinetics toxicity Toxicology Vaccination Vaccines |
title | Neurotoxic character of thimerosal and the allometric extrapolation of adult clearance half-time to infants |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T15%3A43%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Neurotoxic%20character%20of%20thimerosal%20and%20the%20allometric%20extrapolation%20of%20adult%20clearance%20half-time%20to%20infants&rft.jtitle=Journal%20of%20applied%20toxicology&rft.au=Magos,%20L.&rft.date=2003-07&rft.volume=23&rft.issue=4&rft.spage=263&rft.epage=269&rft.pages=263-269&rft.issn=0260-437X&rft.eissn=1099-1263&rft.coden=JJATDK&rft_id=info:doi/10.1002/jat.918&rft_dat=%3Cproquest_cross%3E19253155%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=19253155&rft_id=info:pmid/12884410&rfr_iscdi=true |