Neurotoxic character of thimerosal and the allometric extrapolation of adult clearance half-time to infants

The decomposition rate of organomercurials and the potency of the blood–brain barrier increase with the size of the organic radical. Thus methylmercury damages the brain more than thimerosal does, and when intake limits set for methylmercury are applied to thimerosal the safety margin is increased e...

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Veröffentlicht in:Journal of applied toxicology 2003-07, Vol.23 (4), p.263-269
1. Verfasser: Magos, L.
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description The decomposition rate of organomercurials and the potency of the blood–brain barrier increase with the size of the organic radical. Thus methylmercury damages the brain more than thimerosal does, and when intake limits set for methylmercury are applied to thimerosal the safety margin is increased even if the clearances were the same. However, the clearance half‐time of ethylmercury in adults is about one‐third of the 50 days' clearance half‐time of methylmercury given for 60 kg body weight. Moreover, because metabolic rates (e.g. basal metabolism, daily loss of mercury in per cent of body burden) in different weight groups are related to the fractional power of body weight (rule of allometry), mercury clears from the infant body faster than from the adult body. Blood mercury concentrations observed after vaccination showed agreement with allometrically extrapolated concentrations. Copyright © 2003 John Wiley & Sons, Ltd.
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Thus methylmercury damages the brain more than thimerosal does, and when intake limits set for methylmercury are applied to thimerosal the safety margin is increased even if the clearances were the same. However, the clearance half‐time of ethylmercury in adults is about one‐third of the 50 days' clearance half‐time of methylmercury given for 60 kg body weight. Moreover, because metabolic rates (e.g. basal metabolism, daily loss of mercury in per cent of body burden) in different weight groups are related to the fractional power of body weight (rule of allometry), mercury clears from the infant body faster than from the adult body. Blood mercury concentrations observed after vaccination showed agreement with allometrically extrapolated concentrations. 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Appl. Toxicol</addtitle><description>The decomposition rate of organomercurials and the potency of the blood–brain barrier increase with the size of the organic radical. Thus methylmercury damages the brain more than thimerosal does, and when intake limits set for methylmercury are applied to thimerosal the safety margin is increased even if the clearances were the same. However, the clearance half‐time of ethylmercury in adults is about one‐third of the 50 days' clearance half‐time of methylmercury given for 60 kg body weight. Moreover, because metabolic rates (e.g. basal metabolism, daily loss of mercury in per cent of body burden) in different weight groups are related to the fractional power of body weight (rule of allometry), mercury clears from the infant body faster than from the adult body. Blood mercury concentrations observed after vaccination showed agreement with allometrically extrapolated concentrations. Copyright © 2003 John Wiley &amp; Sons, Ltd.</description><subject>Adult</subject><subject>allometric extrapolation</subject><subject>Animals</subject><subject>Anti-Infective Agents, Local - adverse effects</subject><subject>Anti-Infective Agents, Local - pharmacokinetics</subject><subject>Biological and medical sciences</subject><subject>Blood-Brain Barrier - drug effects</subject><subject>Blood-Brain Barrier - physiology</subject><subject>Body Constitution</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Epidemiology. Vaccinations</subject><subject>ethylmercury</subject><subject>Ethylmercury Compounds - pharmacokinetics</subject><subject>Female</subject><subject>General aspects</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>infants</subject><subject>Infectious diseases</subject><subject>kinetics</subject><subject>Medical sciences</subject><subject>Metals and various inorganic compounds</subject><subject>methylmercury</subject><subject>Methylmercury Compounds - pharmacokinetics</subject><subject>Models, Biological</subject><subject>Preservatives, Pharmaceutical - adverse effects</subject><subject>Preservatives, Pharmaceutical - pharmacokinetics</subject><subject>Rats</subject><subject>Species Specificity</subject><subject>thimerosal</subject><subject>Thimerosal - adverse effects</subject><subject>Thimerosal - pharmacokinetics</subject><subject>toxicity</subject><subject>Toxicology</subject><subject>Vaccination</subject><subject>Vaccines</subject><issn>0260-437X</issn><issn>1099-1263</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10M1u1DAUBWALgei0IN4AZQMsUIp_4nG8bCsooKoUVKA7645zo3HrxIPtqNO3x6OM6IqVZfnTub6HkFeMHjNK-YdbyMeatU_IglGta8aX4ilZUL6kdSPUzQE5TOmW0vLG2-fkgPG2bRpGF-TuEqcYctg6W9k1RLAZYxX6Kq_dgDEk8BWMXbliBd6HAXMsFLc5wiZ4yC6MOw7d5HNlPZaI0WK1Bt_XuURUOVRu7GHM6QV51oNP-HJ_HpGfnz5en32uL76dfzk7uahtUz5WW8WBd2hXQouu4VJyYZtOcyY0IldCS2aV7plsQHJUXQ8o-7ZFS3vsVh2KI_J2zt3E8GfClM3gkkXvYcQwJcM0l4JJWeC7GdqyaIrYm010A8QHw6jZ9WpKr6b0WuTrfeS0GrB7dPsiC3izB5Bs2X3XgkuPrtGKiqUu7v3s7p3Hh__NM19Pruex9axdyrj9pyHemaUSSprfl-fmx-n3Xzfq6sqcir9BN5-D</recordid><startdate>200307</startdate><enddate>200307</enddate><creator>Magos, L.</creator><general>John Wiley &amp; Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>200307</creationdate><title>Neurotoxic character of thimerosal and the allometric extrapolation of adult clearance half-time to infants</title><author>Magos, L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4128-c72a2decb393d425523c4d92139ee273951c79f154a52e7dfae5f88ec0fedbde3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>allometric extrapolation</topic><topic>Animals</topic><topic>Anti-Infective Agents, Local - adverse effects</topic><topic>Anti-Infective Agents, Local - pharmacokinetics</topic><topic>Biological and medical sciences</topic><topic>Blood-Brain Barrier - drug effects</topic><topic>Blood-Brain Barrier - physiology</topic><topic>Body Constitution</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Epidemiology. Vaccinations</topic><topic>ethylmercury</topic><topic>Ethylmercury Compounds - pharmacokinetics</topic><topic>Female</topic><topic>General aspects</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>infants</topic><topic>Infectious diseases</topic><topic>kinetics</topic><topic>Medical sciences</topic><topic>Metals and various inorganic compounds</topic><topic>methylmercury</topic><topic>Methylmercury Compounds - pharmacokinetics</topic><topic>Models, Biological</topic><topic>Preservatives, Pharmaceutical - adverse effects</topic><topic>Preservatives, Pharmaceutical - pharmacokinetics</topic><topic>Rats</topic><topic>Species Specificity</topic><topic>thimerosal</topic><topic>Thimerosal - adverse effects</topic><topic>Thimerosal - pharmacokinetics</topic><topic>toxicity</topic><topic>Toxicology</topic><topic>Vaccination</topic><topic>Vaccines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Magos, L.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Journal of applied toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Magos, L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neurotoxic character of thimerosal and the allometric extrapolation of adult clearance half-time to infants</atitle><jtitle>Journal of applied toxicology</jtitle><addtitle>J. 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Moreover, because metabolic rates (e.g. basal metabolism, daily loss of mercury in per cent of body burden) in different weight groups are related to the fractional power of body weight (rule of allometry), mercury clears from the infant body faster than from the adult body. Blood mercury concentrations observed after vaccination showed agreement with allometrically extrapolated concentrations. Copyright © 2003 John Wiley &amp; Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley &amp; Sons, Ltd</pub><pmid>12884410</pmid><doi>10.1002/jat.918</doi><tpages>7</tpages></addata></record>
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source MEDLINE; Wiley Online Library Journals Frontfile Complete
subjects Adult
allometric extrapolation
Animals
Anti-Infective Agents, Local - adverse effects
Anti-Infective Agents, Local - pharmacokinetics
Biological and medical sciences
Blood-Brain Barrier - drug effects
Blood-Brain Barrier - physiology
Body Constitution
Chemical and industrial products toxicology. Toxic occupational diseases
Epidemiology. Vaccinations
ethylmercury
Ethylmercury Compounds - pharmacokinetics
Female
General aspects
Humans
Infant
Infant, Newborn
infants
Infectious diseases
kinetics
Medical sciences
Metals and various inorganic compounds
methylmercury
Methylmercury Compounds - pharmacokinetics
Models, Biological
Preservatives, Pharmaceutical - adverse effects
Preservatives, Pharmaceutical - pharmacokinetics
Rats
Species Specificity
thimerosal
Thimerosal - adverse effects
Thimerosal - pharmacokinetics
toxicity
Toxicology
Vaccination
Vaccines
title Neurotoxic character of thimerosal and the allometric extrapolation of adult clearance half-time to infants
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