D816 mutation of the KIT gene in core binding factor acute myeloid leukemia is associated with poorer prognosis than other KIT gene mutations

The clinical impact of KIT mutations in core binding factor acute myeloid leukemia (CBF-AML) is still unclear. In the present study, we analyzed the prognostic significance of each KIT mutation (D816, N822K, and other mutations) in Japanese patients with CBF-AML. We retrospectively analyzed 136 case...

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Veröffentlicht in:	Annals of hematology 2017-10, Vol.96 (10), p.1641-1652
Hauptverfasser:	Yui, Shunsuke, Kurosawa, Saiko, Yamaguchi, Hiroki, Kanamori, Heiwa, Ueki, Toshimitsu, Uoshima, Nobuhiko, Mizuno, Ishikazu, Shono, Katsuhiro, Usuki, Kensuke, Chiba, Shigeru, Nakamura, Yukinori, Yanada, Masamitsu, Kanda, Junya, Tajika, Kenji, Gomi, Seiji, Fukunaga, Keiko, Wakita, Satoshi, Ryotokuji, Takeshi, Fukuda, Takahiro, Inokuchi, Koiti
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Amino Acid Substitution Chromosomes, Human - genetics Disease-Free Survival Female Hematology Humans Leukemia Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - mortality Male Medical prognosis Medicine Medicine & Public Health Middle Aged Mutation Mutation, Missense Oncology Original Article Proto-Oncogene Proteins c-kit - genetics Survival Rate Translocation, Genetic
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