Neurological soft signs precede the onset of schizophrenia: a study of individuals with schizotypy, ultra-high-risk individuals, and first-onset schizophrenia
Neurological soft signs (NSS) are one of the biomarkers for schizophrenia spectrum disorders. However, a few studies have examined the prevalence of NSS across the schizophrenia spectrum. The present study adopted a quasi-longitudinal study design and examined the prevalence of NSS and their associa...
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| Veröffentlicht in: | European archives of psychiatry and clinical neuroscience 2018-02, Vol.268 (1), p.49-56 |
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| creator | Chan, Raymond C. K. Cui, Hui-ru Chu, Min-yi Zhang, Tian-hong Wang, Ya Wang, Yi Li, Zhi Lui, Simon S. Y. Wang, Ji-jun Cheung, Eric F. C. |
| description | Neurological soft signs (NSS) are one of the biomarkers for schizophrenia spectrum disorders. However, a few studies have examined the prevalence of NSS across the schizophrenia spectrum. The present study adopted a quasi-longitudinal study design and examined the prevalence of NSS and their associations with clinical and behavioural manifestations in participants in different stages of the illness. The abridged version of the Cambridge Neurological Inventory was administered to 39 patients with the first-episode schizophrenia, 39 individuals with ultra-high risk (UHR) for psychosis, 39 individuals with schizotypy, and 39 healthy controls. Patients with the first-episode schizophrenia had a higher prevalence of NSS in motor coordination than healthy controls as well as individuals with UHR and schizotypy. Individuals with UHR exhibited a higher prevalence of sensory integration items than individuals with schizotypy and healthy controls. Discriminant analysis classified the membership of the individuals correctly across the spectrum with an accuracy of up to 60.9%. In particular, NSS could discriminate individuals with UHR from healthy controls at up to 85.9% accuracy. These findings suggest that NSS are robust biomarkers to detect and discriminate individuals in different stages of the schizophrenia spectrum from healthy controls. |
| doi_str_mv | 10.1007/s00406-017-0828-4 |
| format | Article |
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K. ; Cui, Hui-ru ; Chu, Min-yi ; Zhang, Tian-hong ; Wang, Ya ; Wang, Yi ; Li, Zhi ; Lui, Simon S. Y. ; Wang, Ji-jun ; Cheung, Eric F. C.</creator><creatorcontrib>Chan, Raymond C. K. ; Cui, Hui-ru ; Chu, Min-yi ; Zhang, Tian-hong ; Wang, Ya ; Wang, Yi ; Li, Zhi ; Lui, Simon S. Y. ; Wang, Ji-jun ; Cheung, Eric F. C.</creatorcontrib><description>Neurological soft signs (NSS) are one of the biomarkers for schizophrenia spectrum disorders. However, a few studies have examined the prevalence of NSS across the schizophrenia spectrum. The present study adopted a quasi-longitudinal study design and examined the prevalence of NSS and their associations with clinical and behavioural manifestations in participants in different stages of the illness. The abridged version of the Cambridge Neurological Inventory was administered to 39 patients with the first-episode schizophrenia, 39 individuals with ultra-high risk (UHR) for psychosis, 39 individuals with schizotypy, and 39 healthy controls. Patients with the first-episode schizophrenia had a higher prevalence of NSS in motor coordination than healthy controls as well as individuals with UHR and schizotypy. Individuals with UHR exhibited a higher prevalence of sensory integration items than individuals with schizotypy and healthy controls. Discriminant analysis classified the membership of the individuals correctly across the spectrum with an accuracy of up to 60.9%. In particular, NSS could discriminate individuals with UHR from healthy controls at up to 85.9% accuracy. These findings suggest that NSS are robust biomarkers to detect and discriminate individuals in different stages of the schizophrenia spectrum from healthy controls.</description><identifier>ISSN: 0940-1334</identifier><identifier>EISSN: 1433-8491</identifier><identifier>DOI: 10.1007/s00406-017-0828-4</identifier><identifier>PMID: 28761988</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adolescent ; Biomarkers ; Discriminant analysis ; Female ; Humans ; Longitudinal Studies ; Male ; Medicine ; Medicine & Public Health ; Mental disorders ; Nervous System Diseases - diagnosis ; Nervous System Diseases - etiology ; Neurologic Examination ; Neuropsychological Tests ; Neurosciences ; Original Paper ; Psychiatric Status Rating Scales ; Psychiatry ; Psychosis ; Schizophrenia ; Schizophrenia - diagnosis ; Schizophrenia - physiopathology ; Schizophrenic Psychology ; Schizotypal Personality Disorder - diagnosis ; Schizotypal Personality Disorder - physiopathology ; Schizotypal Personality Disorder - psychology ; Sensory integration ; Statistics as Topic ; Young Adult</subject><ispartof>European archives of psychiatry and clinical neuroscience, 2018-02, Vol.268 (1), p.49-56</ispartof><rights>Springer-Verlag GmbH Germany 2017</rights><rights>European Archives of Psychiatry and Clinical Neuroscience is a copyright of Springer, (2017). 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K.</creatorcontrib><creatorcontrib>Cui, Hui-ru</creatorcontrib><creatorcontrib>Chu, Min-yi</creatorcontrib><creatorcontrib>Zhang, Tian-hong</creatorcontrib><creatorcontrib>Wang, Ya</creatorcontrib><creatorcontrib>Wang, Yi</creatorcontrib><creatorcontrib>Li, Zhi</creatorcontrib><creatorcontrib>Lui, Simon S. Y.</creatorcontrib><creatorcontrib>Wang, Ji-jun</creatorcontrib><creatorcontrib>Cheung, Eric F. C.</creatorcontrib><title>Neurological soft signs precede the onset of schizophrenia: a study of individuals with schizotypy, ultra-high-risk individuals, and first-onset schizophrenia</title><title>European archives of psychiatry and clinical neuroscience</title><addtitle>Eur Arch Psychiatry Clin Neurosci</addtitle><addtitle>Eur Arch Psychiatry Clin Neurosci</addtitle><description>Neurological soft signs (NSS) are one of the biomarkers for schizophrenia spectrum disorders. However, a few studies have examined the prevalence of NSS across the schizophrenia spectrum. 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K.</au><au>Cui, Hui-ru</au><au>Chu, Min-yi</au><au>Zhang, Tian-hong</au><au>Wang, Ya</au><au>Wang, Yi</au><au>Li, Zhi</au><au>Lui, Simon S. Y.</au><au>Wang, Ji-jun</au><au>Cheung, Eric F. C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neurological soft signs precede the onset of schizophrenia: a study of individuals with schizotypy, ultra-high-risk individuals, and first-onset schizophrenia</atitle><jtitle>European archives of psychiatry and clinical neuroscience</jtitle><stitle>Eur Arch Psychiatry Clin Neurosci</stitle><addtitle>Eur Arch Psychiatry Clin Neurosci</addtitle><date>2018-02-01</date><risdate>2018</risdate><volume>268</volume><issue>1</issue><spage>49</spage><epage>56</epage><pages>49-56</pages><issn>0940-1334</issn><eissn>1433-8491</eissn><abstract>Neurological soft signs (NSS) are one of the biomarkers for schizophrenia spectrum disorders. However, a few studies have examined the prevalence of NSS across the schizophrenia spectrum. The present study adopted a quasi-longitudinal study design and examined the prevalence of NSS and their associations with clinical and behavioural manifestations in participants in different stages of the illness. The abridged version of the Cambridge Neurological Inventory was administered to 39 patients with the first-episode schizophrenia, 39 individuals with ultra-high risk (UHR) for psychosis, 39 individuals with schizotypy, and 39 healthy controls. Patients with the first-episode schizophrenia had a higher prevalence of NSS in motor coordination than healthy controls as well as individuals with UHR and schizotypy. Individuals with UHR exhibited a higher prevalence of sensory integration items than individuals with schizotypy and healthy controls. Discriminant analysis classified the membership of the individuals correctly across the spectrum with an accuracy of up to 60.9%. In particular, NSS could discriminate individuals with UHR from healthy controls at up to 85.9% accuracy. These findings suggest that NSS are robust biomarkers to detect and discriminate individuals in different stages of the schizophrenia spectrum from healthy controls.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>28761988</pmid><doi>10.1007/s00406-017-0828-4</doi><tpages>8</tpages></addata></record> |
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| subjects | Adolescent Biomarkers Discriminant analysis Female Humans Longitudinal Studies Male Medicine Medicine & Public Health Mental disorders Nervous System Diseases - diagnosis Nervous System Diseases - etiology Neurologic Examination Neuropsychological Tests Neurosciences Original Paper Psychiatric Status Rating Scales Psychiatry Psychosis Schizophrenia Schizophrenia - diagnosis Schizophrenia - physiopathology Schizophrenic Psychology Schizotypal Personality Disorder - diagnosis Schizotypal Personality Disorder - physiopathology Schizotypal Personality Disorder - psychology Sensory integration Statistics as Topic Young Adult |
| title | Neurological soft signs precede the onset of schizophrenia: a study of individuals with schizotypy, ultra-high-risk individuals, and first-onset schizophrenia |
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