PAR-1 and PAR-2 Expression Is Enhanced in Inflamed Odontoblast Cells

Protease-activated receptors (PARs) are G protein–coupled receptors, which are activated by proteolytical cleavage of the amino-terminus and act as sensors for extracellular proteases. We hypothesized that PAR-1 and PAR-2 can be modulated by inflammatory stimulus in human dental pulp cells. PAR-1 an...

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Veröffentlicht in:	Journal of dental research 2017-12, Vol.96 (13), p.1518-1525
Hauptverfasser:	Alvarez, M.M.P., Moura, G.E., Machado, M.F.M., Viana, G.M., de Souza Costa, C.A., Tjäderhane, L., Nader, H.B., Tersariol, I.L.S., Nascimento, F.D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Blotting, Western Bone marrow Chromatography, High Pressure Liquid Collagenase 3 Confocal microscopy Cytokines Dental caries Dental pulp Dental Pulp - cytology Dentin Dentistry Enzyme kinetics Flow Cytometry Gelatinase B Gene expression GLP-1 receptor agonists High-performance liquid chromatography Humans Immunofluorescence Inflammation Inflammation - metabolism Ligands Mass spectroscopy Matrix metalloproteinase Matrix Metalloproteinase 13 - metabolism Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - metabolism Metalloproteinase Microscopy, Confocal Monoclonal antibodies Odontoblasts Odontoblasts - enzymology Par-2 protein Peptides Polymerase chain reaction Protein expression Proteinase-activated receptor 1 Proteins Receptor, PAR-1 - metabolism Receptor, PAR-2 - metabolism RNA, Messenger - metabolism Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Teeth Trypsin Tubules Tumor necrosis factor-TNF Up-Regulation
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