Effect of intragastric FODMAP infusion on upper gastrointestinal motility, gastrointestinal, and psychological symptoms in irritable bowel syndrome vs healthy controls
Background The low fermentable oligo‐, di‐, mono‐saccharides and polyol (FODMAP) diet is a treatment strategy to reduce symptoms of irritable bowel syndrome (IBS). Acute effects of FODMAPs on upper gastrointestinal motility are incompletely understood. Our objectives were to assess the acute effects...
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| Veröffentlicht in: | Neurogastroenterology and motility 2018-01, Vol.30 (1), p.n/a |
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| creator | Masuy, I. Van Oudenhove, L. Tack, J. Biesiekierski, J. R. |
| description | Background
The low fermentable oligo‐, di‐, mono‐saccharides and polyol (FODMAP) diet is a treatment strategy to reduce symptoms of irritable bowel syndrome (IBS). Acute effects of FODMAPs on upper gastrointestinal motility are incompletely understood. Our objectives were to assess the acute effects of intragastric FODMAP infusions on upper gastrointestinal motility and gastrointestinal and psychological symptoms in healthy controls (HC) and IBS patients.
Methods
A high‐resolution solid‐state manometry probe and an infusion tube were positioned into the stomach. Fructans, fructose, FODMAP mix, or glucose was intragastrically administered to HC, and fructans or glucose was administered to IBS patients until full satiation (score 0‐5), in a randomized crossover fashion. Manometric measurements continued for 3 hours. Gastrointestinal and psychological symptoms were assessed by questionnaires at predefined time points. The study was registered on www.clinicaltrials.gov (NCT02980406).
Key Results
Twenty HC and 20 IBS patients were included. Fructans induced higher postprandial gastric pressures compared with glucose over both groups (P |
| doi_str_mv | 10.1111/nmo.13167 |
| format | Article |
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The low fermentable oligo‐, di‐, mono‐saccharides and polyol (FODMAP) diet is a treatment strategy to reduce symptoms of irritable bowel syndrome (IBS). Acute effects of FODMAPs on upper gastrointestinal motility are incompletely understood. Our objectives were to assess the acute effects of intragastric FODMAP infusions on upper gastrointestinal motility and gastrointestinal and psychological symptoms in healthy controls (HC) and IBS patients.
Methods
A high‐resolution solid‐state manometry probe and an infusion tube were positioned into the stomach. Fructans, fructose, FODMAP mix, or glucose was intragastrically administered to HC, and fructans or glucose was administered to IBS patients until full satiation (score 0‐5), in a randomized crossover fashion. Manometric measurements continued for 3 hours. Gastrointestinal and psychological symptoms were assessed by questionnaires at predefined time points. The study was registered on www.clinicaltrials.gov (NCT02980406).
Key Results
Twenty HC and 20 IBS patients were included. Fructans induced higher postprandial gastric pressures compared with glucose over both groups (P<.001). Bloating, belching, and pain increased more in IBS over both carbohydrates (P<.041). In addition, IBS patients reported more flatulence and cramps compared with HC following fructans (P<.001). Glucose induced more fatigue and dominance compared with fructans (P=.028, P=.001). Irritable bowel syndrome patients reported a higher increase in anger (P=.030) and a stronger decrease in positive affect (P=.021).
Conclusions & Inferences
The upper gastrointestinal motility response varies between carbohydrates. Irritable bowel syndrome patients are more sensitive to fructan infusion, reflected in their higher gastrointestinal symptom scores. Acute carbohydrate infusion can have differential psychological effects in IBS and HC.
The low fermentable oligo‐, di‐, mono‐saccharides and polyol (FODMAP) diet is a treatment strategy to reduce symptoms of irritable bowel syndrome. We assessed the acute effects of intragastric FODMAP infusions on upper gastrointestinal motility and gastrointestinal and psychological symptoms in 20 healthy controls (HC) and 20 IBS patients using high‐resolution solid‐state manometry and questionnaires. Fructans induced higher postprandial gastric pressures and higher gastrointestinal symptoms in IBS compared with HC. Fructans and glucose had differential psychological effects in IBS and HC.</description><identifier>ISSN: 1350-1925</identifier><identifier>EISSN: 1365-2982</identifier><identifier>DOI: 10.1111/nmo.13167</identifier><identifier>PMID: 28762592</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Acute effects ; Carbohydrates ; Fatigue ; FODMAPs ; Fructose ; Gastric motility ; Glucose ; Intestine ; Irritable bowel syndrome ; Motility ; Pain ; Satiety ; Stomach</subject><ispartof>Neurogastroenterology and motility, 2018-01, Vol.30 (1), p.n/a</ispartof><rights>2017 John Wiley & Sons Ltd</rights><rights>2017 John Wiley & Sons Ltd.</rights><rights>Copyright © 2018 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3537-c68eb8debd4ff6133d3cb7fa444c3669d9d84daedf19eb92ff5d0c1dbbbb111f3</citedby><cites>FETCH-LOGICAL-c3537-c68eb8debd4ff6133d3cb7fa444c3669d9d84daedf19eb92ff5d0c1dbbbb111f3</cites><orcidid>0000-0002-3206-6704</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fnmo.13167$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fnmo.13167$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28762592$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Masuy, I.</creatorcontrib><creatorcontrib>Van Oudenhove, L.</creatorcontrib><creatorcontrib>Tack, J.</creatorcontrib><creatorcontrib>Biesiekierski, J. R.</creatorcontrib><title>Effect of intragastric FODMAP infusion on upper gastrointestinal motility, gastrointestinal, and psychological symptoms in irritable bowel syndrome vs healthy controls</title><title>Neurogastroenterology and motility</title><addtitle>Neurogastroenterol Motil</addtitle><description>Background
The low fermentable oligo‐, di‐, mono‐saccharides and polyol (FODMAP) diet is a treatment strategy to reduce symptoms of irritable bowel syndrome (IBS). Acute effects of FODMAPs on upper gastrointestinal motility are incompletely understood. Our objectives were to assess the acute effects of intragastric FODMAP infusions on upper gastrointestinal motility and gastrointestinal and psychological symptoms in healthy controls (HC) and IBS patients.
Methods
A high‐resolution solid‐state manometry probe and an infusion tube were positioned into the stomach. Fructans, fructose, FODMAP mix, or glucose was intragastrically administered to HC, and fructans or glucose was administered to IBS patients until full satiation (score 0‐5), in a randomized crossover fashion. Manometric measurements continued for 3 hours. Gastrointestinal and psychological symptoms were assessed by questionnaires at predefined time points. The study was registered on www.clinicaltrials.gov (NCT02980406).
Key Results
Twenty HC and 20 IBS patients were included. Fructans induced higher postprandial gastric pressures compared with glucose over both groups (P<.001). Bloating, belching, and pain increased more in IBS over both carbohydrates (P<.041). In addition, IBS patients reported more flatulence and cramps compared with HC following fructans (P<.001). Glucose induced more fatigue and dominance compared with fructans (P=.028, P=.001). Irritable bowel syndrome patients reported a higher increase in anger (P=.030) and a stronger decrease in positive affect (P=.021).
Conclusions & Inferences
The upper gastrointestinal motility response varies between carbohydrates. Irritable bowel syndrome patients are more sensitive to fructan infusion, reflected in their higher gastrointestinal symptom scores. Acute carbohydrate infusion can have differential psychological effects in IBS and HC.
The low fermentable oligo‐, di‐, mono‐saccharides and polyol (FODMAP) diet is a treatment strategy to reduce symptoms of irritable bowel syndrome. We assessed the acute effects of intragastric FODMAP infusions on upper gastrointestinal motility and gastrointestinal and psychological symptoms in 20 healthy controls (HC) and 20 IBS patients using high‐resolution solid‐state manometry and questionnaires. Fructans induced higher postprandial gastric pressures and higher gastrointestinal symptoms in IBS compared with HC. Fructans and glucose had differential psychological effects in IBS and HC.</description><subject>Acute effects</subject><subject>Carbohydrates</subject><subject>Fatigue</subject><subject>FODMAPs</subject><subject>Fructose</subject><subject>Gastric motility</subject><subject>Glucose</subject><subject>Intestine</subject><subject>Irritable bowel syndrome</subject><subject>Motility</subject><subject>Pain</subject><subject>Satiety</subject><subject>Stomach</subject><issn>1350-1925</issn><issn>1365-2982</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kc1O3TAQhS1EBRS64AUqS2yoRCC2EydZIn7aSsDtol1Hjj3mGjlxajugPFFfsw4XWFB1NNJYnk9HM3MQOiT5KUlxNvTulDDCqy20RxgvM9rUdHt5l3lGGlruoo8hPOR5zmnBd9AurStOy4buoT9XWoOM2GlshujFvQjRG4mvV5e35z_Sn56CcQNOOY0jePwMuMRCiGYQFvcuGmvifPJP6wSLQeExzHLtrLs3MtFh7sfo-pCUsfHeRNFZwJ17gqU3KO96wI8Br0HYuJ6xdGkqZ8MB-qCFDfDppe6jX9dXPy--ZTerr98vzm8yyUpWZZLX0NUKOlVozQljismu0qIoCsk4b1Sj6kIJUJo00DVU61LlkqguRbqkZvvoeKM7evd7Sou0vQkSrBUDuCm0yzVpVVSkSejRO_TBTT7tvVBVXZa8yGmivmwo6V0IHnQ7etMLP7ckbxf32uRe--xeYj-_KE5dD-qNfLUrAWcb4MlYmP-v1N7drjaSfwFlPqnL</recordid><startdate>201801</startdate><enddate>201801</enddate><creator>Masuy, I.</creator><creator>Van Oudenhove, L.</creator><creator>Tack, J.</creator><creator>Biesiekierski, J. R.</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3206-6704</orcidid></search><sort><creationdate>201801</creationdate><title>Effect of intragastric FODMAP infusion on upper gastrointestinal motility, gastrointestinal, and psychological symptoms in irritable bowel syndrome vs healthy controls</title><author>Masuy, I. ; Van Oudenhove, L. ; Tack, J. ; Biesiekierski, J. R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3537-c68eb8debd4ff6133d3cb7fa444c3669d9d84daedf19eb92ff5d0c1dbbbb111f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Acute effects</topic><topic>Carbohydrates</topic><topic>Fatigue</topic><topic>FODMAPs</topic><topic>Fructose</topic><topic>Gastric motility</topic><topic>Glucose</topic><topic>Intestine</topic><topic>Irritable bowel syndrome</topic><topic>Motility</topic><topic>Pain</topic><topic>Satiety</topic><topic>Stomach</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Masuy, I.</creatorcontrib><creatorcontrib>Van Oudenhove, L.</creatorcontrib><creatorcontrib>Tack, J.</creatorcontrib><creatorcontrib>Biesiekierski, J. R.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Neurogastroenterology and motility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Masuy, I.</au><au>Van Oudenhove, L.</au><au>Tack, J.</au><au>Biesiekierski, J. R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of intragastric FODMAP infusion on upper gastrointestinal motility, gastrointestinal, and psychological symptoms in irritable bowel syndrome vs healthy controls</atitle><jtitle>Neurogastroenterology and motility</jtitle><addtitle>Neurogastroenterol Motil</addtitle><date>2018-01</date><risdate>2018</risdate><volume>30</volume><issue>1</issue><epage>n/a</epage><issn>1350-1925</issn><eissn>1365-2982</eissn><abstract>Background
The low fermentable oligo‐, di‐, mono‐saccharides and polyol (FODMAP) diet is a treatment strategy to reduce symptoms of irritable bowel syndrome (IBS). Acute effects of FODMAPs on upper gastrointestinal motility are incompletely understood. Our objectives were to assess the acute effects of intragastric FODMAP infusions on upper gastrointestinal motility and gastrointestinal and psychological symptoms in healthy controls (HC) and IBS patients.
Methods
A high‐resolution solid‐state manometry probe and an infusion tube were positioned into the stomach. Fructans, fructose, FODMAP mix, or glucose was intragastrically administered to HC, and fructans or glucose was administered to IBS patients until full satiation (score 0‐5), in a randomized crossover fashion. Manometric measurements continued for 3 hours. Gastrointestinal and psychological symptoms were assessed by questionnaires at predefined time points. The study was registered on www.clinicaltrials.gov (NCT02980406).
Key Results
Twenty HC and 20 IBS patients were included. Fructans induced higher postprandial gastric pressures compared with glucose over both groups (P<.001). Bloating, belching, and pain increased more in IBS over both carbohydrates (P<.041). In addition, IBS patients reported more flatulence and cramps compared with HC following fructans (P<.001). Glucose induced more fatigue and dominance compared with fructans (P=.028, P=.001). Irritable bowel syndrome patients reported a higher increase in anger (P=.030) and a stronger decrease in positive affect (P=.021).
Conclusions & Inferences
The upper gastrointestinal motility response varies between carbohydrates. Irritable bowel syndrome patients are more sensitive to fructan infusion, reflected in their higher gastrointestinal symptom scores. Acute carbohydrate infusion can have differential psychological effects in IBS and HC.
The low fermentable oligo‐, di‐, mono‐saccharides and polyol (FODMAP) diet is a treatment strategy to reduce symptoms of irritable bowel syndrome. We assessed the acute effects of intragastric FODMAP infusions on upper gastrointestinal motility and gastrointestinal and psychological symptoms in 20 healthy controls (HC) and 20 IBS patients using high‐resolution solid‐state manometry and questionnaires. Fructans induced higher postprandial gastric pressures and higher gastrointestinal symptoms in IBS compared with HC. Fructans and glucose had differential psychological effects in IBS and HC.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28762592</pmid><doi>10.1111/nmo.13167</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-3206-6704</orcidid></addata></record> |
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| subjects | Acute effects Carbohydrates Fatigue FODMAPs Fructose Gastric motility Glucose Intestine Irritable bowel syndrome Motility Pain Satiety Stomach |
| title | Effect of intragastric FODMAP infusion on upper gastrointestinal motility, gastrointestinal, and psychological symptoms in irritable bowel syndrome vs healthy controls |
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