Rifaximin Stability: A Look at UV, IR, HPLC, and Turbidimetry Methods
The study of the stability of medicines is mandated by the International Conference on Harmonization and the World Health Organization. Rifaximin, an antimicrobial marketed in the form of tablets, has no record of stability studies. Thus, the objective of the present work was to investigate the beha...
Gespeichert in:
| Veröffentlicht in: | Journal of AOAC International 2018-03, Vol.101 (2), p.410-413 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 413 |
|---|---|
| container_issue | 2 |
| container_start_page | 410 |
| container_title | Journal of AOAC International |
| container_volume | 101 |
| creator | Kogawa, Ana Carolina Salgado, Hérida Regina Nunes |
| description | The study of the stability of medicines is mandated by the International Conference on Harmonization and the World Health Organization. Rifaximin, an antimicrobial marketed in the form of tablets, has no record of stability studies. Thus, the objective of the present work was to investigate the behavior and stability of rifaximin tablets for 6 months under simultaneous conditions of temperature and humidity by UV, IR, HPLC, and turbidimetry techniques. After 6 months of stability study, rifaximin tablets were shown to obey zero-order kinetics when analyzed by physicochemical methods and second-order kinetics when analyzed by a microbiological method. However, the UV method was not suitable for the evaluation of rifaximin. IR, HPLC, and turbidimetry methods can already be used to evaluate the stability of rifaximin tablets. It is important to analyze products with more than one type of method before releasing results mainly in the case of antimicrobial products in which the association of physicochemical and microbiological techniques must be a rule. Rifaximin tablets can be considered stable after 6 months under conditions of 40 ± 2°C and 75 ± 5% relative humidity. |
| doi_str_mv | 10.5740/jaoacint.17-0102 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1925272598</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A530964381</galeid><sourcerecordid>A530964381</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-2aa4aa9a979df0a2d4cb3b6113bcb30ccb90ffbc7338c88e10c79952b6ae9e673</originalsourceid><addsrcrecordid>eNptkctLxDAQh4Movu-eJODFw3bNq03jbVl8wYri6xomaarRttEmC-5_b5dVQZA5zDB83zDwQ-iAknEuBTl5hQDWd2lMZUYoYWtomyohMqkYWx9mUpCMM0m30E6Mr4QIWhC2ibZYKQvGGd9GZ3e-hk_f-g7fJzC-8Wlxiid4FsIbhoQfn0b46m6EL29n0xGGrsIP8974yrcu9Qt87dJLqOIe2qihiW7_u--ix_Ozh-llNru5uJpOZpkVUqSMAQgABUqqqibAKmENNwWl3AwDsdYoUtfGSs5LW5aOEiuVypkpwClXSL6Ljld33_vwMXcx6dZH65oGOhfmUVPFciZZrsoBPVqhz9A47bs6pB7sEteTnBNVCF7SgRr_Qw1Vudbb0LnaD_s_AlkJtg8x9q7W771voV9oSvQyE_2TiaZSLzMZlMPvp-emddWv8BMC_wJMlYYX</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1925272598</pqid></control><display><type>article</type><title>Rifaximin Stability: A Look at UV, IR, HPLC, and Turbidimetry Methods</title><source>MEDLINE</source><source>Oxford University Press Journals All Titles (1996-Current)</source><creator>Kogawa, Ana Carolina ; Salgado, Hérida Regina Nunes</creator><creatorcontrib>Kogawa, Ana Carolina ; Salgado, Hérida Regina Nunes</creatorcontrib><description>The study of the stability of medicines is mandated by the International Conference on Harmonization and the World Health Organization. Rifaximin, an antimicrobial marketed in the form of tablets, has no record of stability studies. Thus, the objective of the present work was to investigate the behavior and stability of rifaximin tablets for 6 months under simultaneous conditions of temperature and humidity by UV, IR, HPLC, and turbidimetry techniques. After 6 months of stability study, rifaximin tablets were shown to obey zero-order kinetics when analyzed by physicochemical methods and second-order kinetics when analyzed by a microbiological method. However, the UV method was not suitable for the evaluation of rifaximin. IR, HPLC, and turbidimetry methods can already be used to evaluate the stability of rifaximin tablets. It is important to analyze products with more than one type of method before releasing results mainly in the case of antimicrobial products in which the association of physicochemical and microbiological techniques must be a rule. Rifaximin tablets can be considered stable after 6 months under conditions of 40 ± 2°C and 75 ± 5% relative humidity.</description><identifier>ISSN: 1060-3271</identifier><identifier>EISSN: 1944-7922</identifier><identifier>DOI: 10.5740/jaoacint.17-0102</identifier><identifier>PMID: 28762323</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Analysis ; Anti-Bacterial Agents - chemistry ; Chemical properties ; Chromatography, High Pressure Liquid - methods ; Drug Stability ; High performance liquid chromatography ; Humidity ; Kinetics ; Methods ; Nephelometry and Turbidimetry - methods ; Rifamycins - chemistry ; Rifaximin ; Spectrophotometry ; Spectrophotometry, Infrared - methods ; Spectrophotometry, Ultraviolet - methods ; Tablets ; Temperature</subject><ispartof>Journal of AOAC International, 2018-03, Vol.101 (2), p.410-413</ispartof><rights>COPYRIGHT 2018 Oxford University Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-2aa4aa9a979df0a2d4cb3b6113bcb30ccb90ffbc7338c88e10c79952b6ae9e673</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28762323$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kogawa, Ana Carolina</creatorcontrib><creatorcontrib>Salgado, Hérida Regina Nunes</creatorcontrib><title>Rifaximin Stability: A Look at UV, IR, HPLC, and Turbidimetry Methods</title><title>Journal of AOAC International</title><addtitle>J AOAC Int</addtitle><description>The study of the stability of medicines is mandated by the International Conference on Harmonization and the World Health Organization. Rifaximin, an antimicrobial marketed in the form of tablets, has no record of stability studies. Thus, the objective of the present work was to investigate the behavior and stability of rifaximin tablets for 6 months under simultaneous conditions of temperature and humidity by UV, IR, HPLC, and turbidimetry techniques. After 6 months of stability study, rifaximin tablets were shown to obey zero-order kinetics when analyzed by physicochemical methods and second-order kinetics when analyzed by a microbiological method. However, the UV method was not suitable for the evaluation of rifaximin. IR, HPLC, and turbidimetry methods can already be used to evaluate the stability of rifaximin tablets. It is important to analyze products with more than one type of method before releasing results mainly in the case of antimicrobial products in which the association of physicochemical and microbiological techniques must be a rule. Rifaximin tablets can be considered stable after 6 months under conditions of 40 ± 2°C and 75 ± 5% relative humidity.</description><subject>Analysis</subject><subject>Anti-Bacterial Agents - chemistry</subject><subject>Chemical properties</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Drug Stability</subject><subject>High performance liquid chromatography</subject><subject>Humidity</subject><subject>Kinetics</subject><subject>Methods</subject><subject>Nephelometry and Turbidimetry - methods</subject><subject>Rifamycins - chemistry</subject><subject>Rifaximin</subject><subject>Spectrophotometry</subject><subject>Spectrophotometry, Infrared - methods</subject><subject>Spectrophotometry, Ultraviolet - methods</subject><subject>Tablets</subject><subject>Temperature</subject><issn>1060-3271</issn><issn>1944-7922</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkctLxDAQh4Movu-eJODFw3bNq03jbVl8wYri6xomaarRttEmC-5_b5dVQZA5zDB83zDwQ-iAknEuBTl5hQDWd2lMZUYoYWtomyohMqkYWx9mUpCMM0m30E6Mr4QIWhC2ibZYKQvGGd9GZ3e-hk_f-g7fJzC-8Wlxiid4FsIbhoQfn0b46m6EL29n0xGGrsIP8974yrcu9Qt87dJLqOIe2qihiW7_u--ix_Ozh-llNru5uJpOZpkVUqSMAQgABUqqqibAKmENNwWl3AwDsdYoUtfGSs5LW5aOEiuVypkpwClXSL6Ljld33_vwMXcx6dZH65oGOhfmUVPFciZZrsoBPVqhz9A47bs6pB7sEteTnBNVCF7SgRr_Qw1Vudbb0LnaD_s_AlkJtg8x9q7W771voV9oSvQyE_2TiaZSLzMZlMPvp-emddWv8BMC_wJMlYYX</recordid><startdate>20180301</startdate><enddate>20180301</enddate><creator>Kogawa, Ana Carolina</creator><creator>Salgado, Hérida Regina Nunes</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20180301</creationdate><title>Rifaximin Stability: A Look at UV, IR, HPLC, and Turbidimetry Methods</title><author>Kogawa, Ana Carolina ; Salgado, Hérida Regina Nunes</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-2aa4aa9a979df0a2d4cb3b6113bcb30ccb90ffbc7338c88e10c79952b6ae9e673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Analysis</topic><topic>Anti-Bacterial Agents - chemistry</topic><topic>Chemical properties</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>Drug Stability</topic><topic>High performance liquid chromatography</topic><topic>Humidity</topic><topic>Kinetics</topic><topic>Methods</topic><topic>Nephelometry and Turbidimetry - methods</topic><topic>Rifamycins - chemistry</topic><topic>Rifaximin</topic><topic>Spectrophotometry</topic><topic>Spectrophotometry, Infrared - methods</topic><topic>Spectrophotometry, Ultraviolet - methods</topic><topic>Tablets</topic><topic>Temperature</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kogawa, Ana Carolina</creatorcontrib><creatorcontrib>Salgado, Hérida Regina Nunes</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of AOAC International</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kogawa, Ana Carolina</au><au>Salgado, Hérida Regina Nunes</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rifaximin Stability: A Look at UV, IR, HPLC, and Turbidimetry Methods</atitle><jtitle>Journal of AOAC International</jtitle><addtitle>J AOAC Int</addtitle><date>2018-03-01</date><risdate>2018</risdate><volume>101</volume><issue>2</issue><spage>410</spage><epage>413</epage><pages>410-413</pages><issn>1060-3271</issn><eissn>1944-7922</eissn><abstract>The study of the stability of medicines is mandated by the International Conference on Harmonization and the World Health Organization. Rifaximin, an antimicrobial marketed in the form of tablets, has no record of stability studies. Thus, the objective of the present work was to investigate the behavior and stability of rifaximin tablets for 6 months under simultaneous conditions of temperature and humidity by UV, IR, HPLC, and turbidimetry techniques. After 6 months of stability study, rifaximin tablets were shown to obey zero-order kinetics when analyzed by physicochemical methods and second-order kinetics when analyzed by a microbiological method. However, the UV method was not suitable for the evaluation of rifaximin. IR, HPLC, and turbidimetry methods can already be used to evaluate the stability of rifaximin tablets. It is important to analyze products with more than one type of method before releasing results mainly in the case of antimicrobial products in which the association of physicochemical and microbiological techniques must be a rule. Rifaximin tablets can be considered stable after 6 months under conditions of 40 ± 2°C and 75 ± 5% relative humidity.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>28762323</pmid><doi>10.5740/jaoacint.17-0102</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1060-3271 |
| ispartof | Journal of AOAC International, 2018-03, Vol.101 (2), p.410-413 |
| issn | 1060-3271 1944-7922 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1925272598 |
| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Analysis Anti-Bacterial Agents - chemistry Chemical properties Chromatography, High Pressure Liquid - methods Drug Stability High performance liquid chromatography Humidity Kinetics Methods Nephelometry and Turbidimetry - methods Rifamycins - chemistry Rifaximin Spectrophotometry Spectrophotometry, Infrared - methods Spectrophotometry, Ultraviolet - methods Tablets Temperature |
| title | Rifaximin Stability: A Look at UV, IR, HPLC, and Turbidimetry Methods |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T00%3A18%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Rifaximin%20Stability:%20A%20Look%20at%20UV,%20IR,%20HPLC,%20and%20Turbidimetry%20Methods&rft.jtitle=Journal%20of%20AOAC%20International&rft.au=Kogawa,%20Ana%20Carolina&rft.date=2018-03-01&rft.volume=101&rft.issue=2&rft.spage=410&rft.epage=413&rft.pages=410-413&rft.issn=1060-3271&rft.eissn=1944-7922&rft_id=info:doi/10.5740/jaoacint.17-0102&rft_dat=%3Cgale_proqu%3EA530964381%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1925272598&rft_id=info:pmid/28762323&rft_galeid=A530964381&rfr_iscdi=true |