Genome-wide DNA methylation profiling of the regenerative MRL/MpJ mouse and two normal strains
We aimed to identify the pivotal differences in the DNA methylation profiles between the regeneration capable MRL/MpJ mouse and reference mouse strains. Global DNA methylation profiling was performed in ear pinnae, bone marrow, spleen, liver and heart from uninjured adult females of the MRL/MpJ and...
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| Veröffentlicht in: | Epigenomics 2017-08, Vol.9 (8), p.1105-1122 |
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| creator | Górnikiewicz, Bartosz Ronowicz, Anna Madanecki, Piotr Sachadyn, Pawe |
| description | We aimed to identify the pivotal differences in the DNA methylation profiles between the regeneration capable MRL/MpJ mouse and reference mouse strains.
Global DNA methylation profiling was performed in ear pinnae, bone marrow, spleen, liver and heart from uninjured adult females of the MRL/MpJ and C57BL/6J and BALB/c.
A number of differentially methylated regions (DMRs) distinguishing between the MRL/MpJ mouse and both references were identified. In the ear pinnae, the DMRs were enriched in genes associated with development, inflammation and apoptosis, and in binding sites of transcriptional modulator Smad1. Several DMRs overlapped previously mapped quantitative trait loci of regenerative capability. The results suggest potential epigenetic determinants of regenerative phenomenon. |
| doi_str_mv | 10.2217/epi-2017-0009 |
| format | Article |
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Global DNA methylation profiling was performed in ear pinnae, bone marrow, spleen, liver and heart from uninjured adult females of the MRL/MpJ and C57BL/6J and BALB/c.
A number of differentially methylated regions (DMRs) distinguishing between the MRL/MpJ mouse and both references were identified. In the ear pinnae, the DMRs were enriched in genes associated with development, inflammation and apoptosis, and in binding sites of transcriptional modulator Smad1. Several DMRs overlapped previously mapped quantitative trait loci of regenerative capability. The results suggest potential epigenetic determinants of regenerative phenomenon.</description><identifier>ISSN: 1750-1911</identifier><identifier>EISSN: 1750-192X</identifier><identifier>DOI: 10.2217/epi-2017-0009</identifier><identifier>PMID: 28758427</identifier><language>eng</language><publisher>England: Future Medicine Ltd</publisher><subject>Animals ; Apoptosis ; Binding sites ; Bone marrow ; Cell cycle ; Deoxyribonucleic acid ; DNA ; DNA fingerprinting ; DNA Methylation ; Ear ; Epigenesis, Genetic ; Epigenetics ; Female ; Fibroblasts ; Gene expression ; Genome ; Genome-Wide Association Study ; Genomes ; Laboratory animals ; Mammals ; MeDIP-chip ; Metabolism ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Inbred MRL lpr ; microarray ; MRL/MpJ ; Quantitative trait loci ; Quantitative Trait, Heritable ; Regeneration ; Regeneration - genetics ; Scars ; Spleen ; Transcription ; Wound healing</subject><ispartof>Epigenomics, 2017-08, Vol.9 (8), p.1105-1122</ispartof><rights>2017 Future Medicine Ltd</rights><rights>Copyright Future Medicine Ltd Aug 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-f87e9c44e228b0439e1368bfe9b218094b76364fba0ff182191e82f7e8632e883</citedby><cites>FETCH-LOGICAL-c371t-f87e9c44e228b0439e1368bfe9b218094b76364fba0ff182191e82f7e8632e883</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2291618341/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2291618341?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,21389,27924,27925,33530,33531,43659,64385,64387,64389,72469,74104</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28758427$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Górnikiewicz, Bartosz</creatorcontrib><creatorcontrib>Ronowicz, Anna</creatorcontrib><creatorcontrib>Madanecki, Piotr</creatorcontrib><creatorcontrib>Sachadyn, Pawe</creatorcontrib><title>Genome-wide DNA methylation profiling of the regenerative MRL/MpJ mouse and two normal strains</title><title>Epigenomics</title><addtitle>Epigenomics</addtitle><description>We aimed to identify the pivotal differences in the DNA methylation profiles between the regeneration capable MRL/MpJ mouse and reference mouse strains.
Global DNA methylation profiling was performed in ear pinnae, bone marrow, spleen, liver and heart from uninjured adult females of the MRL/MpJ and C57BL/6J and BALB/c.
A number of differentially methylated regions (DMRs) distinguishing between the MRL/MpJ mouse and both references were identified. In the ear pinnae, the DMRs were enriched in genes associated with development, inflammation and apoptosis, and in binding sites of transcriptional modulator Smad1. Several DMRs overlapped previously mapped quantitative trait loci of regenerative capability. The results suggest potential epigenetic determinants of regenerative phenomenon.</description><subject>Animals</subject><subject>Apoptosis</subject><subject>Binding sites</subject><subject>Bone marrow</subject><subject>Cell cycle</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA fingerprinting</subject><subject>DNA Methylation</subject><subject>Ear</subject><subject>Epigenesis, Genetic</subject><subject>Epigenetics</subject><subject>Female</subject><subject>Fibroblasts</subject><subject>Gene expression</subject><subject>Genome</subject><subject>Genome-Wide Association Study</subject><subject>Genomes</subject><subject>Laboratory animals</subject><subject>Mammals</subject><subject>MeDIP-chip</subject><subject>Metabolism</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Inbred MRL lpr</subject><subject>microarray</subject><subject>MRL/MpJ</subject><subject>Quantitative trait loci</subject><subject>Quantitative Trait, Heritable</subject><subject>Regeneration</subject><subject>Regeneration - genetics</subject><subject>Scars</subject><subject>Spleen</subject><subject>Transcription</subject><subject>Wound healing</subject><issn>1750-1911</issn><issn>1750-192X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kM9LwzAYhoMoTqZHrxLw4qWaH12THMfUqUwFUfBkaLsvM9ImM2mV_fdmTD0InpKQ53t5vwehQ0pOGaPiDJY2Y4SKjBCittAeFSOSUcWet3_vlA7QQYxviSCcSVXQXTRgUoxkzsQeepmC8y1kn3YO-PxujFvoXldN2Vnv8DJ4YxvrFtgb3L0CDrAAByH9fgC-fZid3S5vcOv7CLh0c9x9eux8aMsGxy6U1sV9tGPKJsLB9zlET5cXj5OrbHY_vZ6MZ1nNBe0yIwWoOs-BMVmRnCugvJCVAVUxKonKK1HwIjdVSYyhkqW1QDIjQBacgZR8iE42uanyew-x062NNTRN6SDV08lJrshopHhCj_-gb74PLrXTjClaUMlzmqhsQ9XBxxjA6GWwbRlWmhK9dq-Te712r9fuE3_0ndpXLcx_6R_TCVAbwPRdHyDWFlwNevNKE7a2Dv4J_wLWhJEm</recordid><startdate>20170801</startdate><enddate>20170801</enddate><creator>Górnikiewicz, Bartosz</creator><creator>Ronowicz, Anna</creator><creator>Madanecki, Piotr</creator><creator>Sachadyn, Pawe</creator><general>Future Medicine Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>EHMNL</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20170801</creationdate><title>Genome-wide DNA methylation profiling of the regenerative MRL/MpJ mouse and two normal strains</title><author>Górnikiewicz, Bartosz ; Ronowicz, Anna ; Madanecki, Piotr ; Sachadyn, Pawe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-f87e9c44e228b0439e1368bfe9b218094b76364fba0ff182191e82f7e8632e883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Apoptosis</topic><topic>Binding sites</topic><topic>Bone marrow</topic><topic>Cell cycle</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA fingerprinting</topic><topic>DNA Methylation</topic><topic>Ear</topic><topic>Epigenesis, Genetic</topic><topic>Epigenetics</topic><topic>Female</topic><topic>Fibroblasts</topic><topic>Gene expression</topic><topic>Genome</topic><topic>Genome-Wide Association Study</topic><topic>Genomes</topic><topic>Laboratory animals</topic><topic>Mammals</topic><topic>MeDIP-chip</topic><topic>Metabolism</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Inbred MRL lpr</topic><topic>microarray</topic><topic>MRL/MpJ</topic><topic>Quantitative trait loci</topic><topic>Quantitative Trait, Heritable</topic><topic>Regeneration</topic><topic>Regeneration - genetics</topic><topic>Scars</topic><topic>Spleen</topic><topic>Transcription</topic><topic>Wound healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Górnikiewicz, Bartosz</creatorcontrib><creatorcontrib>Ronowicz, Anna</creatorcontrib><creatorcontrib>Madanecki, Piotr</creatorcontrib><creatorcontrib>Sachadyn, Pawe</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>UK & Ireland Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Epigenomics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Górnikiewicz, Bartosz</au><au>Ronowicz, Anna</au><au>Madanecki, Piotr</au><au>Sachadyn, Pawe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genome-wide DNA methylation profiling of the regenerative MRL/MpJ mouse and two normal strains</atitle><jtitle>Epigenomics</jtitle><addtitle>Epigenomics</addtitle><date>2017-08-01</date><risdate>2017</risdate><volume>9</volume><issue>8</issue><spage>1105</spage><epage>1122</epage><pages>1105-1122</pages><issn>1750-1911</issn><eissn>1750-192X</eissn><abstract>We aimed to identify the pivotal differences in the DNA methylation profiles between the regeneration capable MRL/MpJ mouse and reference mouse strains.
Global DNA methylation profiling was performed in ear pinnae, bone marrow, spleen, liver and heart from uninjured adult females of the MRL/MpJ and C57BL/6J and BALB/c.
A number of differentially methylated regions (DMRs) distinguishing between the MRL/MpJ mouse and both references were identified. In the ear pinnae, the DMRs were enriched in genes associated with development, inflammation and apoptosis, and in binding sites of transcriptional modulator Smad1. Several DMRs overlapped previously mapped quantitative trait loci of regenerative capability. The results suggest potential epigenetic determinants of regenerative phenomenon.</abstract><cop>England</cop><pub>Future Medicine Ltd</pub><pmid>28758427</pmid><doi>10.2217/epi-2017-0009</doi><tpages>18</tpages></addata></record> |
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| source | MEDLINE; ProQuest Central (Alumni Edition); ProQuest Central UK/Ireland; PubMed Central |
| subjects | Animals Apoptosis Binding sites Bone marrow Cell cycle Deoxyribonucleic acid DNA DNA fingerprinting DNA Methylation Ear Epigenesis, Genetic Epigenetics Female Fibroblasts Gene expression Genome Genome-Wide Association Study Genomes Laboratory animals Mammals MeDIP-chip Metabolism Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred MRL lpr microarray MRL/MpJ Quantitative trait loci Quantitative Trait, Heritable Regeneration Regeneration - genetics Scars Spleen Transcription Wound healing |
| title | Genome-wide DNA methylation profiling of the regenerative MRL/MpJ mouse and two normal strains |
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