Effectivity of oral recombinant DNA vaccine against Streptococcus agalactiae in Nile tilapia
The effects of oral vaccination by two immune routes (gavage and mixed fodder administration) using a recombinant DNA vaccine SL7207-pVAX1-sip against Streptococcus agalactiae were assessed. SL7207-pVAX1-sip significantly enhanced various innate immune responses of tilapia, such as total serum prote...
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| Veröffentlicht in: | Developmental and comparative immunology 2017-12, Vol.77, p.77-87 |
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| container_title | Developmental and comparative immunology |
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| creator | Zhu, Ling Yang, Qian Huang, Lingyuan Wang, Kaiyu Wang, Xingli Chen, Defang Geng, Yi Huang, Xiaoli Ouyang, Ping Lai, Weimin |
| description | The effects of oral vaccination by two immune routes (gavage and mixed fodder administration) using a recombinant DNA vaccine SL7207-pVAX1-sip against Streptococcus agalactiae were assessed. SL7207-pVAX1-sip significantly enhanced various innate immune responses of tilapia, such as total serum protein, superoxide dismutase activity, lysozyme activity, complement C3 concentration in serum, serum antibacterial activity, and interleukin 1β and tumor necrosis factor-α. Vaccinated fish had higher relative percent survival values (57% and 63% for gavage group and mix fodder administration, respectively) at 10 weeks after S. agalactiae infection. When administered mixed fodder, the DNA vaccine SL7207-pVAX1-sip against S. agalactiae may produce more effective protection. These findings can promote the application and development of DNA vaccines in aquaculture.
•Two immune routes of recombinant DNA vaccine SL7207-pVAX1-sip were assessed.•Host innate immune responses to vaccine were compared.•The vaccine against S. agalactiae with fodder administration can produce more effective protection. |
| doi_str_mv | 10.1016/j.dci.2017.07.024 |
| format | Article |
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•Two immune routes of recombinant DNA vaccine SL7207-pVAX1-sip were assessed.•Host innate immune responses to vaccine were compared.•The vaccine against S. agalactiae with fodder administration can produce more effective protection.</description><identifier>ISSN: 0145-305X</identifier><identifier>EISSN: 1879-0089</identifier><identifier>DOI: 10.1016/j.dci.2017.07.024</identifier><identifier>PMID: 28757159</identifier><language>eng</language><publisher>United States: Elsevier Ltd</publisher><subject>Administration, Oral ; Animals ; Antibacterial activity ; Aquaculture ; Bacterial Vaccines - immunology ; Complement C3 - metabolism ; Complement component C3 ; Deoxyribonucleic acid ; DNA ; DNA vaccine ; DNA vaccines ; Drug Administration Routes ; Fish Diseases - immunology ; Fish Proteins - metabolism ; Fodder ; Immune response ; Immune system ; Immunity, Innate ; Immunization ; Innate immunity ; Interleukin-1beta - metabolism ; Interleukins ; Lysozyme ; Muramidase - metabolism ; Nile tilapia ; Recombinant DNA ; S. agalactiae ; Streptococcal Infections - immunology ; Streptococcus agalactiae ; Streptococcus agalactiae - immunology ; Superoxide dismutase ; Superoxide Dismutase - metabolism ; Tilapia ; Tilapia - immunology ; Tilapia - microbiology ; Tumor Necrosis Factor-alpha - metabolism ; Tumor necrosis factor-α ; Up-Regulation ; Vaccination ; Vaccines ; Vaccines, DNA</subject><ispartof>Developmental and comparative immunology, 2017-12, Vol.77, p.77-87</ispartof><rights>2017 Elsevier Ltd</rights><rights>Copyright © 2017 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier Science Ltd. Dec 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-10250d7a94ab9cd2a8788c3c8861b4c4e73a7e5eea8396faae9fca1ee73721593</citedby><cites>FETCH-LOGICAL-c381t-10250d7a94ab9cd2a8788c3c8861b4c4e73a7e5eea8396faae9fca1ee73721593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0145305X17302537$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28757159$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhu, Ling</creatorcontrib><creatorcontrib>Yang, Qian</creatorcontrib><creatorcontrib>Huang, Lingyuan</creatorcontrib><creatorcontrib>Wang, Kaiyu</creatorcontrib><creatorcontrib>Wang, Xingli</creatorcontrib><creatorcontrib>Chen, Defang</creatorcontrib><creatorcontrib>Geng, Yi</creatorcontrib><creatorcontrib>Huang, Xiaoli</creatorcontrib><creatorcontrib>Ouyang, Ping</creatorcontrib><creatorcontrib>Lai, Weimin</creatorcontrib><title>Effectivity of oral recombinant DNA vaccine against Streptococcus agalactiae in Nile tilapia</title><title>Developmental and comparative immunology</title><addtitle>Dev Comp Immunol</addtitle><description>The effects of oral vaccination by two immune routes (gavage and mixed fodder administration) using a recombinant DNA vaccine SL7207-pVAX1-sip against Streptococcus agalactiae were assessed. SL7207-pVAX1-sip significantly enhanced various innate immune responses of tilapia, such as total serum protein, superoxide dismutase activity, lysozyme activity, complement C3 concentration in serum, serum antibacterial activity, and interleukin 1β and tumor necrosis factor-α. Vaccinated fish had higher relative percent survival values (57% and 63% for gavage group and mix fodder administration, respectively) at 10 weeks after S. agalactiae infection. When administered mixed fodder, the DNA vaccine SL7207-pVAX1-sip against S. agalactiae may produce more effective protection. These findings can promote the application and development of DNA vaccines in aquaculture.
•Two immune routes of recombinant DNA vaccine SL7207-pVAX1-sip were assessed.•Host innate immune responses to vaccine were compared.•The vaccine against S. agalactiae with fodder administration can produce more effective protection.</description><subject>Administration, Oral</subject><subject>Animals</subject><subject>Antibacterial activity</subject><subject>Aquaculture</subject><subject>Bacterial Vaccines - immunology</subject><subject>Complement C3 - metabolism</subject><subject>Complement component C3</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA vaccine</subject><subject>DNA vaccines</subject><subject>Drug Administration Routes</subject><subject>Fish Diseases - immunology</subject><subject>Fish Proteins - metabolism</subject><subject>Fodder</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunity, Innate</subject><subject>Immunization</subject><subject>Innate immunity</subject><subject>Interleukin-1beta - metabolism</subject><subject>Interleukins</subject><subject>Lysozyme</subject><subject>Muramidase - metabolism</subject><subject>Nile tilapia</subject><subject>Recombinant DNA</subject><subject>S. agalactiae</subject><subject>Streptococcal Infections - immunology</subject><subject>Streptococcus agalactiae</subject><subject>Streptococcus agalactiae - immunology</subject><subject>Superoxide dismutase</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Tilapia</subject><subject>Tilapia - immunology</subject><subject>Tilapia - microbiology</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><subject>Tumor necrosis factor-α</subject><subject>Up-Regulation</subject><subject>Vaccination</subject><subject>Vaccines</subject><subject>Vaccines, DNA</subject><issn>0145-305X</issn><issn>1879-0089</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1rGzEQhkVpSZyPH9BLEfSSy7qSdteS6CnksxDSQxLooSDGs7NFZr1yJa0h_z4yTnPoIWJAMDzzMvMw9lmKuRRy8W0179DPlZB6Lkqp5gObSaNtJYSxH9lMyKatatH-OmRHKa1EeUaKA3aojG61bO2M_b7qe8Lstz4_89DzEGHgkTCsl36EMfPL-3O-BUQ_Eoc_4MeU-UOOtMkBA-KUdt0BSgQQ9yO_9wPx7AfYeDhhn3oYEp2-_sfs6frq8eK2uvt58-Pi_K7C2shcSaFa0WmwDSwtdgqMNgZrNGYhlw02pGvQ1BKBqe2iByDbI0gqfa3KFfUxO9vnbmL4O1HKbu0T0jDASGFKTlrVGFtAU9Cv_6GrMMWxbOdUWUOLxtpdoNxTGENKkXq3iX4N8dlJ4Xbq3coV9W6n3olSqikzX16Tp-WaureJf64L8H0PUFGx9RRdQk8jUueL8Oy64N-JfwFnX5P5</recordid><startdate>201712</startdate><enddate>201712</enddate><creator>Zhu, Ling</creator><creator>Yang, Qian</creator><creator>Huang, Lingyuan</creator><creator>Wang, Kaiyu</creator><creator>Wang, Xingli</creator><creator>Chen, Defang</creator><creator>Geng, Yi</creator><creator>Huang, Xiaoli</creator><creator>Ouyang, Ping</creator><creator>Lai, Weimin</creator><general>Elsevier Ltd</general><general>Elsevier Science Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>201712</creationdate><title>Effectivity of oral recombinant DNA vaccine against Streptococcus agalactiae in Nile tilapia</title><author>Zhu, Ling ; Yang, Qian ; Huang, Lingyuan ; Wang, Kaiyu ; Wang, Xingli ; Chen, Defang ; Geng, Yi ; Huang, Xiaoli ; Ouyang, Ping ; Lai, Weimin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-10250d7a94ab9cd2a8788c3c8861b4c4e73a7e5eea8396faae9fca1ee73721593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Administration, Oral</topic><topic>Animals</topic><topic>Antibacterial activity</topic><topic>Aquaculture</topic><topic>Bacterial Vaccines - immunology</topic><topic>Complement C3 - metabolism</topic><topic>Complement component C3</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA vaccine</topic><topic>DNA vaccines</topic><topic>Drug Administration Routes</topic><topic>Fish Diseases - immunology</topic><topic>Fish Proteins - metabolism</topic><topic>Fodder</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Immunity, Innate</topic><topic>Immunization</topic><topic>Innate immunity</topic><topic>Interleukin-1beta - metabolism</topic><topic>Interleukins</topic><topic>Lysozyme</topic><topic>Muramidase - metabolism</topic><topic>Nile tilapia</topic><topic>Recombinant DNA</topic><topic>S. agalactiae</topic><topic>Streptococcal Infections - immunology</topic><topic>Streptococcus agalactiae</topic><topic>Streptococcus agalactiae - immunology</topic><topic>Superoxide dismutase</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Tilapia</topic><topic>Tilapia - immunology</topic><topic>Tilapia - microbiology</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><topic>Tumor necrosis factor-α</topic><topic>Up-Regulation</topic><topic>Vaccination</topic><topic>Vaccines</topic><topic>Vaccines, DNA</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhu, Ling</creatorcontrib><creatorcontrib>Yang, Qian</creatorcontrib><creatorcontrib>Huang, Lingyuan</creatorcontrib><creatorcontrib>Wang, Kaiyu</creatorcontrib><creatorcontrib>Wang, Xingli</creatorcontrib><creatorcontrib>Chen, Defang</creatorcontrib><creatorcontrib>Geng, Yi</creatorcontrib><creatorcontrib>Huang, Xiaoli</creatorcontrib><creatorcontrib>Ouyang, Ping</creatorcontrib><creatorcontrib>Lai, Weimin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Developmental and comparative immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhu, Ling</au><au>Yang, Qian</au><au>Huang, Lingyuan</au><au>Wang, Kaiyu</au><au>Wang, Xingli</au><au>Chen, Defang</au><au>Geng, Yi</au><au>Huang, Xiaoli</au><au>Ouyang, Ping</au><au>Lai, Weimin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effectivity of oral recombinant DNA vaccine against Streptococcus agalactiae in Nile tilapia</atitle><jtitle>Developmental and comparative immunology</jtitle><addtitle>Dev Comp Immunol</addtitle><date>2017-12</date><risdate>2017</risdate><volume>77</volume><spage>77</spage><epage>87</epage><pages>77-87</pages><issn>0145-305X</issn><eissn>1879-0089</eissn><abstract>The effects of oral vaccination by two immune routes (gavage and mixed fodder administration) using a recombinant DNA vaccine SL7207-pVAX1-sip against Streptococcus agalactiae were assessed. SL7207-pVAX1-sip significantly enhanced various innate immune responses of tilapia, such as total serum protein, superoxide dismutase activity, lysozyme activity, complement C3 concentration in serum, serum antibacterial activity, and interleukin 1β and tumor necrosis factor-α. Vaccinated fish had higher relative percent survival values (57% and 63% for gavage group and mix fodder administration, respectively) at 10 weeks after S. agalactiae infection. When administered mixed fodder, the DNA vaccine SL7207-pVAX1-sip against S. agalactiae may produce more effective protection. These findings can promote the application and development of DNA vaccines in aquaculture.
•Two immune routes of recombinant DNA vaccine SL7207-pVAX1-sip were assessed.•Host innate immune responses to vaccine were compared.•The vaccine against S. agalactiae with fodder administration can produce more effective protection.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>28757159</pmid><doi>10.1016/j.dci.2017.07.024</doi><tpages>11</tpages></addata></record> |
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| subjects | Administration, Oral Animals Antibacterial activity Aquaculture Bacterial Vaccines - immunology Complement C3 - metabolism Complement component C3 Deoxyribonucleic acid DNA DNA vaccine DNA vaccines Drug Administration Routes Fish Diseases - immunology Fish Proteins - metabolism Fodder Immune response Immune system Immunity, Innate Immunization Innate immunity Interleukin-1beta - metabolism Interleukins Lysozyme Muramidase - metabolism Nile tilapia Recombinant DNA S. agalactiae Streptococcal Infections - immunology Streptococcus agalactiae Streptococcus agalactiae - immunology Superoxide dismutase Superoxide Dismutase - metabolism Tilapia Tilapia - immunology Tilapia - microbiology Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-α Up-Regulation Vaccination Vaccines Vaccines, DNA |
| title | Effectivity of oral recombinant DNA vaccine against Streptococcus agalactiae in Nile tilapia |
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