15-Lipoxygenase-1 re-expression in colorectal cancer alters endothelial cell features through enhanced expression of TSP-1 and ICAM-1

15-lipoxygenase-1 (15-LOX-1) oxygenates linoleic acid to 13(S)-hydroxyoctadecadienoic acid (HODE). The enzyme is widely suppressed in different cancers and its re-expression has tumor suppressive effects. 15-LOX-1 has been shown to inhibit neoangiogenesis in colorectal cancer (CRC); in the present s...

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Veröffentlicht in:	Cellular signalling 2017-11, Vol.39, p.44-54
Hauptverfasser:	Tunçer, Sinem, Keşküş, Ayşe Gökçe, Çolakoğlu, Melis, Çimen, Ismail, Yener, Caner, Konu, Özlen, Banerjee, Sreeparna
Format:	Artikel
Sprache:	eng
Schlagworte:	15-LOX-1 Angiogenesis Animals Arachidonate 15-Lipoxygenase - metabolism Arachidonate 15-Lipoxygenase - secretion Cell Line, Tumor Cell Movement Colorectal cancer Colorectal Neoplasms - blood supply Culture Media, Conditioned - pharmacology HCT116 Cells Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - metabolism Humans Hydroxyeicosatetraenoic Acids - metabolism Hypoxia-Inducible Factor 1, alpha Subunit - metabolism ICAM-1 Intercellular Adhesion Molecule-1 - genetics Intercellular Adhesion Molecule-1 - metabolism Mice Mice, Inbred C57BL Neovascularization, Pathologic - metabolism Proteome - genetics Proteome - metabolism Thrombospondin 1 - genetics Thrombospondin 1 - metabolism Thrombospondin-1 Vascular Endothelial Growth Factor A - metabolism Vascular Endothelial Growth Factor A - secretion
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