Salt Gradient Modulation of MicroRNA Translocation through a Biological Nanopore

In resistive pulse sensing of microRNA biomarkers, selectivity is achieved with polynucleotide-extended DNA probes, with the unzipping of a miRNA–DNA duplex in the nanopore recorded as a resistive current pulse. As the assay sensitivity is determined by the pulse frequency, we investigated the effec...

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Veröffentlicht in:	Analytical chemistry (Washington) 2017-09, Vol.89 (17), p.8822-8829
Hauptverfasser:	Ivica, Josip, Williamson, Philip T. F, de Planque, Maurits R. R
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical chemistry Biomarkers Chemistry Concentration gradient Deoxyribonucleic acid Destabilization DNA DNA probes Dwell time Lithium chloride miRNA Porins Porosity Potassium chloride Probes Ribonucleic acid RNA Salts Selectivity Silicon nitride Stability Translocation
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