Disease-modifying effect of atipamezole in a model of post-traumatic epilepsy

•Atipamezole, improved motor performance after traumatic brain injury (TBI).•Atipamezole reduced seizure susceptibility after TBI.•Atipamezole had no effect on spatial memory performance after TBI.•SR141716A had no-disease modifying effect on TBI outcome. Treatment of TBI remains a major unmet medic...

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Veröffentlicht in:	Epilepsy research 2017-10, Vol.136, p.18-34
Hauptverfasser:	Nissinen, Jari, Andrade, Pedro, Natunen, Teemu, Hiltunen, Mikko, Malm, Tarja, Kanninen, Katja, Soares, Joana I., Shatillo, Olena, Sallinen, Jukka, Ndode-Ekane, Xavier Ekolle, Pitkänen, Asla
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-2 Receptor Antagonists - pharmacology Animals Anticonvulsants - pharmacology Axons - drug effects Axons - physiology Beam walking Body Temperature - drug effects Brain - drug effects Brain - physiopathology Cannabinoid 1 receptor antagonist Composite neuroscore Drug Evaluation, Preclinical Epilepsy, Post-Traumatic - drug therapy Epilepsy, Post-Traumatic - physiopathology Epilepsy, Post-Traumatic - psychology Epileptogenesis Imidazoles - pharmacology Lateral fluid-percussion Male Memory Motor Activity - drug effects Neuronal Plasticity - drug effects Neuronal Plasticity - physiology Neuroprotective Agents - pharmacology Piperidines - pharmacology Proof of Concept Study Pyrazoles - pharmacology Random Allocation Rats, Sprague-Dawley Recovery of Function - drug effects Seizure susceptibility Seizures - drug therapy Seizures - physiopathology Somato-motor performance Spatial Memory - drug effects SR141716A α2-Adrenoceptor
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