Prognostic value of the G8 and modified-G8 screening tools for multidimensional health problems in older patients with cancer
The G8 screening tool has been developed to identify older cancer patients requiring a geriatric assessment for tailoring therapy. Little is known about its prognostic value, particularly by tumour site. An optimised version has been recently developed, but no prognostic information is available. We...
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| Veröffentlicht in: | European journal of cancer (1990) 2017-09, Vol.83, p.211-219 |
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| creator | Martinez-Tapia, Claudia Paillaud, Elena Liuu, Evelyne Tournigand, Christophe Ibrahim, Rima Fossey-Diaz, Virginie Culine, Stéphane Canoui-Poitrine, Florence Audureau, Etienne Caillet, P. Laurent, M. Paillaud, E. Tournigand, C. Lagrange, J.-L. Canouï-Poitrine, F. Bastuji-Garin, S. Audureau, E. Natella, P.A. Segaux, L. Reinald, N. Allain, M. Ibrahim, R. Raccah, S. |
| description | The G8 screening tool has been developed to identify older cancer patients requiring a geriatric assessment for tailoring therapy. Little is known about its prognostic value, particularly by tumour site. An optimised version has been recently developed, but no prognostic information is available. We compared the prognostic value of both instruments overall and by tumour site.
Data were from a prospective cohort of cancer patients ≥70 years old referred to 1 of 6 French geriatric oncology clinics between 2007 and 2014 (n = 1333). Endpoints were overall 1- and 3-year survival. Cox proportional-hazards models were built to assess the predictive value of abnormal G8 and modified-G8 scores, based on published cut-offs or by classes of increasing risk. Sensitivity analyses involved adjusting for age, gender, treatment, metastasis, and tumour site (digestive, breast, urinary tract, prostate, other solid cancers, and haematological malignancies) and stratifying by tumour site and metastatic status.
Abnormal scores were independently associated with overall 1-year survival: adjusted hazard ratio [aHR] = 4.3[G8]/4.9[modified-G8] and 3-year survival: aHR = 2.9/2.6; all p |
| doi_str_mv | 10.1016/j.ejca.2017.06.027 |
| format | Article |
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Data were from a prospective cohort of cancer patients ≥70 years old referred to 1 of 6 French geriatric oncology clinics between 2007 and 2014 (n = 1333). Endpoints were overall 1- and 3-year survival. Cox proportional-hazards models were built to assess the predictive value of abnormal G8 and modified-G8 scores, based on published cut-offs or by classes of increasing risk. Sensitivity analyses involved adjusting for age, gender, treatment, metastasis, and tumour site (digestive, breast, urinary tract, prostate, other solid cancers, and haematological malignancies) and stratifying by tumour site and metastatic status.
Abnormal scores were independently associated with overall 1-year survival: adjusted hazard ratio [aHR] = 4.3[G8]/4.9[modified-G8] and 3-year survival: aHR = 2.9/2.6; all p <0.0001. Associations persisted after stratifying by metastatic status and in most cancer sites (exceptions: colorectal (G8) and upper digestive cancer (both tools) [1-year analysis]; digestive cancers (both tools) [3-year analysis]). For both tools, classes of increasing risk showed a graded relationship with mortality (p < 0.0001).
Our results identified both abnormal G8 and modified-G8 scores as strong and consistent predictors of overall survival, regardless of metastatic status or tumour site. These findings strengthen the clinical utility of these instruments in the geriatric oncology setting.
•We compared the prognostic value of 2 screening tools in older patients with cancer.•They help to better identify older cancer patients requiring a geriatric assessment.•Both scores showed good prognosis value for overall 1- and 3-year survival.•The associations persisted after stratifying by metastatic status and cancer site.•This supports the clinical utility of both tools in the geriatric oncology setting.</description><identifier>ISSN: 0959-8049</identifier><identifier>EISSN: 1879-0852</identifier><identifier>DOI: 10.1016/j.ejca.2017.06.027</identifier><identifier>PMID: 28750273</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Aged ; Aged, 80 and over ; Blood cancer ; Cancer ; Female ; Geriatric Assessment - methods ; Hazard assessment ; Health and safety screening ; Health problems ; Health Status ; Hematology ; Humans ; Male ; Medical prognosis ; Medical screening ; Metastases ; Mortality ; Neoplasms - complications ; Neoplasms - mortality ; Older people ; Patients ; Predictive Value of Tests ; Prognosis ; Proportional Hazards Models ; Prospective Studies ; Prostate ; Screening ; Sensitivity analysis ; Survival ; Tumors ; Urinary tract</subject><ispartof>European journal of cancer (1990), 2017-09, Vol.83, p.211-219</ispartof><rights>2017 Elsevier Ltd</rights><rights>Copyright © 2017 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier Science Ltd. Sep 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-5da56721e6106469ba9617ee04bf7a1dfac1fe72c9a5d254de5b325a8d0c56743</citedby><cites>FETCH-LOGICAL-c384t-5da56721e6106469ba9617ee04bf7a1dfac1fe72c9a5d254de5b325a8d0c56743</cites><orcidid>0000-0002-1244-0527</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S095980491731078X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28750273$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Martinez-Tapia, Claudia</creatorcontrib><creatorcontrib>Paillaud, Elena</creatorcontrib><creatorcontrib>Liuu, Evelyne</creatorcontrib><creatorcontrib>Tournigand, Christophe</creatorcontrib><creatorcontrib>Ibrahim, Rima</creatorcontrib><creatorcontrib>Fossey-Diaz, Virginie</creatorcontrib><creatorcontrib>Culine, Stéphane</creatorcontrib><creatorcontrib>Canoui-Poitrine, Florence</creatorcontrib><creatorcontrib>Audureau, Etienne</creatorcontrib><creatorcontrib>Caillet, P.</creatorcontrib><creatorcontrib>Laurent, M.</creatorcontrib><creatorcontrib>Paillaud, E.</creatorcontrib><creatorcontrib>Tournigand, C.</creatorcontrib><creatorcontrib>Lagrange, J.-L.</creatorcontrib><creatorcontrib>Canouï-Poitrine, F.</creatorcontrib><creatorcontrib>Bastuji-Garin, S.</creatorcontrib><creatorcontrib>Audureau, E.</creatorcontrib><creatorcontrib>Natella, P.A.</creatorcontrib><creatorcontrib>Segaux, L.</creatorcontrib><creatorcontrib>Reinald, N.</creatorcontrib><creatorcontrib>Allain, M.</creatorcontrib><creatorcontrib>Ibrahim, R.</creatorcontrib><creatorcontrib>Raccah, S.</creatorcontrib><creatorcontrib>ELCAPA Study Group</creatorcontrib><title>Prognostic value of the G8 and modified-G8 screening tools for multidimensional health problems in older patients with cancer</title><title>European journal of cancer (1990)</title><addtitle>Eur J Cancer</addtitle><description>The G8 screening tool has been developed to identify older cancer patients requiring a geriatric assessment for tailoring therapy. Little is known about its prognostic value, particularly by tumour site. An optimised version has been recently developed, but no prognostic information is available. We compared the prognostic value of both instruments overall and by tumour site.
Data were from a prospective cohort of cancer patients ≥70 years old referred to 1 of 6 French geriatric oncology clinics between 2007 and 2014 (n = 1333). Endpoints were overall 1- and 3-year survival. Cox proportional-hazards models were built to assess the predictive value of abnormal G8 and modified-G8 scores, based on published cut-offs or by classes of increasing risk. Sensitivity analyses involved adjusting for age, gender, treatment, metastasis, and tumour site (digestive, breast, urinary tract, prostate, other solid cancers, and haematological malignancies) and stratifying by tumour site and metastatic status.
Abnormal scores were independently associated with overall 1-year survival: adjusted hazard ratio [aHR] = 4.3[G8]/4.9[modified-G8] and 3-year survival: aHR = 2.9/2.6; all p <0.0001. Associations persisted after stratifying by metastatic status and in most cancer sites (exceptions: colorectal (G8) and upper digestive cancer (both tools) [1-year analysis]; digestive cancers (both tools) [3-year analysis]). For both tools, classes of increasing risk showed a graded relationship with mortality (p < 0.0001).
Our results identified both abnormal G8 and modified-G8 scores as strong and consistent predictors of overall survival, regardless of metastatic status or tumour site. These findings strengthen the clinical utility of these instruments in the geriatric oncology setting.
•We compared the prognostic value of 2 screening tools in older patients with cancer.•They help to better identify older cancer patients requiring a geriatric assessment.•Both scores showed good prognosis value for overall 1- and 3-year survival.•The associations persisted after stratifying by metastatic status and cancer site.•This supports the clinical utility of both tools in the geriatric oncology setting.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Blood cancer</subject><subject>Cancer</subject><subject>Female</subject><subject>Geriatric Assessment - methods</subject><subject>Hazard assessment</subject><subject>Health and safety screening</subject><subject>Health problems</subject><subject>Health Status</subject><subject>Hematology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medical screening</subject><subject>Metastases</subject><subject>Mortality</subject><subject>Neoplasms - complications</subject><subject>Neoplasms - mortality</subject><subject>Older people</subject><subject>Patients</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Prospective Studies</subject><subject>Prostate</subject><subject>Screening</subject><subject>Sensitivity analysis</subject><subject>Survival</subject><subject>Tumors</subject><subject>Urinary tract</subject><issn>0959-8049</issn><issn>1879-0852</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9v1DAQxS0EotuFL8ABWeLCJcF2_CeRuKAKWqRKcICz5diTriMnXmynFQe-O15t4cCB02g0v3maeQ-hV5S0lFD5bm5htqZlhKqWyJYw9QTtaK-GhvSCPUU7Moih6QkfLtBlzjMhRPWcPEcXrFei4t0O_fqa4t0ac_EW35uwAY4TLgfA1z02q8NLdH7y4JraZ5sAVr_e4RJjyHiKCS9bKN75Bdbs42oCPoAJ5YCPKY4Bloz9imNwkPDRFA9ryfjB17k1q4X0Aj2bTMjw8rHu0fdPH79d3TS3X64_X324bWzX89IIZ4RUjIKkRHI5jGaQVAEQPk7KUDcZSydQzA5GOCa4AzF2TJjeEVsXebdHb8-69awfG-SiF58thGBWiFvWdGBcEs5UX9E3_6Bz3FL9LGtGuo4NknNRKXambIo5J5j0MfnFpJ-aEn0KR8_6FI4-haOJ1Ce39-j1o_Q2LuD-rvxJowLvzwBUL-49JJ1t9cyC8wls0S76_-n_BgPtoQM</recordid><startdate>201709</startdate><enddate>201709</enddate><creator>Martinez-Tapia, Claudia</creator><creator>Paillaud, Elena</creator><creator>Liuu, Evelyne</creator><creator>Tournigand, Christophe</creator><creator>Ibrahim, Rima</creator><creator>Fossey-Diaz, Virginie</creator><creator>Culine, Stéphane</creator><creator>Canoui-Poitrine, Florence</creator><creator>Audureau, Etienne</creator><creator>Caillet, P.</creator><creator>Laurent, M.</creator><creator>Paillaud, E.</creator><creator>Tournigand, C.</creator><creator>Lagrange, J.-L.</creator><creator>Canouï-Poitrine, F.</creator><creator>Bastuji-Garin, S.</creator><creator>Audureau, E.</creator><creator>Natella, P.A.</creator><creator>Segaux, L.</creator><creator>Reinald, N.</creator><creator>Allain, M.</creator><creator>Ibrahim, R.</creator><creator>Raccah, S.</creator><general>Elsevier Ltd</general><general>Elsevier Science Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1244-0527</orcidid></search><sort><creationdate>201709</creationdate><title>Prognostic value of the G8 and modified-G8 screening tools for multidimensional health problems in older patients with cancer</title><author>Martinez-Tapia, Claudia ; Paillaud, Elena ; Liuu, Evelyne ; Tournigand, Christophe ; Ibrahim, Rima ; Fossey-Diaz, Virginie ; Culine, Stéphane ; Canoui-Poitrine, Florence ; Audureau, Etienne ; Caillet, P. ; Laurent, M. ; Paillaud, E. ; Tournigand, C. ; Lagrange, J.-L. ; Canouï-Poitrine, F. ; Bastuji-Garin, S. ; Audureau, E. ; Natella, P.A. ; Segaux, L. ; Reinald, N. ; Allain, M. ; Ibrahim, R. ; Raccah, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-5da56721e6106469ba9617ee04bf7a1dfac1fe72c9a5d254de5b325a8d0c56743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Blood cancer</topic><topic>Cancer</topic><topic>Female</topic><topic>Geriatric Assessment - methods</topic><topic>Hazard assessment</topic><topic>Health and safety screening</topic><topic>Health problems</topic><topic>Health Status</topic><topic>Hematology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Medical screening</topic><topic>Metastases</topic><topic>Mortality</topic><topic>Neoplasms - complications</topic><topic>Neoplasms - mortality</topic><topic>Older people</topic><topic>Patients</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Prospective Studies</topic><topic>Prostate</topic><topic>Screening</topic><topic>Sensitivity analysis</topic><topic>Survival</topic><topic>Tumors</topic><topic>Urinary tract</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Martinez-Tapia, Claudia</creatorcontrib><creatorcontrib>Paillaud, Elena</creatorcontrib><creatorcontrib>Liuu, Evelyne</creatorcontrib><creatorcontrib>Tournigand, Christophe</creatorcontrib><creatorcontrib>Ibrahim, Rima</creatorcontrib><creatorcontrib>Fossey-Diaz, Virginie</creatorcontrib><creatorcontrib>Culine, Stéphane</creatorcontrib><creatorcontrib>Canoui-Poitrine, Florence</creatorcontrib><creatorcontrib>Audureau, Etienne</creatorcontrib><creatorcontrib>Caillet, P.</creatorcontrib><creatorcontrib>Laurent, M.</creatorcontrib><creatorcontrib>Paillaud, E.</creatorcontrib><creatorcontrib>Tournigand, C.</creatorcontrib><creatorcontrib>Lagrange, J.-L.</creatorcontrib><creatorcontrib>Canouï-Poitrine, F.</creatorcontrib><creatorcontrib>Bastuji-Garin, S.</creatorcontrib><creatorcontrib>Audureau, E.</creatorcontrib><creatorcontrib>Natella, P.A.</creatorcontrib><creatorcontrib>Segaux, L.</creatorcontrib><creatorcontrib>Reinald, N.</creatorcontrib><creatorcontrib>Allain, M.</creatorcontrib><creatorcontrib>Ibrahim, R.</creatorcontrib><creatorcontrib>Raccah, S.</creatorcontrib><creatorcontrib>ELCAPA Study Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of cancer (1990)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Martinez-Tapia, Claudia</au><au>Paillaud, Elena</au><au>Liuu, Evelyne</au><au>Tournigand, Christophe</au><au>Ibrahim, Rima</au><au>Fossey-Diaz, Virginie</au><au>Culine, Stéphane</au><au>Canoui-Poitrine, Florence</au><au>Audureau, Etienne</au><au>Caillet, P.</au><au>Laurent, M.</au><au>Paillaud, E.</au><au>Tournigand, C.</au><au>Lagrange, J.-L.</au><au>Canouï-Poitrine, F.</au><au>Bastuji-Garin, S.</au><au>Audureau, E.</au><au>Natella, P.A.</au><au>Segaux, L.</au><au>Reinald, N.</au><au>Allain, M.</au><au>Ibrahim, R.</au><au>Raccah, S.</au><aucorp>ELCAPA Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic value of the G8 and modified-G8 screening tools for multidimensional health problems in older patients with cancer</atitle><jtitle>European journal of cancer (1990)</jtitle><addtitle>Eur J Cancer</addtitle><date>2017-09</date><risdate>2017</risdate><volume>83</volume><spage>211</spage><epage>219</epage><pages>211-219</pages><issn>0959-8049</issn><eissn>1879-0852</eissn><abstract>The G8 screening tool has been developed to identify older cancer patients requiring a geriatric assessment for tailoring therapy. Little is known about its prognostic value, particularly by tumour site. An optimised version has been recently developed, but no prognostic information is available. We compared the prognostic value of both instruments overall and by tumour site.
Data were from a prospective cohort of cancer patients ≥70 years old referred to 1 of 6 French geriatric oncology clinics between 2007 and 2014 (n = 1333). Endpoints were overall 1- and 3-year survival. Cox proportional-hazards models were built to assess the predictive value of abnormal G8 and modified-G8 scores, based on published cut-offs or by classes of increasing risk. Sensitivity analyses involved adjusting for age, gender, treatment, metastasis, and tumour site (digestive, breast, urinary tract, prostate, other solid cancers, and haematological malignancies) and stratifying by tumour site and metastatic status.
Abnormal scores were independently associated with overall 1-year survival: adjusted hazard ratio [aHR] = 4.3[G8]/4.9[modified-G8] and 3-year survival: aHR = 2.9/2.6; all p <0.0001. Associations persisted after stratifying by metastatic status and in most cancer sites (exceptions: colorectal (G8) and upper digestive cancer (both tools) [1-year analysis]; digestive cancers (both tools) [3-year analysis]). For both tools, classes of increasing risk showed a graded relationship with mortality (p < 0.0001).
Our results identified both abnormal G8 and modified-G8 scores as strong and consistent predictors of overall survival, regardless of metastatic status or tumour site. These findings strengthen the clinical utility of these instruments in the geriatric oncology setting.
•We compared the prognostic value of 2 screening tools in older patients with cancer.•They help to better identify older cancer patients requiring a geriatric assessment.•Both scores showed good prognosis value for overall 1- and 3-year survival.•The associations persisted after stratifying by metastatic status and cancer site.•This supports the clinical utility of both tools in the geriatric oncology setting.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>28750273</pmid><doi>10.1016/j.ejca.2017.06.027</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-1244-0527</orcidid></addata></record> |
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| ispartof | European journal of cancer (1990), 2017-09, Vol.83, p.211-219 |
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| subjects | Aged Aged, 80 and over Blood cancer Cancer Female Geriatric Assessment - methods Hazard assessment Health and safety screening Health problems Health Status Hematology Humans Male Medical prognosis Medical screening Metastases Mortality Neoplasms - complications Neoplasms - mortality Older people Patients Predictive Value of Tests Prognosis Proportional Hazards Models Prospective Studies Prostate Screening Sensitivity analysis Survival Tumors Urinary tract |
| title | Prognostic value of the G8 and modified-G8 screening tools for multidimensional health problems in older patients with cancer |
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