Injectable hydrogel based on quaternized chitosan, gelatin and dopamine as localized drug delivery system to treat Parkinson’s disease

•Faclie sythesis of injectable hydrogels from quaternized chitosan, gelatin and dopamine.•These hydrogels can in situ encapsulate anti-inflammatory drug and free dopamine.•These hydrogels showed great promise as long term localized drug delivery systems.•Excellent cytocompatibility of the hydrogels...

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Veröffentlicht in:	International journal of biological macromolecules 2017-12, Vol.105 (Pt 1), p.1079-1087
Hauptverfasser:	Ren, Yizhuo, Zhao, Xin, Liang, Xiaofeng, Ma, Peter X., Guo, Baolin
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line Chitosan - chemistry Dopamine - chemistry Dopamine - therapeutic use Drug Carriers - chemistry Drug Carriers - pharmacology Drug Liberation Drug release Gelatin Gelatin - chemistry Hydrogels - chemistry Injectable hydrogel Injections Materials Testing Parkinson Disease - drug therapy Parkinson’s disease Polydopamine Porosity Quaternized chitosan
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