Analysis of the expression of HAX-1 gene in human glioma
Glioma, as the most common aggressive malignant tumor in the central nervous system, is still an insurmountable issue in neural diseases. The proliferation and survival mechanism of glioma cells need to be explored further for the development of glioma treatment. Hematopoietic cell-specific protein...
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| Veröffentlicht in: | Neuroscience letters 2017-09, Vol.657, p.189-193 |
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| creator | Deng, Xin Song, Laijun Wei, Ying Guo, Xin-bin |
| description | Glioma, as the most common aggressive malignant tumor in the central nervous system, is still an insurmountable issue in neural diseases. The proliferation and survival mechanism of glioma cells need to be explored further for the development of glioma treatment. Hematopoietic cell-specific protein 1 associated protein X-1 (HAX-1) is well known for its anti-apoptotic effect. It was reported to play an important role in several malignant tumors. However, the effect of HAX-1 in glioma still remains unknown. This study aimed to investigate the expression of HAX-1 in glioma and the correlation between HAX-1 and the clinicopathological characteristics and prognosis of glioma. Quantitative reverse transcription polymerase chain reaction and Western blot analysis showed that HAX-1 was overexpressed in glioma cell lines compared with normal human astrocytes. This trend was confirmed by comparing the expression of HAX-1 in glioma tissues and nontumorous tissues. The study also analyzed the correlation between the expression of HAX-1 and clinicopathological characteristics of glioma and found the expression of HAX-1 to be highly related to the differentiation and World Health Organization stage of glioma tissues. The survival analysis revealed that HAX-1 was an independent prognostic factor. In conclusion, this novel study suggested that the overexpression of HAX-1 might contribute to the malignant progression of glioma. |
| doi_str_mv | 10.1016/j.neulet.2017.07.039 |
| format | Article |
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The proliferation and survival mechanism of glioma cells need to be explored further for the development of glioma treatment. Hematopoietic cell-specific protein 1 associated protein X-1 (HAX-1) is well known for its anti-apoptotic effect. It was reported to play an important role in several malignant tumors. However, the effect of HAX-1 in glioma still remains unknown. This study aimed to investigate the expression of HAX-1 in glioma and the correlation between HAX-1 and the clinicopathological characteristics and prognosis of glioma. Quantitative reverse transcription polymerase chain reaction and Western blot analysis showed that HAX-1 was overexpressed in glioma cell lines compared with normal human astrocytes. This trend was confirmed by comparing the expression of HAX-1 in glioma tissues and nontumorous tissues. The study also analyzed the correlation between the expression of HAX-1 and clinicopathological characteristics of glioma and found the expression of HAX-1 to be highly related to the differentiation and World Health Organization stage of glioma tissues. The survival analysis revealed that HAX-1 was an independent prognostic factor. In conclusion, this novel study suggested that the overexpression of HAX-1 might contribute to the malignant progression of glioma.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/j.neulet.2017.07.039</identifier><identifier>PMID: 28751207</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Adaptor Proteins, Signal Transducing - metabolism ; Aged ; Astrocytes ; Cell Line, Tumor ; Central Nervous System Neoplasms - metabolism ; Central Nervous System Neoplasms - pathology ; Disease Progression ; Female ; Glioma ; Glioma - metabolism ; Glioma - pathology ; HAX-1 ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Prognosis ; Quantitative PCR ; Survival Analysis</subject><ispartof>Neuroscience letters, 2017-09, Vol.657, p.189-193</ispartof><rights>2017 Elsevier B.V.</rights><rights>Copyright © 2017 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-54ed0dd071286870c1c9f896adba09dee1ae588a5b21a23b26ee6c204eb8a7843</citedby><cites>FETCH-LOGICAL-c362t-54ed0dd071286870c1c9f896adba09dee1ae588a5b21a23b26ee6c204eb8a7843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0304394017306110$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28751207$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Deng, Xin</creatorcontrib><creatorcontrib>Song, Laijun</creatorcontrib><creatorcontrib>Wei, Ying</creatorcontrib><creatorcontrib>Guo, Xin-bin</creatorcontrib><title>Analysis of the expression of HAX-1 gene in human glioma</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>Glioma, as the most common aggressive malignant tumor in the central nervous system, is still an insurmountable issue in neural diseases. The proliferation and survival mechanism of glioma cells need to be explored further for the development of glioma treatment. Hematopoietic cell-specific protein 1 associated protein X-1 (HAX-1) is well known for its anti-apoptotic effect. It was reported to play an important role in several malignant tumors. However, the effect of HAX-1 in glioma still remains unknown. This study aimed to investigate the expression of HAX-1 in glioma and the correlation between HAX-1 and the clinicopathological characteristics and prognosis of glioma. Quantitative reverse transcription polymerase chain reaction and Western blot analysis showed that HAX-1 was overexpressed in glioma cell lines compared with normal human astrocytes. This trend was confirmed by comparing the expression of HAX-1 in glioma tissues and nontumorous tissues. The study also analyzed the correlation between the expression of HAX-1 and clinicopathological characteristics of glioma and found the expression of HAX-1 to be highly related to the differentiation and World Health Organization stage of glioma tissues. The survival analysis revealed that HAX-1 was an independent prognostic factor. In conclusion, this novel study suggested that the overexpression of HAX-1 might contribute to the malignant progression of glioma.</description><subject>Adaptor Proteins, Signal Transducing - metabolism</subject><subject>Aged</subject><subject>Astrocytes</subject><subject>Cell Line, Tumor</subject><subject>Central Nervous System Neoplasms - metabolism</subject><subject>Central Nervous System Neoplasms - pathology</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Glioma</subject><subject>Glioma - metabolism</subject><subject>Glioma - pathology</subject><subject>HAX-1</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prognosis</subject><subject>Quantitative PCR</subject><subject>Survival Analysis</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1LxDAQxYMo7rr6H4j06KV1kn4kuQiLqCsseFHwFtJ0upulH2vSivvf29LVo_BgYPi9ecwj5JpCRIFmd7uowb7CLmJAeQSDYnlC5lRwFnLJ2SmZQwxJGMsEZuTC-x0ApDRNzsmMCZ5SBnxOxLLR1cFbH7Rl0G0xwO-9Q-9t24yb1fIjpMEGGwxsE2z7WjfBprJtrS_JWakrj1fHuSDvT49vD6tw_fr88rBchybOWBemCRZQFMApE5ngYKiRpZCZLnINskCkGlMhdJozqlmcswwxMwwSzIXmIokX5Ha6u3ftZ4--U7X1BqtKN9j2XlHJklTKWMgBTSbUuNZ7h6XaO1trd1AU1NiZ2qmpMzV2pmBQPNpujgl9XmPxZ_otaQDuJwCHP78sOuWNxcZgYR2aThWt_T_hB9mffbM</recordid><startdate>20170914</startdate><enddate>20170914</enddate><creator>Deng, Xin</creator><creator>Song, Laijun</creator><creator>Wei, Ying</creator><creator>Guo, Xin-bin</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170914</creationdate><title>Analysis of the expression of HAX-1 gene in human glioma</title><author>Deng, Xin ; Song, Laijun ; Wei, Ying ; Guo, Xin-bin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-54ed0dd071286870c1c9f896adba09dee1ae588a5b21a23b26ee6c204eb8a7843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adaptor Proteins, Signal Transducing - metabolism</topic><topic>Aged</topic><topic>Astrocytes</topic><topic>Cell Line, Tumor</topic><topic>Central Nervous System Neoplasms - metabolism</topic><topic>Central Nervous System Neoplasms - pathology</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Glioma</topic><topic>Glioma - metabolism</topic><topic>Glioma - pathology</topic><topic>HAX-1</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prognosis</topic><topic>Quantitative PCR</topic><topic>Survival Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Deng, Xin</creatorcontrib><creatorcontrib>Song, Laijun</creatorcontrib><creatorcontrib>Wei, Ying</creatorcontrib><creatorcontrib>Guo, Xin-bin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Deng, Xin</au><au>Song, Laijun</au><au>Wei, Ying</au><au>Guo, Xin-bin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of the expression of HAX-1 gene in human glioma</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2017-09-14</date><risdate>2017</risdate><volume>657</volume><spage>189</spage><epage>193</epage><pages>189-193</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><abstract>Glioma, as the most common aggressive malignant tumor in the central nervous system, is still an insurmountable issue in neural diseases. 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| ispartof | Neuroscience letters, 2017-09, Vol.657, p.189-193 |
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| subjects | Adaptor Proteins, Signal Transducing - metabolism Aged Astrocytes Cell Line, Tumor Central Nervous System Neoplasms - metabolism Central Nervous System Neoplasms - pathology Disease Progression Female Glioma Glioma - metabolism Glioma - pathology HAX-1 Humans Immunohistochemistry Male Middle Aged Prognosis Quantitative PCR Survival Analysis |
| title | Analysis of the expression of HAX-1 gene in human glioma |
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