Oestradiol-releasing Biodegradable Mesh Stimulates Collagen Production and Angiogenesis: An Approach to Improving Biomaterial Integration in Pelvic Floor Repair

Abstract Background Polypropylene meshes cause severe complications in some patients. Materials that are biomechanically compatible and can better integrate into host tissues are urgently needed. Objective To design an oestradiol-releasing electrospun poly- l -lactic acid (PLA) mesh and evaluate its...

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Veröffentlicht in:	European urology focus 2019-03, Vol.5 (2), p.280-289
Hauptverfasser:	Mangır, Naşide, Hillary, Christopher J, Chapple, Christopher R, MacNeil, Sheila
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Biocompatible Materials - therapeutic use Chorioallantoic Membrane - blood supply Chorioallantoic Membrane - drug effects Collagen - drug effects Elastin - metabolism Estradiol - adverse effects Estradiol - therapeutic use Extracellular Matrix - drug effects Extracellular Matrix - physiology Female Humans Mesh complications Microscopy, Electron, Scanning - methods Neovascularization, Physiologic - drug effects Neovascularization, Physiologic - physiology Oestradiol Pelvic Floor - pathology Pelvic organ prolapse Pelvic Organ Prolapse - surgery Polylactic acid Polypropylenes - adverse effects Stress urinary incontinence Surgical Mesh - adverse effects Tissue Engineering Treatment Outcome Urinary Incontinence, Stress - prevention & control Urinary Incontinence, Stress - surgery Urology
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