Insecticide resistance, associated mechanisms and fitness aspects in two Brazilian Stegomyia aegypti (= Aedes aegypti) populations
In Brazil, insecticide resistance in Stegomyia aegypti (= Aedes aegypti) (Diptera: Culicidae) populations to pyrethroids and to the organophosphate (OP) temephos is disseminated. Currently, insect growth regulators (IGRs) and the OP malathion are employed against larvae and adults, respectively. Bio...
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| Veröffentlicht in: | Medical and veterinary entomology 2017-12, Vol.31 (4), p.340-350 |
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| creator | VIANA‐MEDEIROS, P. F. BELLINATO, D. F. MARTINS, A. J. VALLE, D. |
| description | In Brazil, insecticide resistance in Stegomyia aegypti (= Aedes aegypti) (Diptera: Culicidae) populations to pyrethroids and to the organophosphate (OP) temephos is disseminated. Currently, insect growth regulators (IGRs) and the OP malathion are employed against larvae and adults, respectively. Bioassays with mosquitoes from two northeast municipalities, Crato and Aracaju, revealed, in both populations, susceptibility to IGRs and malathion (RR95 ≤ 2.0), confirming the effectiveness of these compounds. By contrast, temephos and deltamethrin (pyrethroid) resistance levels were high (RR95 > 10), which is consistent with the use of intense chemical control. In Crato, RR95 values were > 50 for both compounds. Knock‐down‐resistant (kdr) mutants in the voltage‐gated sodium channel, the pyrethroid target site, were found in 43 and 32%, respectively, of Aracaju and Crato mosquitoes. Biochemical assays revealed higher metabolic resistance activity (esterases, mixed function oxidases and glutathione‐S‐transferases) at Aracaju. With respect to fitness aspects, mating effectiveness was equivalently impaired in both populations, but Aracaju mosquitoes showed more damaging effects in terms of longer larval development, decreased bloodmeal acceptance, reduced engorgement and lower numbers of eggs laid per female. Compared with mosquitoes in Crato, Aracaju mosquitoes exhibited lower OP and pyrethroid RR95, increased activity of detoxifying enzymes and greater effect on fitness. The potential relationship between insecticide resistance mechanisms and mosquito viability is discussed. |
| doi_str_mv | 10.1111/mve.12241 |
| format | Article |
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F. ; BELLINATO, D. F. ; MARTINS, A. J. ; VALLE, D.</creator><creatorcontrib>VIANA‐MEDEIROS, P. F. ; BELLINATO, D. F. ; MARTINS, A. J. ; VALLE, D.</creatorcontrib><description>In Brazil, insecticide resistance in Stegomyia aegypti (= Aedes aegypti) (Diptera: Culicidae) populations to pyrethroids and to the organophosphate (OP) temephos is disseminated. Currently, insect growth regulators (IGRs) and the OP malathion are employed against larvae and adults, respectively. Bioassays with mosquitoes from two northeast municipalities, Crato and Aracaju, revealed, in both populations, susceptibility to IGRs and malathion (RR95 ≤ 2.0), confirming the effectiveness of these compounds. By contrast, temephos and deltamethrin (pyrethroid) resistance levels were high (RR95 > 10), which is consistent with the use of intense chemical control. In Crato, RR95 values were > 50 for both compounds. Knock‐down‐resistant (kdr) mutants in the voltage‐gated sodium channel, the pyrethroid target site, were found in 43 and 32%, respectively, of Aracaju and Crato mosquitoes. Biochemical assays revealed higher metabolic resistance activity (esterases, mixed function oxidases and glutathione‐S‐transferases) at Aracaju. With respect to fitness aspects, mating effectiveness was equivalently impaired in both populations, but Aracaju mosquitoes showed more damaging effects in terms of longer larval development, decreased bloodmeal acceptance, reduced engorgement and lower numbers of eggs laid per female. Compared with mosquitoes in Crato, Aracaju mosquitoes exhibited lower OP and pyrethroid RR95, increased activity of detoxifying enzymes and greater effect on fitness. The potential relationship between insecticide resistance mechanisms and mosquito viability is discussed.</description><identifier>ISSN: 0269-283X</identifier><identifier>EISSN: 1365-2915</identifier><identifier>DOI: 10.1111/mve.12241</identifier><identifier>PMID: 28752548</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Aedes - drug effects ; Aedes - genetics ; Aedes - growth & development ; Aedes - physiology ; Aedes aegypti ; Animals ; Brazil ; Chemical control ; Culicidae ; Deltamethrin ; diflubenzuron ; Eggs ; Engorgement ; Female ; Fitness ; Genetic Fitness ; Glutathione ; Growth regulators ; insecticide resistance ; Insecticide Resistance - genetics ; Insecticides ; Insecticides - pharmacology ; Juvenile Hormones - pharmacology ; Larva - drug effects ; Larva - genetics ; Larva - growth & development ; Larva - physiology ; Malathion ; Malathion - pharmacology ; Male ; Mating ; Mosquitoes ; Nitriles - pharmacology ; organophosphate ; Pesticide resistance ; Pyrethrins - pharmacology ; pyrethroid ; Pyrethroids ; Reproduction ; resistance mechanisms ; Sodium channels (voltage-gated) ; Stegomyia aegypti ; Stegomyia aegypti (= Aedes aegypti) ; Temefos - pharmacology</subject><ispartof>Medical and veterinary entomology, 2017-12, Vol.31 (4), p.340-350</ispartof><rights>2017 The Authors. published by John Wiley & Sons Ltd on behalf of The Royal Entomological Society.</rights><rights>2017 The Authors. 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F.</creatorcontrib><creatorcontrib>BELLINATO, D. F.</creatorcontrib><creatorcontrib>MARTINS, A. J.</creatorcontrib><creatorcontrib>VALLE, D.</creatorcontrib><title>Insecticide resistance, associated mechanisms and fitness aspects in two Brazilian Stegomyia aegypti (= Aedes aegypti) populations</title><title>Medical and veterinary entomology</title><addtitle>Med Vet Entomol</addtitle><description>In Brazil, insecticide resistance in Stegomyia aegypti (= Aedes aegypti) (Diptera: Culicidae) populations to pyrethroids and to the organophosphate (OP) temephos is disseminated. Currently, insect growth regulators (IGRs) and the OP malathion are employed against larvae and adults, respectively. Bioassays with mosquitoes from two northeast municipalities, Crato and Aracaju, revealed, in both populations, susceptibility to IGRs and malathion (RR95 ≤ 2.0), confirming the effectiveness of these compounds. By contrast, temephos and deltamethrin (pyrethroid) resistance levels were high (RR95 > 10), which is consistent with the use of intense chemical control. In Crato, RR95 values were > 50 for both compounds. Knock‐down‐resistant (kdr) mutants in the voltage‐gated sodium channel, the pyrethroid target site, were found in 43 and 32%, respectively, of Aracaju and Crato mosquitoes. Biochemical assays revealed higher metabolic resistance activity (esterases, mixed function oxidases and glutathione‐S‐transferases) at Aracaju. With respect to fitness aspects, mating effectiveness was equivalently impaired in both populations, but Aracaju mosquitoes showed more damaging effects in terms of longer larval development, decreased bloodmeal acceptance, reduced engorgement and lower numbers of eggs laid per female. Compared with mosquitoes in Crato, Aracaju mosquitoes exhibited lower OP and pyrethroid RR95, increased activity of detoxifying enzymes and greater effect on fitness. The potential relationship between insecticide resistance mechanisms and mosquito viability is discussed.</description><subject>Aedes - drug effects</subject><subject>Aedes - genetics</subject><subject>Aedes - growth & development</subject><subject>Aedes - physiology</subject><subject>Aedes aegypti</subject><subject>Animals</subject><subject>Brazil</subject><subject>Chemical control</subject><subject>Culicidae</subject><subject>Deltamethrin</subject><subject>diflubenzuron</subject><subject>Eggs</subject><subject>Engorgement</subject><subject>Female</subject><subject>Fitness</subject><subject>Genetic Fitness</subject><subject>Glutathione</subject><subject>Growth regulators</subject><subject>insecticide resistance</subject><subject>Insecticide Resistance - genetics</subject><subject>Insecticides</subject><subject>Insecticides - pharmacology</subject><subject>Juvenile Hormones - pharmacology</subject><subject>Larva - drug effects</subject><subject>Larva - genetics</subject><subject>Larva - growth & development</subject><subject>Larva - physiology</subject><subject>Malathion</subject><subject>Malathion - pharmacology</subject><subject>Male</subject><subject>Mating</subject><subject>Mosquitoes</subject><subject>Nitriles - pharmacology</subject><subject>organophosphate</subject><subject>Pesticide resistance</subject><subject>Pyrethrins - pharmacology</subject><subject>pyrethroid</subject><subject>Pyrethroids</subject><subject>Reproduction</subject><subject>resistance mechanisms</subject><subject>Sodium channels (voltage-gated)</subject><subject>Stegomyia aegypti</subject><subject>Stegomyia aegypti (= Aedes aegypti)</subject><subject>Temefos - pharmacology</subject><issn>0269-283X</issn><issn>1365-2915</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNpdkU1v1jAMxyMEYs8GB74AisRlk-jWpEnaHDhs0xiThjjwIm6Vn8Qdmdq01OmmhxMHLnzNfRLCXjjgg23ZP1uJ_4y9EOW-yHYwXOG-kFKJR2wlKqMLaYV-zFalNLaQTfV1i20TXZalqK2UT9mWbGottWpW7NdZJHQpuOCRz0iBEkSHrzkQjS5AQs8HdN8gBhqIQ_S8Cyki5ZymPEk8RJ6uR340w4_QB4j8Y8KLcdgE4IAXmykFvvvm5ufvQ_RID6U9Po3T0kMKY6Rn7EkHPeHz-7jDPr89-XT8rjj_cHp2fHheTJVQonCm1HZd1rXSwq-tERq1z1_UNTZd50AYcI0C4xvllepqUM7oEq3qvAXbYLXDdu_2TvP4fUFK7RDIYd9DxHGhVliptDV5KKOv_kMvx2WO-XWZMmUls68y9fKeWtYD-naawwDzpn24bwYO7oDr0OPmX1-U7V_h2ixceytc-_7LyW1S_QFkm4zs</recordid><startdate>201712</startdate><enddate>201712</enddate><creator>VIANA‐MEDEIROS, P. F.</creator><creator>BELLINATO, D. F.</creator><creator>MARTINS, A. J.</creator><creator>VALLE, D.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QG</scope><scope>7SS</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2976-9895</orcidid></search><sort><creationdate>201712</creationdate><title>Insecticide resistance, associated mechanisms and fitness aspects in two Brazilian Stegomyia aegypti (= Aedes aegypti) populations</title><author>VIANA‐MEDEIROS, P. F. ; BELLINATO, D. F. ; MARTINS, A. J. ; VALLE, D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p3141-c6059b077451db9615e5d26957e8ffca16ac84a6d84d44f7a4c650e94fd9a98e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aedes - drug effects</topic><topic>Aedes - genetics</topic><topic>Aedes - growth & development</topic><topic>Aedes - physiology</topic><topic>Aedes aegypti</topic><topic>Animals</topic><topic>Brazil</topic><topic>Chemical control</topic><topic>Culicidae</topic><topic>Deltamethrin</topic><topic>diflubenzuron</topic><topic>Eggs</topic><topic>Engorgement</topic><topic>Female</topic><topic>Fitness</topic><topic>Genetic Fitness</topic><topic>Glutathione</topic><topic>Growth regulators</topic><topic>insecticide resistance</topic><topic>Insecticide Resistance - genetics</topic><topic>Insecticides</topic><topic>Insecticides - pharmacology</topic><topic>Juvenile Hormones - pharmacology</topic><topic>Larva - drug effects</topic><topic>Larva - genetics</topic><topic>Larva - growth & development</topic><topic>Larva - physiology</topic><topic>Malathion</topic><topic>Malathion - pharmacology</topic><topic>Male</topic><topic>Mating</topic><topic>Mosquitoes</topic><topic>Nitriles - pharmacology</topic><topic>organophosphate</topic><topic>Pesticide resistance</topic><topic>Pyrethrins - pharmacology</topic><topic>pyrethroid</topic><topic>Pyrethroids</topic><topic>Reproduction</topic><topic>resistance mechanisms</topic><topic>Sodium channels (voltage-gated)</topic><topic>Stegomyia aegypti</topic><topic>Stegomyia aegypti (= Aedes aegypti)</topic><topic>Temefos - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>VIANA‐MEDEIROS, P. F.</creatorcontrib><creatorcontrib>BELLINATO, D. F.</creatorcontrib><creatorcontrib>MARTINS, A. J.</creatorcontrib><creatorcontrib>VALLE, D.</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Wiley Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Animal Behavior Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Medical and veterinary entomology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>VIANA‐MEDEIROS, P. F.</au><au>BELLINATO, D. F.</au><au>MARTINS, A. J.</au><au>VALLE, D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Insecticide resistance, associated mechanisms and fitness aspects in two Brazilian Stegomyia aegypti (= Aedes aegypti) populations</atitle><jtitle>Medical and veterinary entomology</jtitle><addtitle>Med Vet Entomol</addtitle><date>2017-12</date><risdate>2017</risdate><volume>31</volume><issue>4</issue><spage>340</spage><epage>350</epage><pages>340-350</pages><issn>0269-283X</issn><eissn>1365-2915</eissn><abstract>In Brazil, insecticide resistance in Stegomyia aegypti (= Aedes aegypti) (Diptera: Culicidae) populations to pyrethroids and to the organophosphate (OP) temephos is disseminated. Currently, insect growth regulators (IGRs) and the OP malathion are employed against larvae and adults, respectively. Bioassays with mosquitoes from two northeast municipalities, Crato and Aracaju, revealed, in both populations, susceptibility to IGRs and malathion (RR95 ≤ 2.0), confirming the effectiveness of these compounds. By contrast, temephos and deltamethrin (pyrethroid) resistance levels were high (RR95 > 10), which is consistent with the use of intense chemical control. In Crato, RR95 values were > 50 for both compounds. Knock‐down‐resistant (kdr) mutants in the voltage‐gated sodium channel, the pyrethroid target site, were found in 43 and 32%, respectively, of Aracaju and Crato mosquitoes. Biochemical assays revealed higher metabolic resistance activity (esterases, mixed function oxidases and glutathione‐S‐transferases) at Aracaju. With respect to fitness aspects, mating effectiveness was equivalently impaired in both populations, but Aracaju mosquitoes showed more damaging effects in terms of longer larval development, decreased bloodmeal acceptance, reduced engorgement and lower numbers of eggs laid per female. Compared with mosquitoes in Crato, Aracaju mosquitoes exhibited lower OP and pyrethroid RR95, increased activity of detoxifying enzymes and greater effect on fitness. The potential relationship between insecticide resistance mechanisms and mosquito viability is discussed.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>28752548</pmid><doi>10.1111/mve.12241</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-2976-9895</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Aedes - drug effects Aedes - genetics Aedes - growth & development Aedes - physiology Aedes aegypti Animals Brazil Chemical control Culicidae Deltamethrin diflubenzuron Eggs Engorgement Female Fitness Genetic Fitness Glutathione Growth regulators insecticide resistance Insecticide Resistance - genetics Insecticides Insecticides - pharmacology Juvenile Hormones - pharmacology Larva - drug effects Larva - genetics Larva - growth & development Larva - physiology Malathion Malathion - pharmacology Male Mating Mosquitoes Nitriles - pharmacology organophosphate Pesticide resistance Pyrethrins - pharmacology pyrethroid Pyrethroids Reproduction resistance mechanisms Sodium channels (voltage-gated) Stegomyia aegypti Stegomyia aegypti (= Aedes aegypti) Temefos - pharmacology |
| title | Insecticide resistance, associated mechanisms and fitness aspects in two Brazilian Stegomyia aegypti (= Aedes aegypti) populations |
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