Krüppel-like factor 4 acts as a potential therapeutic target of Sijunzi decoction for treatment of colorectal cancer
Sijunzi decoction (SJZD) is a traditional Chinese medicine prescription for the prevention and treatment of colorectal cancer. Our study is aimed to identify the potential therapeutic target of SJZD. Microarray analysis was performed on the patients with colorectal cancer under treatment of SJZD. Th...
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| Veröffentlicht in: | Cancer gene therapy 2017-09, Vol.24 (9), p.361-366 |
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| creator | Jie, Y He, W Yang, X Chen, W |
| description | Sijunzi decoction (SJZD) is a traditional Chinese medicine prescription for the prevention and treatment of colorectal cancer. Our study is aimed to identify the potential therapeutic target of SJZD. Microarray analysis was performed on the patients with colorectal cancer under treatment of SJZD. The mRNA targets of SJZD were predicted by BATMAN-TCM database and were further identified by integrated analysis of expression data from TCGA. The correlation of gene expression and clinical characteristics was analyzed. Microarray analysis indicated that Krüppel-like factor 4 (KLF4) was significantly upregulated after intervention of SJZD. BATMAN-TCM prediction showed that KLF4 was an mRNA target of SJZD and it was downregulated in colorectal cancer by integrated analysis of expression data from TCGA. KLF4 may act as an administered indicator to assess whether adjuvant postoperative pharmaceutical therapy is needed for patients with colorectal cancer. Low KLF4 expression was significantly correlated with reductions of overall survival and recurrence rate. Our results suggested that KLF4 may be the potential therapeutic target of SJZD for the treatment of colorectal cancer. |
| doi_str_mv | 10.1038/cgt.2017.25 |
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Our study is aimed to identify the potential therapeutic target of SJZD. Microarray analysis was performed on the patients with colorectal cancer under treatment of SJZD. The mRNA targets of SJZD were predicted by BATMAN-TCM database and were further identified by integrated analysis of expression data from TCGA. The correlation of gene expression and clinical characteristics was analyzed. Microarray analysis indicated that Krüppel-like factor 4 (KLF4) was significantly upregulated after intervention of SJZD. BATMAN-TCM prediction showed that KLF4 was an mRNA target of SJZD and it was downregulated in colorectal cancer by integrated analysis of expression data from TCGA. KLF4 may act as an administered indicator to assess whether adjuvant postoperative pharmaceutical therapy is needed for patients with colorectal cancer. Low KLF4 expression was significantly correlated with reductions of overall survival and recurrence rate. Our results suggested that KLF4 may be the potential therapeutic target of SJZD for the treatment of colorectal cancer.</description><identifier>ISSN: 0929-1903</identifier><identifier>EISSN: 1476-5500</identifier><identifier>DOI: 10.1038/cgt.2017.25</identifier><identifier>PMID: 28752861</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>38/39 ; 38/61 ; 631/67 ; 631/67/1059 ; Biomedical and Life Sciences ; Biomedicine ; Cancer ; Care and treatment ; Chinese medicine ; Colorectal cancer ; Colorectal carcinoma ; Colorectal Neoplasms - drug therapy ; Colorectal Neoplasms - metabolism ; Colorectal Neoplasms - mortality ; Colorectal Neoplasms - pathology ; Data processing ; DNA microarrays ; Drug therapy ; Drugs, Chinese Herbal - administration & dosage ; Female ; Gene Expression ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic - drug effects ; Gene Therapy ; Health aspects ; Humans ; KLF4 protein ; Kruppel-Like Transcription Factors - biosynthesis ; Male ; Medicine, Chinese ; Medicine, Chinese Traditional - methods ; Molecular targeted therapy ; Neoplasm Proteins - metabolism ; Oligonucleotide Array Sequence Analysis ; Oncology, Experimental ; original-article ; Patients ; Prevention ; Therapeutic applications ; Therapeutic targets ; Traditional Chinese medicine ; Transcription factors ; Up-Regulation - drug effects</subject><ispartof>Cancer gene therapy, 2017-09, Vol.24 (9), p.361-366</ispartof><rights>Nature America, Inc., part of Springer Nature. 2017</rights><rights>COPYRIGHT 2017 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Sep 2017</rights><rights>Nature America, Inc., part of Springer Nature. 2017.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c681t-85ae9045cb91e8ff2276afed2fa0a576627bd85ea47689620702c9a52638b3083</citedby><cites>FETCH-LOGICAL-c681t-85ae9045cb91e8ff2276afed2fa0a576627bd85ea47689620702c9a52638b3083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28752861$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jie, Y</creatorcontrib><creatorcontrib>He, W</creatorcontrib><creatorcontrib>Yang, X</creatorcontrib><creatorcontrib>Chen, W</creatorcontrib><title>Krüppel-like factor 4 acts as a potential therapeutic target of Sijunzi decoction for treatment of colorectal cancer</title><title>Cancer gene therapy</title><addtitle>Cancer Gene Ther</addtitle><addtitle>Cancer Gene Ther</addtitle><description>Sijunzi decoction (SJZD) is a traditional Chinese medicine prescription for the prevention and treatment of colorectal cancer. 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Our results suggested that KLF4 may be the potential therapeutic target of SJZD for the treatment of colorectal cancer.</description><subject>38/39</subject><subject>38/61</subject><subject>631/67</subject><subject>631/67/1059</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer</subject><subject>Care and treatment</subject><subject>Chinese medicine</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Colorectal Neoplasms - drug therapy</subject><subject>Colorectal Neoplasms - metabolism</subject><subject>Colorectal Neoplasms - mortality</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Data processing</subject><subject>DNA microarrays</subject><subject>Drug therapy</subject><subject>Drugs, Chinese Herbal - administration & dosage</subject><subject>Female</subject><subject>Gene Expression</subject><subject>Gene Expression Profiling</subject><subject>Gene Expression Regulation, Neoplastic - 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Academic</collection><jtitle>Cancer gene therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jie, Y</au><au>He, W</au><au>Yang, X</au><au>Chen, W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Krüppel-like factor 4 acts as a potential therapeutic target of Sijunzi decoction for treatment of colorectal cancer</atitle><jtitle>Cancer gene therapy</jtitle><stitle>Cancer Gene Ther</stitle><addtitle>Cancer Gene Ther</addtitle><date>2017-09-01</date><risdate>2017</risdate><volume>24</volume><issue>9</issue><spage>361</spage><epage>366</epage><pages>361-366</pages><issn>0929-1903</issn><eissn>1476-5500</eissn><abstract>Sijunzi decoction (SJZD) is a traditional Chinese medicine prescription for the prevention and treatment of colorectal cancer. Our study is aimed to identify the potential therapeutic target of SJZD. Microarray analysis was performed on the patients with colorectal cancer under treatment of SJZD. The mRNA targets of SJZD were predicted by BATMAN-TCM database and were further identified by integrated analysis of expression data from TCGA. The correlation of gene expression and clinical characteristics was analyzed. Microarray analysis indicated that Krüppel-like factor 4 (KLF4) was significantly upregulated after intervention of SJZD. BATMAN-TCM prediction showed that KLF4 was an mRNA target of SJZD and it was downregulated in colorectal cancer by integrated analysis of expression data from TCGA. KLF4 may act as an administered indicator to assess whether adjuvant postoperative pharmaceutical therapy is needed for patients with colorectal cancer. Low KLF4 expression was significantly correlated with reductions of overall survival and recurrence rate. Our results suggested that KLF4 may be the potential therapeutic target of SJZD for the treatment of colorectal cancer.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>28752861</pmid><doi>10.1038/cgt.2017.25</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 38/39 38/61 631/67 631/67/1059 Biomedical and Life Sciences Biomedicine Cancer Care and treatment Chinese medicine Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - drug therapy Colorectal Neoplasms - metabolism Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Data processing DNA microarrays Drug therapy Drugs, Chinese Herbal - administration & dosage Female Gene Expression Gene Expression Profiling Gene Expression Regulation, Neoplastic - drug effects Gene Therapy Health aspects Humans KLF4 protein Kruppel-Like Transcription Factors - biosynthesis Male Medicine, Chinese Medicine, Chinese Traditional - methods Molecular targeted therapy Neoplasm Proteins - metabolism Oligonucleotide Array Sequence Analysis Oncology, Experimental original-article Patients Prevention Therapeutic applications Therapeutic targets Traditional Chinese medicine Transcription factors Up-Regulation - drug effects |
| title | Krüppel-like factor 4 acts as a potential therapeutic target of Sijunzi decoction for treatment of colorectal cancer |
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