The salivary peptide histatin‐1 promotes endothelial cell adhesion, migration, and angiogenesis

Saliva is a key factor that contributes to the high efficiency of wound healing in the oral mucosa. This is not only attributed to physical cues but also to the presence of specific peptides in the saliva, such as histatins. Histatin‐1 is a 38 aa antimicrobial peptide, highly enriched in human saliv...

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Veröffentlicht in:	The FASEB journal 2017-11, Vol.31 (11), p.4946-4958
Hauptverfasser:	Torres, Pedro, Díaz, Jorge, Arce, Maximiliano, Silva, Patricio, Mendoza, Pablo, Lois, Pablo, Molina‐Berríos, Alfredo, Owen, Gareth I., Palma, Verónica, Torres, Vicente A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Adhesion Angiogenesis Angiogenesis Inducing Agents - metabolism Angiogenesis Inducing Agents - pharmacology Assaying Boyden chamber Carrier Proteins - metabolism Cell adhesion Cell adhesion & migration Cell Adhesion - drug effects Cell Line Cell migration Cell Movement - drug effects Chorioallantoic membrane Cues Endosomes Endothelial cells Endothelial Cells - metabolism Endothelial Cells - pathology Fibroblasts Fibronectin GTPase Guanine Guanine nucleotide exchange factor Guanine Nucleotide Exchange Factors - metabolism Histatins - metabolism Histatins - pharmacology Humans Keratinocytes Mouth Mucosa - injuries Mouth Mucosa - metabolism Mouth Mucosa - pathology Mucosa Neovascularization, Physiologic - drug effects Peptides Rab5 rab5 GTP-Binding Proteins - metabolism rac1 GTP-Binding Protein - metabolism Rac1 protein Recruitment Saliva Salivary Proteins and Peptides - metabolism Salivary Proteins and Peptides - pharmacology Signaling Wound healing Wound Healing - drug effects
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