TRIM65 triggers β-catenin signaling via ubiquitylation of Axin1 to promote hepatocellular carcinoma

Deregulation of ubiquitin ligases contributes to the malignant progression of human cancers. Tripartite motif-containing protein 65 (TRIM65) is an E3 ubiquitin ligase and has been implicated in human diseases, but its role and clinical significance in hepatocellular carcinoma (HCC) remain unknown. H...

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Veröffentlicht in:	Journal of cell science 2017-09, Vol.130 (18), p.3108-3115
Hauptverfasser:	Yang, Yu-Feng, Zhang, Mei-Fang, Tian, Qiu-Hong, Zhang, Chris Zhiyi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axin Protein - metabolism beta Catenin - metabolism Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell Line, Tumor Cell Movement - genetics Cell Proliferation - genetics Deregulation Gene Expression Regulation, Neoplastic Hepatocellular carcinoma Liver cancer Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - pathology Male Metastases Mice, Inbred BALB C Mice, Nude Neoplasm Metastasis Signal Transduction Signaling Tissues Transcription, Genetic Treatment Outcome Tripartite Motif Proteins - genetics Tripartite Motif Proteins - metabolism Ubiquitin Ubiquitin-protein ligase Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Ubiquitination Up-Regulation - genetics β-catenin
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