Structural dynamics of wild type and mutated forms of human L1 endonuclease and insights into its sequence specific nucleic acid binding mechanism: A molecular dynamics study

The specific and non-specific recognition of DNA by L1-endonuclease. [Display omitted] •The importance of Thr192 in stabilizing the active site as well as the βB6-βB5 hairpin loop for DNA recognition.•The specificity of L1- endonuclease towards the substrate DNA containing TA junction rather than CG...

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Veröffentlicht in:	Journal of molecular graphics & modelling 2017-09, Vol.76, p.43-55
Hauptverfasser:	Rajagopalan, Muthukumaran, Balasubramanian, Sangeetha, Ramaswamy, Amutha
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites - physiology DNA - metabolism DNA bending Endonuclease Endonucleases - metabolism Humans LINE-1 Molecular Dynamics Simulation Molecular dynamics simulations Nucleic Acid Conformation Nucleic Acids - metabolism Ribonucleoprotein complex Substrate Specificity
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