Knockout of a P‐glycoprotein gene increases susceptibility to abamectin and emamectin benzoate in Spodoptera exigua

P‐glycoprotein [P‐gp or the ATP‐binding cassette transporter B1 (ABCB1)] is an important participant in multidrug resistance of cancer cells, yet the precise function of this arthropod transporter is unknown. The aim of this study was to determine the importance of P‐gp for susceptibility to insecti...

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Veröffentlicht in:	Insect molecular biology 2018-02, Vol.27 (1), p.36-45
Hauptverfasser:	Zuo, Y.‐Y., Huang, J.‐L., Wang, J., Feng, Y., Han, T.‐T., Wu, Y.‐D., Yang, Y.-H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Abamectin ABC transporter Adenosine triphosphate Agrochemicals Bioassays Cancer Chlorfenapyr Chlorpyrifos Clonal deletion CRISPR CRISPR/Cas9 Cypermethrin Gene deletion Genetic modification Glycoproteins Insecticide resistance insecticide susceptibility Insecticides Insects Multidrug resistance Nucleotides P-Glycoprotein Pesticides Phoxim Proteins Spinosad Spodoptera exigua Toxins
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