Hepatocyte‐derived exosomes promote T follicular regulatory cell expansion during hepatitis C virus infection

Hepatitis C virus (HCV) is a global health concern that can cause severe liver disease, such as cirrhosis and hepatocellular carcinoma. Control of HCV requires vigorous T‐cell responses, yet CD4+ T cells in chronic HCV patients are dysfunctional. T follicular regulatory (Tfr) cells are a subset of r...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2018-01, Vol.67 (1), p.71-85
Hauptverfasser:	Cobb, Dustin A., Kim, Ok‐Kyung, Golden‐Mason, Lucy, Rosen, Hugo R., Hahn, Young S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biopsy, Needle CD4 antigen CD4-Positive T-Lymphocytes - immunology Cell Proliferation - physiology Cells, Cultured Chronic infection Cirrhosis Exosomes Exosomes - immunology Exosomes - metabolism Flow Cytometry Hepacivirus - immunology Hepatitis Hepatitis C Hepatitis C - immunology Hepatitis C - pathology Hepatocellular carcinoma Hepatocytes Hepatocytes - immunology Hepatocytes - metabolism Hepatology Hepatoma Humans Immunohistochemistry Immunoregulation In Vitro Techniques Infections Liver Liver cancer Liver cirrhosis Liver diseases Lymphocytes B Lymphocytes T Molecular modelling Statistics, Nonparametric T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism Tonsil Transforming growth factor-b
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