Antimicrobial activity of ethylene-vinyl acetate containing bioactive filler against oral bacteria
We developed an ethylene vinyl acetate (EVA) containing surface pre-reacted glass-ionomer (S-PRG) filler, as a new mouthguard material for preventing intraoral bacterial infection. We examined its physical properties, antimicrobial activity against a major cariogenic bacterium Streptococcus mutans a...
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| Veröffentlicht in: | Dental Materials Journal 2017/11/27, Vol.36(6), pp.784-790 |
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| container_title | Dental Materials Journal |
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| creator | NAGAI, Kosuke DOMON, Hisanori ODA, Masataka SHIRAI, Tomoe OHSUMI, Tatsuya TERAO, Yutaka ARAI, Yoshiaki |
| description | We developed an ethylene vinyl acetate (EVA) containing surface pre-reacted glass-ionomer (S-PRG) filler, as a new mouthguard material for preventing intraoral bacterial infection. We examined its physical properties, antimicrobial activity against a major cariogenic bacterium Streptococcus mutans and a periodontopathogen Porphyromonas gingivalis, and its cytotoxicity toward human gingival epithelial cells. S-PRG filler was added to EVA copolymer at 5, 10, 20, or 40 wt% and was processed into disc-shaped test specimens. Only minor differences between the Shore hardness and rebound resilience properties of EVA materials with and without the S-PRG filler were observed. The specimens with S-PRG filler showed bacteriostatic activity toward S. mutans and P. gingivalis and inhibited S. mutans biofilm formation. No cytotoxicity against the gingival epithelial cells was observed. Our findings show that EVA containing S-PRG filler has antimicrobial activity toward pathogenic oral bacteria and may be an effective material for maintaining the oral health of athletes. |
| doi_str_mv | 10.4012/dmj.2016-321 |
| format | Article |
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We examined its physical properties, antimicrobial activity against a major cariogenic bacterium Streptococcus mutans and a periodontopathogen Porphyromonas gingivalis, and its cytotoxicity toward human gingival epithelial cells. S-PRG filler was added to EVA copolymer at 5, 10, 20, or 40 wt% and was processed into disc-shaped test specimens. Only minor differences between the Shore hardness and rebound resilience properties of EVA materials with and without the S-PRG filler were observed. The specimens with S-PRG filler showed bacteriostatic activity toward S. mutans and P. gingivalis and inhibited S. mutans biofilm formation. No cytotoxicity against the gingival epithelial cells was observed. Our findings show that EVA containing S-PRG filler has antimicrobial activity toward pathogenic oral bacteria and may be an effective material for maintaining the oral health of athletes.</description><identifier>ISSN: 0287-4547</identifier><identifier>EISSN: 1881-1361</identifier><identifier>DOI: 10.4012/dmj.2016-321</identifier><identifier>PMID: 28747597</identifier><language>eng</language><publisher>Japan: The Japanese Society for Dental Materials and Devices</publisher><subject>Acetic acid ; Anti-Infective Agents - pharmacology ; Antiinfectives and antibacterials ; Antimicrobial activity ; Antimicrobial agents ; Athletes ; Bacteria ; Biocompatibility ; Biofilms ; Cell Line ; Cytotoxicity ; Dentistry ; Epithelial cells ; Epithelial Cells - drug effects ; Ethylene ; Ethylene vinyl acetates ; Ethylenes - pharmacology ; Gingiva - cytology ; Glass Ionomer Cements - pharmacology ; Hardness ; Humans ; Materials Testing ; Mouth Protectors ; Mouthguard ; Periodontics ; Physical properties ; Physical property ; Porphyromonas gingivalis ; Porphyromonas gingivalis - drug effects ; Protective equipment ; Streptococcus infections ; Streptococcus mutans ; Streptococcus mutans - drug effects ; Surface pre-reacted glass-ionomer filler ; Surface Properties ; Toxicity ; Vinyl acetate ; Vinyl Compounds - pharmacology</subject><ispartof>Dental Materials Journal, 2017/11/27, Vol.36(6), pp.784-790</ispartof><rights>2017 The Japanese Society for Dental Materials and Devices</rights><rights>Copyright Japan Science and Technology Agency 2017</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c671t-e25a9ab1f6ef58f31c4e110d11ff7fb48bf7c9930cb4b554f4a0f532a8a432a23</citedby><cites>FETCH-LOGICAL-c671t-e25a9ab1f6ef58f31c4e110d11ff7fb48bf7c9930cb4b554f4a0f532a8a432a23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28747597$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>NAGAI, Kosuke</creatorcontrib><creatorcontrib>DOMON, Hisanori</creatorcontrib><creatorcontrib>ODA, Masataka</creatorcontrib><creatorcontrib>SHIRAI, Tomoe</creatorcontrib><creatorcontrib>OHSUMI, Tatsuya</creatorcontrib><creatorcontrib>TERAO, Yutaka</creatorcontrib><creatorcontrib>ARAI, Yoshiaki</creatorcontrib><creatorcontrib>Temporomandibular Joint Clinic</creatorcontrib><creatorcontrib>Department of Oral Health Science</creatorcontrib><creatorcontrib>Operative Dentistry and Endodontics</creatorcontrib><creatorcontrib>Niigata University Medical and Dental Hospital</creatorcontrib><creatorcontrib>Niigata University Graduate School of Medical and Dental Sciences</creatorcontrib><creatorcontrib>Division of Cariology</creatorcontrib><creatorcontrib>Division of Microbiology and Infectious Diseases</creatorcontrib><title>Antimicrobial activity of ethylene-vinyl acetate containing bioactive filler against oral bacteria</title><title>Dental Materials Journal</title><addtitle>Dent. Mater. J.</addtitle><description>We developed an ethylene vinyl acetate (EVA) containing surface pre-reacted glass-ionomer (S-PRG) filler, as a new mouthguard material for preventing intraoral bacterial infection. We examined its physical properties, antimicrobial activity against a major cariogenic bacterium Streptococcus mutans and a periodontopathogen Porphyromonas gingivalis, and its cytotoxicity toward human gingival epithelial cells. S-PRG filler was added to EVA copolymer at 5, 10, 20, or 40 wt% and was processed into disc-shaped test specimens. Only minor differences between the Shore hardness and rebound resilience properties of EVA materials with and without the S-PRG filler were observed. The specimens with S-PRG filler showed bacteriostatic activity toward S. mutans and P. gingivalis and inhibited S. mutans biofilm formation. No cytotoxicity against the gingival epithelial cells was observed. Our findings show that EVA containing S-PRG filler has antimicrobial activity toward pathogenic oral bacteria and may be an effective material for maintaining the oral health of athletes.</description><subject>Acetic acid</subject><subject>Anti-Infective Agents - pharmacology</subject><subject>Antiinfectives and antibacterials</subject><subject>Antimicrobial activity</subject><subject>Antimicrobial agents</subject><subject>Athletes</subject><subject>Bacteria</subject><subject>Biocompatibility</subject><subject>Biofilms</subject><subject>Cell Line</subject><subject>Cytotoxicity</subject><subject>Dentistry</subject><subject>Epithelial cells</subject><subject>Epithelial Cells - drug effects</subject><subject>Ethylene</subject><subject>Ethylene vinyl acetates</subject><subject>Ethylenes - pharmacology</subject><subject>Gingiva - cytology</subject><subject>Glass Ionomer Cements - pharmacology</subject><subject>Hardness</subject><subject>Humans</subject><subject>Materials Testing</subject><subject>Mouth Protectors</subject><subject>Mouthguard</subject><subject>Periodontics</subject><subject>Physical properties</subject><subject>Physical property</subject><subject>Porphyromonas gingivalis</subject><subject>Porphyromonas gingivalis - drug effects</subject><subject>Protective equipment</subject><subject>Streptococcus infections</subject><subject>Streptococcus mutans</subject><subject>Streptococcus mutans - drug effects</subject><subject>Surface pre-reacted glass-ionomer filler</subject><subject>Surface Properties</subject><subject>Toxicity</subject><subject>Vinyl acetate</subject><subject>Vinyl Compounds - pharmacology</subject><issn>0287-4547</issn><issn>1881-1361</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkM1v1DAQxS0EokvhxhlF4sKBFDt2_HFsKyhIlbjA2bKd8dYrxymOt1L-e5ymXSQuY8nvN2-eHkLvCb5gmHRfhvFw0WHCW9qRF2hHpCQtoZy8RDvcSdGynokz9GaeDxgzxaV8jc7qPxO9EjtkL1MJY3B5ssHExrgSHkJZmsk3UO6WCAnah5CWVYJiCjRuSsWEFNK-sWF6XIDGhxghN2Zflbk0U65etmqQg3mLXnkTZ3j39J6j39--_rr-3t7-vPlxfXnbOi5IaaHrjTKWeA6-l54Sx4AQPBDivfCWSeuFU4piZ5nte-aZwb6nnZGG1dnRc_Rp873P058jzEWPYXYQo0kwHWdNVMd6RXpGKvrxP_QwHXOq6XStkjHOsFgNP29UbWeeM3h9n8No8qIJ1mv3una_LnBdu6_4hyfTox1hOMHPZVfgZgOqGpyJU4ohwb_Tw4IHSJul0BhTjrnGhGosJKtD4U4pqRSvTleb02EuZg-nUyaX4CI85qJc83U85zuJ7s5kDYn-BclUrnA</recordid><startdate>2017</startdate><enddate>2017</enddate><creator>NAGAI, Kosuke</creator><creator>DOMON, Hisanori</creator><creator>ODA, Masataka</creator><creator>SHIRAI, Tomoe</creator><creator>OHSUMI, Tatsuya</creator><creator>TERAO, Yutaka</creator><creator>ARAI, Yoshiaki</creator><general>The Japanese Society for Dental Materials and Devices</general><general>Japanese Society for Dental Materials and Devices</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QP</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>2017</creationdate><title>Antimicrobial activity of ethylene-vinyl acetate containing bioactive filler against oral bacteria</title><author>NAGAI, Kosuke ; DOMON, Hisanori ; ODA, Masataka ; SHIRAI, Tomoe ; OHSUMI, Tatsuya ; TERAO, Yutaka ; ARAI, Yoshiaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c671t-e25a9ab1f6ef58f31c4e110d11ff7fb48bf7c9930cb4b554f4a0f532a8a432a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Acetic acid</topic><topic>Anti-Infective Agents - pharmacology</topic><topic>Antiinfectives and antibacterials</topic><topic>Antimicrobial activity</topic><topic>Antimicrobial agents</topic><topic>Athletes</topic><topic>Bacteria</topic><topic>Biocompatibility</topic><topic>Biofilms</topic><topic>Cell Line</topic><topic>Cytotoxicity</topic><topic>Dentistry</topic><topic>Epithelial cells</topic><topic>Epithelial Cells - drug effects</topic><topic>Ethylene</topic><topic>Ethylene vinyl acetates</topic><topic>Ethylenes - pharmacology</topic><topic>Gingiva - cytology</topic><topic>Glass Ionomer Cements - pharmacology</topic><topic>Hardness</topic><topic>Humans</topic><topic>Materials Testing</topic><topic>Mouth Protectors</topic><topic>Mouthguard</topic><topic>Periodontics</topic><topic>Physical properties</topic><topic>Physical property</topic><topic>Porphyromonas gingivalis</topic><topic>Porphyromonas gingivalis - drug effects</topic><topic>Protective equipment</topic><topic>Streptococcus infections</topic><topic>Streptococcus mutans</topic><topic>Streptococcus mutans - drug effects</topic><topic>Surface pre-reacted glass-ionomer filler</topic><topic>Surface Properties</topic><topic>Toxicity</topic><topic>Vinyl acetate</topic><topic>Vinyl Compounds - pharmacology</topic><toplevel>online_resources</toplevel><creatorcontrib>NAGAI, Kosuke</creatorcontrib><creatorcontrib>DOMON, Hisanori</creatorcontrib><creatorcontrib>ODA, Masataka</creatorcontrib><creatorcontrib>SHIRAI, Tomoe</creatorcontrib><creatorcontrib>OHSUMI, Tatsuya</creatorcontrib><creatorcontrib>TERAO, Yutaka</creatorcontrib><creatorcontrib>ARAI, Yoshiaki</creatorcontrib><creatorcontrib>Temporomandibular Joint Clinic</creatorcontrib><creatorcontrib>Department of Oral Health Science</creatorcontrib><creatorcontrib>Operative Dentistry and Endodontics</creatorcontrib><creatorcontrib>Niigata University Medical and Dental Hospital</creatorcontrib><creatorcontrib>Niigata University Graduate School of Medical and Dental Sciences</creatorcontrib><creatorcontrib>Division of Cariology</creatorcontrib><creatorcontrib>Division of Microbiology and Infectious Diseases</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - 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Mater. J.</addtitle><date>2017</date><risdate>2017</risdate><volume>36</volume><issue>6</issue><spage>784</spage><epage>790</epage><pages>784-790</pages><issn>0287-4547</issn><eissn>1881-1361</eissn><abstract>We developed an ethylene vinyl acetate (EVA) containing surface pre-reacted glass-ionomer (S-PRG) filler, as a new mouthguard material for preventing intraoral bacterial infection. We examined its physical properties, antimicrobial activity against a major cariogenic bacterium Streptococcus mutans and a periodontopathogen Porphyromonas gingivalis, and its cytotoxicity toward human gingival epithelial cells. S-PRG filler was added to EVA copolymer at 5, 10, 20, or 40 wt% and was processed into disc-shaped test specimens. Only minor differences between the Shore hardness and rebound resilience properties of EVA materials with and without the S-PRG filler were observed. The specimens with S-PRG filler showed bacteriostatic activity toward S. mutans and P. gingivalis and inhibited S. mutans biofilm formation. No cytotoxicity against the gingival epithelial cells was observed. Our findings show that EVA containing S-PRG filler has antimicrobial activity toward pathogenic oral bacteria and may be an effective material for maintaining the oral health of athletes.</abstract><cop>Japan</cop><pub>The Japanese Society for Dental Materials and Devices</pub><pmid>28747597</pmid><doi>10.4012/dmj.2016-321</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Dental Materials Journal, 2017/11/27, Vol.36(6), pp.784-790 |
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| language | eng |
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| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Acetic acid Anti-Infective Agents - pharmacology Antiinfectives and antibacterials Antimicrobial activity Antimicrobial agents Athletes Bacteria Biocompatibility Biofilms Cell Line Cytotoxicity Dentistry Epithelial cells Epithelial Cells - drug effects Ethylene Ethylene vinyl acetates Ethylenes - pharmacology Gingiva - cytology Glass Ionomer Cements - pharmacology Hardness Humans Materials Testing Mouth Protectors Mouthguard Periodontics Physical properties Physical property Porphyromonas gingivalis Porphyromonas gingivalis - drug effects Protective equipment Streptococcus infections Streptococcus mutans Streptococcus mutans - drug effects Surface pre-reacted glass-ionomer filler Surface Properties Toxicity Vinyl acetate Vinyl Compounds - pharmacology |
| title | Antimicrobial activity of ethylene-vinyl acetate containing bioactive filler against oral bacteria |
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