Low-Dose Ionizing Radiation Exposure, Oxidative Stress and Epigenetic Programing of Health and Disease
Ionizing radiation exposure from medical diagnostic imaging has greatly increased over the last few decades. Approximately 80% of patients who undergo medical imaging are exposed to low-dose ionizing radiation (LDIR). Although there is widespread consensus regarding the harmful effects of high doses...
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| Veröffentlicht in: | Radiation research 2017-10, Vol.188 (4.2), p.525-538 |
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| container_title | Radiation research |
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| creator | Tharmalingam, Sujeenthar Sreetharan, Shayenthiran Kulesza, Adomas V. Boreham, Douglas R. Tai, T. C. |
| description | Ionizing radiation exposure from medical diagnostic imaging has greatly increased over the last few decades. Approximately 80% of patients who undergo medical imaging are exposed to low-dose ionizing radiation (LDIR). Although there is widespread consensus regarding the harmful effects of high doses of radiation, the biological effects of low-linear energy transfer (LET) LDIR is not well understood. LDIR is known to promote oxidative stress, however, these levels may not be large enough to result in genomic mutations. There is emerging evidence that oxidative stress causes heritable modifications via epigenetic mechanisms (DNA methylation, histone modification, noncoding RNA regulation). These epigenetic modifications result in permanent cellular transformations without altering the underlying DNA nucleotide sequence. This review summarizes the major concepts in the field of epigenetics with a focus on the effects of low-LET LDIR ( |
| doi_str_mv | 10.1667/RR14587.1 |
| format | Article |
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This review summarizes the major concepts in the field of epigenetics with a focus on the effects of low-LET LDIR (<100 mGy) and oxidative stress on epigenetic gene modification. In this review, we show evidence that suggests that LDIR-induced oxidative stress provides a mechanistic link between LDIR and epigenetic gene regulation. We also discuss the potential implication of LDIR exposure during pregnancy where intrauterine fetal development is highly susceptible to oxidative stress-induced epigenetic programing.</description><identifier>ISSN: 0033-7587</identifier><identifier>EISSN: 1938-5404</identifier><identifier>DOI: 10.1667/RR14587.1</identifier><identifier>PMID: 28753061</identifier><language>eng</language><publisher>United States: The Radiation Research Society</publisher><subject>Animals ; Dose-Response Relationship, Radiation ; Epigenesis, Genetic - radiation effects ; Health ; Humans ; Oxidative Stress - radiation effects ; Radiation Injuries - genetics ; Radiation Injuries - metabolism ; REVIEW ; REVIEWS ; Space life sciences</subject><ispartof>Radiation research, 2017-10, Vol.188 (4.2), p.525-538</ispartof><rights>2017 by Radiation Research Society</rights><rights>Copyright © 2017 Radiation Research Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b445t-70759b683c790621a4e163ec5cd2ecfcc64887d0ccbb654e2516f76c673509713</citedby><cites>FETCH-LOGICAL-b445t-70759b683c790621a4e163ec5cd2ecfcc64887d0ccbb654e2516f76c673509713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/26428306$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/26428306$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28753061$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tharmalingam, Sujeenthar</creatorcontrib><creatorcontrib>Sreetharan, Shayenthiran</creatorcontrib><creatorcontrib>Kulesza, Adomas V.</creatorcontrib><creatorcontrib>Boreham, Douglas R.</creatorcontrib><creatorcontrib>Tai, T. C.</creatorcontrib><title>Low-Dose Ionizing Radiation Exposure, Oxidative Stress and Epigenetic Programing of Health and Disease</title><title>Radiation research</title><addtitle>Radiat Res</addtitle><description>Ionizing radiation exposure from medical diagnostic imaging has greatly increased over the last few decades. Approximately 80% of patients who undergo medical imaging are exposed to low-dose ionizing radiation (LDIR). Although there is widespread consensus regarding the harmful effects of high doses of radiation, the biological effects of low-linear energy transfer (LET) LDIR is not well understood. LDIR is known to promote oxidative stress, however, these levels may not be large enough to result in genomic mutations. There is emerging evidence that oxidative stress causes heritable modifications via epigenetic mechanisms (DNA methylation, histone modification, noncoding RNA regulation). These epigenetic modifications result in permanent cellular transformations without altering the underlying DNA nucleotide sequence. This review summarizes the major concepts in the field of epigenetics with a focus on the effects of low-LET LDIR (<100 mGy) and oxidative stress on epigenetic gene modification. In this review, we show evidence that suggests that LDIR-induced oxidative stress provides a mechanistic link between LDIR and epigenetic gene regulation. We also discuss the potential implication of LDIR exposure during pregnancy where intrauterine fetal development is highly susceptible to oxidative stress-induced epigenetic programing.</description><subject>Animals</subject><subject>Dose-Response Relationship, Radiation</subject><subject>Epigenesis, Genetic - radiation effects</subject><subject>Health</subject><subject>Humans</subject><subject>Oxidative Stress - radiation effects</subject><subject>Radiation Injuries - genetics</subject><subject>Radiation Injuries - metabolism</subject><subject>REVIEW</subject><subject>REVIEWS</subject><subject>Space life sciences</subject><issn>0033-7587</issn><issn>1938-5404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF1PwjAUhhujEUQv_AGa3qmJw3brx3ZpAIWEBIN6vXTdGZbAiu2m6K93COqdV83p85z3JC9Cp5R0qRDyZjqljMeyS_dQmyZRHHBG2D5qExJFgWxICx15PyfNTEVyiFphLHlEBG2jYmzfg771gEe2NJ-mnOGpyo2qjC3xYL2yvnZwjSdrkzd_b4AfKwfeY1XmeLAyMyihMho_ODtzarlZtwUeglpUL99O33hQHo7RQaEWHk52bwc93w2eesNgPLkf9W7HQcYYrwJJJE8yEUdaJkSEVDGgIgLNdR6CLrQWLI5lTrTOMsEZhJyKQgotZMRJImnUQZfb3JWzrzX4Kl0ar2GxUCXY2qc0CRlPSJyIRr3aqtpZ7x0U6cqZpXIfKSXpptZ0V2u6iT3fxdbZEvJf86fHRjjbCnNfWffHBQvjRmj4xZZnxtoS_jn1BeXvh74</recordid><startdate>201710</startdate><enddate>201710</enddate><creator>Tharmalingam, Sujeenthar</creator><creator>Sreetharan, Shayenthiran</creator><creator>Kulesza, Adomas V.</creator><creator>Boreham, Douglas R.</creator><creator>Tai, T. 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| subjects | Animals Dose-Response Relationship, Radiation Epigenesis, Genetic - radiation effects Health Humans Oxidative Stress - radiation effects Radiation Injuries - genetics Radiation Injuries - metabolism REVIEW REVIEWS Space life sciences |
| title | Low-Dose Ionizing Radiation Exposure, Oxidative Stress and Epigenetic Programing of Health and Disease |
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