Electrophysiological Features of Single Store-Operated Calcium Channels in HEK S4 Cell Line with Stable STIM1 Protein Knockdown

An important role in intracellular calcium signaling is played by store-operated channels activated by STIM proteins, calcium sensors of the endoplasmic reticulum. In stable STIM1 knockdown HEK S4 cells, single channels activated by depletion of intracellular calcium stores were detected by cell-att...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2017-07, Vol.163 (3), p.326-329
Hauptverfasser:	Shalygin, A. V., Vigont, V. A., Glushankova, L. N., Zimina, O. A., Kolesnikov, D. O., Skopin, A. Yu, Kaznacheeva, E. V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical and Life Sciences Biomedicine Calcium (intracellular) Calcium (reticular) Calcium - metabolism Calcium channels Calcium channels (voltage-gated) Calcium Channels - genetics Calcium Channels - metabolism Calcium Signaling Calcium signalling Cell Biology Cell lines Clone Cells Endoplasmic reticulum Endoplasmic Reticulum - drug effects Endoplasmic Reticulum - physiology Enzyme Inhibitors - pharmacology Gene Expression Regulation HEK293 Cells Humans Internal Medicine Intracellular Intracellular signalling Ion Transport - drug effects Laboratory Medicine Membrane Potentials - drug effects Neoplasm Proteins - deficiency Neoplasm Proteins - genetics Patch-Clamp Techniques Pathology STIM1 protein Stromal Interaction Molecule 1 - deficiency Stromal Interaction Molecule 1 - genetics Thapsigargin - pharmacology Uridine Triphosphate - pharmacology
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