Lipoxygenase Inhibitors Nordihydroguaiaretic Acid and Fungus Lecanicillum lecanii Extract Induce Death of Lymphoid Leukemia Cells
We studied the effect of lipoxygenase inhibitors nordihydroguaiaretic acid (NDGA) and fungus Lecanicillum lecanii extract on lymphatic leukemia P388 cells. The cells grown in the abdominal cavity of DBA2 mice for 7 days were transferred into a nutrient medium. The effect of lipoxygenase inhibitors w...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2017-07, Vol.163 (3), p.330-333 |
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| creator | Bibikova, M. V. Spiridonova, N. A. Korystova, A. F. Kublik, L. N. Levitman, M. Kh Shaposhnikova, V. V. Korystov, Yu. N. |
| description | We studied the effect of lipoxygenase inhibitors nordihydroguaiaretic acid (NDGA) and fungus
Lecanicillum lecanii
extract on lymphatic leukemia P388 cells. The cells grown in the abdominal cavity of DBA2 mice for 7 days were transferred into a nutrient medium. The effect of lipoxygenase inhibitors was evaluated by changes in cell number, trypan blue staining, nucleus damage, and changes in cell distribution by DNA content after 22-h incubation. NDGA and fungus extract induced apoptotic death of lymphatic leukemia cells, which was seen from nucleus damage and reduced DNA content in cells. IC
50
for NDGA and fungus extract was 0.66 and 5.5 μg/ml, respectively. |
| doi_str_mv | 10.1007/s10517-017-3796-9 |
| format | Article |
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Lecanicillum lecanii
extract on lymphatic leukemia P388 cells. The cells grown in the abdominal cavity of DBA2 mice for 7 days were transferred into a nutrient medium. The effect of lipoxygenase inhibitors was evaluated by changes in cell number, trypan blue staining, nucleus damage, and changes in cell distribution by DNA content after 22-h incubation. NDGA and fungus extract induced apoptotic death of lymphatic leukemia cells, which was seen from nucleus damage and reduced DNA content in cells. IC
50
for NDGA and fungus extract was 0.66 and 5.5 μg/ml, respectively.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-017-3796-9</identifier><identifier>PMID: 28744653</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animals ; Antineoplastic Agents - pharmacology ; Apoptosis ; Apoptosis - drug effects ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Cell Nucleus - drug effects ; Cell Nucleus - metabolism ; Cell Nucleus - pathology ; Cell Nucleus - ultrastructure ; Cell number ; Complex Mixtures - pharmacology ; Cordyceps - chemistry ; Deoxyribonucleic acid ; DNA ; DNA damage ; DNA, Neoplasm - antagonists & inhibitors ; DNA, Neoplasm - biosynthesis ; Fungi ; Humans ; Inhibitory Concentration 50 ; Internal Medicine ; Laboratory Medicine ; Leukemia ; Lipoxygenase ; Lipoxygenase Inhibitors - pharmacology ; Lymphatic leukemia ; Lymphocytes - drug effects ; Lymphocytes - metabolism ; Lymphocytes - pathology ; Masoprocol - pharmacology ; Mice ; Mice, Inbred DBA ; Nordihydroguaiaretic acid ; Nuclei ; Pathology ; Rodents ; Tumor Cells, Cultured</subject><ispartof>Bulletin of experimental biology and medicine, 2017-07, Vol.163 (3), p.330-333</ispartof><rights>Springer Science+Business Media, LLC 2017</rights><rights>Bulletin of Experimental Biology and Medicine is a copyright of Springer, (2017). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-2355e5035f9e1d62b5771cfdf0bc9619259b374dae29becf0e8c54d1db9a41343</citedby><cites>FETCH-LOGICAL-c372t-2355e5035f9e1d62b5771cfdf0bc9619259b374dae29becf0e8c54d1db9a41343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10517-017-3796-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10517-017-3796-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28744653$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bibikova, M. V.</creatorcontrib><creatorcontrib>Spiridonova, N. A.</creatorcontrib><creatorcontrib>Korystova, A. F.</creatorcontrib><creatorcontrib>Kublik, L. N.</creatorcontrib><creatorcontrib>Levitman, M. Kh</creatorcontrib><creatorcontrib>Shaposhnikova, V. V.</creatorcontrib><creatorcontrib>Korystov, Yu. N.</creatorcontrib><title>Lipoxygenase Inhibitors Nordihydroguaiaretic Acid and Fungus Lecanicillum lecanii Extract Induce Death of Lymphoid Leukemia Cells</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><addtitle>Bull Exp Biol Med</addtitle><description>We studied the effect of lipoxygenase inhibitors nordihydroguaiaretic acid (NDGA) and fungus
Lecanicillum lecanii
extract on lymphatic leukemia P388 cells. The cells grown in the abdominal cavity of DBA2 mice for 7 days were transferred into a nutrient medium. The effect of lipoxygenase inhibitors was evaluated by changes in cell number, trypan blue staining, nucleus damage, and changes in cell distribution by DNA content after 22-h incubation. NDGA and fungus extract induced apoptotic death of lymphatic leukemia cells, which was seen from nucleus damage and reduced DNA content in cells. IC
50
for NDGA and fungus extract was 0.66 and 5.5 μg/ml, respectively.</description><subject>Animals</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Cell Nucleus - drug effects</subject><subject>Cell Nucleus - metabolism</subject><subject>Cell Nucleus - pathology</subject><subject>Cell Nucleus - ultrastructure</subject><subject>Cell number</subject><subject>Complex Mixtures - pharmacology</subject><subject>Cordyceps - chemistry</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA damage</subject><subject>DNA, Neoplasm - antagonists & inhibitors</subject><subject>DNA, Neoplasm - biosynthesis</subject><subject>Fungi</subject><subject>Humans</subject><subject>Inhibitory Concentration 50</subject><subject>Internal Medicine</subject><subject>Laboratory Medicine</subject><subject>Leukemia</subject><subject>Lipoxygenase</subject><subject>Lipoxygenase Inhibitors - pharmacology</subject><subject>Lymphatic leukemia</subject><subject>Lymphocytes - drug effects</subject><subject>Lymphocytes - metabolism</subject><subject>Lymphocytes - pathology</subject><subject>Masoprocol - pharmacology</subject><subject>Mice</subject><subject>Mice, Inbred DBA</subject><subject>Nordihydroguaiaretic acid</subject><subject>Nuclei</subject><subject>Pathology</subject><subject>Rodents</subject><subject>Tumor Cells, Cultured</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kU1v1DAQhi1ERZeFH8AFWeLCJeCPOI6P1dKWShG9tGfLsSe7Lkm82LHUPfLP8XYLSEgcLGvkZx6P5kXoHSWfKCHyc6JEUFmRcrhUTaVeoBUVklctY_QlWpECVXXbtufodUoPx5I09BU6Z62s60bwFfrZ-X14PGxhNgnwzbzzvV9CTPhbiM7vDi6GbTbeRFi8xRfWO2xmh6_yvM0Jd2DN7K0fxzzh8anw-PJxicYuReayBfwFzLLDYcDdYdrvQhF0kL_D5A3ewDimN-hsMGOCt8_3Gt1fXd5tvlbd7fXN5qKrLJdsqRgXAgThYlBAXcN6ISW1gxtIb1VDFROq57J2BpjqwQ4EWitqR12vTE15zdfo48m7j-FHhrToySdbJjAzhJx0UZT-upWqoB_-QR9CjnOZTrOyQ9U0vCxvjeiJsjGkFGHQ--gnEw-aEn3MR5_y0SUffcxHH83vn825n8D96fgdSAHYCUjlad5C_Pv1_62_AIImnF8</recordid><startdate>20170701</startdate><enddate>20170701</enddate><creator>Bibikova, M. 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V.</au><au>Spiridonova, N. A.</au><au>Korystova, A. F.</au><au>Kublik, L. N.</au><au>Levitman, M. Kh</au><au>Shaposhnikova, V. V.</au><au>Korystov, Yu. N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lipoxygenase Inhibitors Nordihydroguaiaretic Acid and Fungus Lecanicillum lecanii Extract Induce Death of Lymphoid Leukemia Cells</atitle><jtitle>Bulletin of experimental biology and medicine</jtitle><stitle>Bull Exp Biol Med</stitle><addtitle>Bull Exp Biol Med</addtitle><date>2017-07-01</date><risdate>2017</risdate><volume>163</volume><issue>3</issue><spage>330</spage><epage>333</epage><pages>330-333</pages><issn>0007-4888</issn><eissn>1573-8221</eissn><abstract>We studied the effect of lipoxygenase inhibitors nordihydroguaiaretic acid (NDGA) and fungus
Lecanicillum lecanii
extract on lymphatic leukemia P388 cells. The cells grown in the abdominal cavity of DBA2 mice for 7 days were transferred into a nutrient medium. The effect of lipoxygenase inhibitors was evaluated by changes in cell number, trypan blue staining, nucleus damage, and changes in cell distribution by DNA content after 22-h incubation. NDGA and fungus extract induced apoptotic death of lymphatic leukemia cells, which was seen from nucleus damage and reduced DNA content in cells. IC
50
for NDGA and fungus extract was 0.66 and 5.5 μg/ml, respectively.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>28744653</pmid><doi>10.1007/s10517-017-3796-9</doi><tpages>4</tpages></addata></record> |
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| subjects | Animals Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Biomedical and Life Sciences Biomedicine Cell Biology Cell Nucleus - drug effects Cell Nucleus - metabolism Cell Nucleus - pathology Cell Nucleus - ultrastructure Cell number Complex Mixtures - pharmacology Cordyceps - chemistry Deoxyribonucleic acid DNA DNA damage DNA, Neoplasm - antagonists & inhibitors DNA, Neoplasm - biosynthesis Fungi Humans Inhibitory Concentration 50 Internal Medicine Laboratory Medicine Leukemia Lipoxygenase Lipoxygenase Inhibitors - pharmacology Lymphatic leukemia Lymphocytes - drug effects Lymphocytes - metabolism Lymphocytes - pathology Masoprocol - pharmacology Mice Mice, Inbred DBA Nordihydroguaiaretic acid Nuclei Pathology Rodents Tumor Cells, Cultured |
| title | Lipoxygenase Inhibitors Nordihydroguaiaretic Acid and Fungus Lecanicillum lecanii Extract Induce Death of Lymphoid Leukemia Cells |
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