Expression of 3β-Hydroxysteroid Dehydrogenase Type 1 in Breast Cancer is Associated with Poor Prognosis Independent of Estrogen Receptor Status

Background Human 3β-hydroxysteroid dehydrogenase type 1 (HSD3B1) plays a vital role in steroidogenesis in breast tumors and may therefore be a suitable target for treatment of breast cancer. This study investigated the role of HSD3B1 in the pathogenesis of breast cancer in clinical and experimental...

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Veröffentlicht in:	Annals of surgical oncology 2017-12, Vol.24 (13), p.4033-4041
Hauptverfasser:	Chang, Yuan-Ching, Chen, Chi-Kuan, Chen, Ming-Jen, Lin, Jiunn-Chang, Lin, Chi-Hsin, Huang, Wen-Chien, Cheng, Shih-Ping, Chen, Shan-Na, Liu, Chien-Liang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers, Tumor - metabolism Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Carcinoma, Intraductal, Noninfiltrating - genetics Carcinoma, Intraductal, Noninfiltrating - metabolism Carcinoma, Intraductal, Noninfiltrating - pathology Cell Cycle Cell Movement Cell Proliferation Dehydrogenases Dihydrotestosterone - analogs & derivatives Dihydrotestosterone - pharmacology Estrogens Female Follow-Up Studies Humans Immunohistochemistry Medical prognosis Medicine Medicine & Public Health Mice Mice, Inbred BALB C Mice, Nude Middle Aged Multienzyme Complexes - antagonists & inhibitors Multienzyme Complexes - genetics Multienzyme Complexes - metabolism Oncology Progesterone Reductase - antagonists & inhibitors Progesterone Reductase - genetics Progesterone Reductase - metabolism Prognosis Receptors, Estrogen - metabolism RNA, Small Interfering - genetics Steroid Isomerases - antagonists & inhibitors Steroid Isomerases - genetics Steroid Isomerases - metabolism Steroidogenesis Surgery Surgical Oncology Survival Rate Translational Research and Biomarkers Tumor cell lines Tumor Cells, Cultured Tumors Xenograft Model Antitumor Assays Xenografts
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