Anti-Inflammatory Effects of Stearidonic Acid Mediated by Suppression of NF-κB and MAP-Kinase Pathways in Macrophages
Stearidonic acid (SDA, 18:4n-3) is an omega-3 polyunsaturated fatty acid present in oils derived from plants of the Boraginaceae family. In this study, we determined the anti-inflammatory effects of SDA isolated from echium oil on lipopolysaccharide (LPS)-induced inflammatory responses in RAW 264.7...
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| Veröffentlicht in: | Lipids 2017-09, Vol.52 (9), p.781-787 |
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| creator | Sung, Jeehye Jeon, Heemang Kim, In-Hwan Jeong, Heon Sang Lee, Junsoo |
| description | Stearidonic acid (SDA, 18:4n-3) is an omega-3 polyunsaturated fatty acid present in oils derived from plants of the Boraginaceae family. In this study, we determined the anti-inflammatory effects of SDA isolated from echium oil on lipopolysaccharide (LPS)-induced inflammatory responses in RAW 264.7 macrophages. SDA significantly downregulated the levels of the inducible nitric oxide synthase (iNOS) protein, thereby suppressing the production of nitric oxide (NO) in LPS-stimulated RAW 264.7 cells. In addition, SDA inhibited the nuclear translocation and promoter activity of nuclear factor κB (NFκB) and the phosphorylation of mitogen-activated protein kinases (MAPK) such as extracellular signal regulated kinase 1/2, c-jun N terminal kinase, and p38 in LPS-stimulated RAW 264.7 cells. Our results showed that SDA exerted anti-inflammatory effects by suppressing iNOS-mediated NO production via inactivation of NFκB and MAPK signaling pathways. |
| doi_str_mv | 10.1007/s11745-017-4278-6 |
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In this study, we determined the anti-inflammatory effects of SDA isolated from echium oil on lipopolysaccharide (LPS)-induced inflammatory responses in RAW 264.7 macrophages. SDA significantly downregulated the levels of the inducible nitric oxide synthase (iNOS) protein, thereby suppressing the production of nitric oxide (NO) in LPS-stimulated RAW 264.7 cells. In addition, SDA inhibited the nuclear translocation and promoter activity of nuclear factor κB (NFκB) and the phosphorylation of mitogen-activated protein kinases (MAPK) such as extracellular signal regulated kinase 1/2, c-jun N terminal kinase, and p38 in LPS-stimulated RAW 264.7 cells. Our results showed that SDA exerted anti-inflammatory effects by suppressing iNOS-mediated NO production via inactivation of NFκB and MAPK signaling pathways.</description><identifier>ISSN: 0024-4201</identifier><identifier>EISSN: 1558-9307</identifier><identifier>DOI: 10.1007/s11745-017-4278-6</identifier><identifier>PMID: 28744771</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Animals ; Anti-Inflammatory Agents - chemistry ; Anti-Inflammatory Agents - pharmacology ; Anti‐inflammatory ; Biomedical and Life Sciences ; Boraginaceae - chemistry ; Communication ; Echium oil ; Fatty Acids, Omega-3 - chemistry ; Fatty Acids, Omega-3 - pharmacology ; Life Sciences ; Lipidology ; Lipopolysaccharides - immunology ; Macrophages - drug effects ; Macrophages - immunology ; MAPK (mitogen‐activated protein kinases) pathway ; Medical Biochemistry ; Medicinal Chemistry ; Mice ; Microbial Genetics and Genomics ; Mitogen-Activated Protein Kinases - immunology ; Neurochemistry ; NF-kappa B - immunology ; NFκB (nuclear factor κB) ; Nitric Oxide Synthase Type II - immunology ; Nutrition ; Plant Oils - chemistry ; RAW 264.7 Cells ; Signal Transduction - drug effects ; Stearidonic acid</subject><ispartof>Lipids, 2017-09, Vol.52 (9), p.781-787</ispartof><rights>AOCS 2017</rights><rights>2017 American Oil Chemists' Society (AOCS)</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3921-91d40058a6a1bef17de62e82ef1da955be08923b6ec0606c844a63140bb87f493</citedby><cites>FETCH-LOGICAL-c3921-91d40058a6a1bef17de62e82ef1da955be08923b6ec0606c844a63140bb87f493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11745-017-4278-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11745-017-4278-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,41464,42533,45550,45551,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28744771$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sung, Jeehye</creatorcontrib><creatorcontrib>Jeon, Heemang</creatorcontrib><creatorcontrib>Kim, In-Hwan</creatorcontrib><creatorcontrib>Jeong, Heon Sang</creatorcontrib><creatorcontrib>Lee, Junsoo</creatorcontrib><title>Anti-Inflammatory Effects of Stearidonic Acid Mediated by Suppression of NF-κB and MAP-Kinase Pathways in Macrophages</title><title>Lipids</title><addtitle>Lipids</addtitle><addtitle>Lipids</addtitle><description>Stearidonic acid (SDA, 18:4n-3) is an omega-3 polyunsaturated fatty acid present in oils derived from plants of the Boraginaceae family. In this study, we determined the anti-inflammatory effects of SDA isolated from echium oil on lipopolysaccharide (LPS)-induced inflammatory responses in RAW 264.7 macrophages. SDA significantly downregulated the levels of the inducible nitric oxide synthase (iNOS) protein, thereby suppressing the production of nitric oxide (NO) in LPS-stimulated RAW 264.7 cells. In addition, SDA inhibited the nuclear translocation and promoter activity of nuclear factor κB (NFκB) and the phosphorylation of mitogen-activated protein kinases (MAPK) such as extracellular signal regulated kinase 1/2, c-jun N terminal kinase, and p38 in LPS-stimulated RAW 264.7 cells. Our results showed that SDA exerted anti-inflammatory effects by suppressing iNOS-mediated NO production via inactivation of NFκB and MAPK signaling pathways.</description><subject>Animals</subject><subject>Anti-Inflammatory Agents - chemistry</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Anti‐inflammatory</subject><subject>Biomedical and Life Sciences</subject><subject>Boraginaceae - chemistry</subject><subject>Communication</subject><subject>Echium oil</subject><subject>Fatty Acids, Omega-3 - chemistry</subject><subject>Fatty Acids, Omega-3 - pharmacology</subject><subject>Life Sciences</subject><subject>Lipidology</subject><subject>Lipopolysaccharides - immunology</subject><subject>Macrophages - drug effects</subject><subject>Macrophages - immunology</subject><subject>MAPK (mitogen‐activated protein kinases) pathway</subject><subject>Medical Biochemistry</subject><subject>Medicinal Chemistry</subject><subject>Mice</subject><subject>Microbial Genetics and Genomics</subject><subject>Mitogen-Activated Protein Kinases - immunology</subject><subject>Neurochemistry</subject><subject>NF-kappa B - immunology</subject><subject>NFκB (nuclear factor κB)</subject><subject>Nitric Oxide Synthase Type II - immunology</subject><subject>Nutrition</subject><subject>Plant Oils - chemistry</subject><subject>RAW 264.7 Cells</subject><subject>Signal Transduction - drug effects</subject><subject>Stearidonic acid</subject><issn>0024-4201</issn><issn>1558-9307</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEFu1DAUQC0EotPCAdggL9kY_B0ndpZDaWHEFEYqrC0n-WldJU6wE6pcjUP0THiUwhJWtuX3vr4eIa-AvwXO1bsIoGTOOCgmhdKseEI2kOealRlXT8mGcyHTD4cTchrjXXqCLPPn5ERoJaVSsCE_t35ybOfbzva9nYaw0Iu2xXqKdGjp9YQ2uGbwrqbb2jX0ChtnJ2xotdDreRwDxugGf2S_XLKHX--p9YnaHthn521EerDT7b1dInWeXtk6DOOtvcH4gjxrbRfx5eN5Rr5fXnw7_8T2Xz_uzrd7VmelAFZCIznPtS0sVNiCarAQqEW6NrbM8wq5LkVWFVjzghe1ltIWGUheVVq1sszOyJt17hiGHzPGyfQu1th11uMwRwPJVlLoLE8orGhaMsaArRmD621YDHBzzG3W3CblNsfcpkjO68fxc9Vj89f40zcBagXuXYfL_yea_e7wgSt9NMVqxiT5GwzmbpiDT7H-sc9v19SbOg</recordid><startdate>201709</startdate><enddate>201709</enddate><creator>Sung, Jeehye</creator><creator>Jeon, Heemang</creator><creator>Kim, In-Hwan</creator><creator>Jeong, Heon Sang</creator><creator>Lee, Junsoo</creator><general>Springer Berlin Heidelberg</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201709</creationdate><title>Anti-Inflammatory Effects of Stearidonic Acid Mediated by Suppression of NF-κB and MAP-Kinase Pathways in Macrophages</title><author>Sung, Jeehye ; Jeon, Heemang ; Kim, In-Hwan ; Jeong, Heon Sang ; Lee, Junsoo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3921-91d40058a6a1bef17de62e82ef1da955be08923b6ec0606c844a63140bb87f493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Anti-Inflammatory Agents - chemistry</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Anti‐inflammatory</topic><topic>Biomedical and Life Sciences</topic><topic>Boraginaceae - chemistry</topic><topic>Communication</topic><topic>Echium oil</topic><topic>Fatty Acids, Omega-3 - chemistry</topic><topic>Fatty Acids, Omega-3 - pharmacology</topic><topic>Life Sciences</topic><topic>Lipidology</topic><topic>Lipopolysaccharides - immunology</topic><topic>Macrophages - drug effects</topic><topic>Macrophages - immunology</topic><topic>MAPK (mitogen‐activated protein kinases) pathway</topic><topic>Medical Biochemistry</topic><topic>Medicinal Chemistry</topic><topic>Mice</topic><topic>Microbial Genetics and Genomics</topic><topic>Mitogen-Activated Protein Kinases - immunology</topic><topic>Neurochemistry</topic><topic>NF-kappa B - immunology</topic><topic>NFκB (nuclear factor κB)</topic><topic>Nitric Oxide Synthase Type II - immunology</topic><topic>Nutrition</topic><topic>Plant Oils - chemistry</topic><topic>RAW 264.7 Cells</topic><topic>Signal Transduction - drug effects</topic><topic>Stearidonic acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sung, Jeehye</creatorcontrib><creatorcontrib>Jeon, Heemang</creatorcontrib><creatorcontrib>Kim, In-Hwan</creatorcontrib><creatorcontrib>Jeong, Heon Sang</creatorcontrib><creatorcontrib>Lee, Junsoo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Lipids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sung, Jeehye</au><au>Jeon, Heemang</au><au>Kim, In-Hwan</au><au>Jeong, Heon Sang</au><au>Lee, Junsoo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-Inflammatory Effects of Stearidonic Acid Mediated by Suppression of NF-κB and MAP-Kinase Pathways in Macrophages</atitle><jtitle>Lipids</jtitle><stitle>Lipids</stitle><addtitle>Lipids</addtitle><date>2017-09</date><risdate>2017</risdate><volume>52</volume><issue>9</issue><spage>781</spage><epage>787</epage><pages>781-787</pages><issn>0024-4201</issn><eissn>1558-9307</eissn><abstract>Stearidonic acid (SDA, 18:4n-3) is an omega-3 polyunsaturated fatty acid present in oils derived from plants of the Boraginaceae family. In this study, we determined the anti-inflammatory effects of SDA isolated from echium oil on lipopolysaccharide (LPS)-induced inflammatory responses in RAW 264.7 macrophages. SDA significantly downregulated the levels of the inducible nitric oxide synthase (iNOS) protein, thereby suppressing the production of nitric oxide (NO) in LPS-stimulated RAW 264.7 cells. In addition, SDA inhibited the nuclear translocation and promoter activity of nuclear factor κB (NFκB) and the phosphorylation of mitogen-activated protein kinases (MAPK) such as extracellular signal regulated kinase 1/2, c-jun N terminal kinase, and p38 in LPS-stimulated RAW 264.7 cells. Our results showed that SDA exerted anti-inflammatory effects by suppressing iNOS-mediated NO production via inactivation of NFκB and MAPK signaling pathways.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>28744771</pmid><doi>10.1007/s11745-017-4278-6</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - pharmacology Anti‐inflammatory Biomedical and Life Sciences Boraginaceae - chemistry Communication Echium oil Fatty Acids, Omega-3 - chemistry Fatty Acids, Omega-3 - pharmacology Life Sciences Lipidology Lipopolysaccharides - immunology Macrophages - drug effects Macrophages - immunology MAPK (mitogen‐activated protein kinases) pathway Medical Biochemistry Medicinal Chemistry Mice Microbial Genetics and Genomics Mitogen-Activated Protein Kinases - immunology Neurochemistry NF-kappa B - immunology NFκB (nuclear factor κB) Nitric Oxide Synthase Type II - immunology Nutrition Plant Oils - chemistry RAW 264.7 Cells Signal Transduction - drug effects Stearidonic acid |
| title | Anti-Inflammatory Effects of Stearidonic Acid Mediated by Suppression of NF-κB and MAP-Kinase Pathways in Macrophages |
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