In vivo efficacy of β-lactam/tripropeptin C in a mouse septicemia model and the mechanism of reverse β-lactam resistance in methicillin-resistant Staphylococcus aureus mediated by tripropeptin C

Natural lipopeptide antibiotic tripropeptin C (TPPC) revitalizes and synergistically potentiates the activities of the class of β-lactam antibiotics against methicillin-resistant Staphylococcus aureus (MRSA) but not against methicillin-sensitive S. aureus in vitro ; however, the mode of action remai...

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Veröffentlicht in:	Journal of antibiotics 2018-01, Vol.71 (1), p.79-85
Hauptverfasser:	Hashizume, Hideki, Takahashi, Yoshiaki, Masuda, Tohru, Ohba, Shun-ichi, Ohishi, Tomokazu, Kawada, Manabu, Igarashi, Masayuki
Format:	Artikel
Sprache:	eng
Schlagworte:	45/22 45/23 45/44 631/154 64/60 Amides Antibiotics Bacteriology Biomedical and Life Sciences Bioorganic Chemistry Cefotiam Ceftizoxime Drug resistance Effectiveness Gene expression Genes Life Sciences MecA protein Medicinal Chemistry Methicillin Microbiology Mode of action Organic Chemistry original-article Penicillin Penicillin-binding protein Polymerase chain reaction Sepsis Septicemia Staphylococcus aureus Staphylococcus infections β Lactamase β-Lactam antibiotics
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