Exercise-induced improvement in endothelial dysfunction is not mediated by changes in CV risk factors: pooled analysis of diverse patient populations

1 School of Human Movement and Exercise Science, The University of Western Australia; and 2 Department of Cardiology and 3 Cardiac Transplant Unit, Royal Perth Hospital, Western Australia, West Australian Institute for Medical Research, Crawley, Western Australia 6009 Submitted 16 June 2003 ; accepted in final form 18 August 2003 We have pooled data from a series of our exercise training studies undertaken in groups with a broad range of vascular (dys) function to the examine the hypothesis that exercise-induced improvements in the conduit and/or resistance vessel function are related to improvements in risk factors for cardiovascular (CV) disease. Endothelium-dependent and -independent conduit vessel function were assessed by using wall tracking of high-resolution ultrasound images of the brachial artery response to flow-mediated dilation (FMD) and glyceryl trinitrate. Resistance vessel function was assessed using intrabrachial administration of acetylcholine (ACh), sodium nitroprusside, and N G -monomethyl- L -arginine. Randomized cross-over studies of 8-wk exercise training were undertaken in untreated hypercholesterolemic ( n = 11), treated hypercholesterolemic ( n = 11), coronary artery disease ( n = 10), chronic heart failure ( n = 12), Type 2 diabetic ( n = 15), and healthy control subjects ( n = 16). Exercise training did not significantly alter plasma lipids, blood pressure, blood glucose, waist-to-hip ratio, or body mass index values, despite significant improvement in both FMD and ACh responses. There were no correlations between changes in any risk factor variables and indexes of either resistance or conduit vessel function. We conclude that, in these subjects with antecedent vascular dysfunction, the beneficial effects of relatively short-term exercise training on vascular function are not solely mediated by the effects of exercise on CV risk factors. acetylcholine; flow-mediated dilation; resistance vessel; conduit artery; cardiovascular Address for reprint requests and other correspondence: D. Green, School of Human Movement and Exercise Science, The Univ. of Western Australia, Crawley, Western Australia 6009.