Survival and prognostic factors at time of diagnosis in high-grade appendicular osteosarcoma: a 21 year single institution evaluation from east Denmark
Survival of patients with high-grade osteosarcoma (HOS), the most common primary bone cancer, has not improved significantly the last 30 years and the disease remains a major challenge. The purpose of this study is to evaluate survival in relation to prognostic factors at time of diagnosis among pat...
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| Veröffentlicht in: | Acta oncologica 2018-03, Vol.57 (3), p.420-425 |
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| container_title | Acta oncologica |
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| creator | Colding-Rasmussen, Thomas Thorn, Andrea Pohly Horstmann, Peter Rechnitzer, Catherine Hjalgrim, Lisa Lyngsie Krarup-Hansen, Anders Petersen, Michael Mørk |
| description | Survival of patients with high-grade osteosarcoma (HOS), the most common primary bone cancer, has not improved significantly the last 30 years and the disease remains a major challenge. The purpose of this study is to evaluate survival in relation to prognostic factors at time of diagnosis among patients diagnosed with primary appendicular HOS in East Denmark between 1990 and 2010.
101 patients (median age = 20 years, female/male ratio = 56/45) diagnosed with primary appendicular high-grade osteosarcoma between 1990 and 2010 were included in this study. Initially, 156 patients diagnosed with osteosarcoma between 1990 and 2010 were identified through the population based Regional Database of Pathology, which covers a population of approximately 2.7 million (east Denmark). 55 patients were excluded due to (A) tumor was low grade (n = 22), (B) located in axial skeleton (n = 18), (C) incorrect diagnosis (n = 11) or (D) biopsy represented a tumor relapse from a former primary osteosarcoma (n = 4). Overall survival was evaluated using the Kaplan-Meier survival analysis and log-rank test. Prognostic factors were analyzed using uni- and multivariate cox-regression method with variables scored equally in the model. p Values |
| doi_str_mv | 10.1080/0284186x.2017.1351620 |
| format | Article |
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101 patients (median age = 20 years, female/male ratio = 56/45) diagnosed with primary appendicular high-grade osteosarcoma between 1990 and 2010 were included in this study. Initially, 156 patients diagnosed with osteosarcoma between 1990 and 2010 were identified through the population based Regional Database of Pathology, which covers a population of approximately 2.7 million (east Denmark). 55 patients were excluded due to (A) tumor was low grade (n = 22), (B) located in axial skeleton (n = 18), (C) incorrect diagnosis (n = 11) or (D) biopsy represented a tumor relapse from a former primary osteosarcoma (n = 4). Overall survival was evaluated using the Kaplan-Meier survival analysis and log-rank test. Prognostic factors were analyzed using uni- and multivariate cox-regression method with variables scored equally in the model. p Values <.05 were considered statistically significant.
The probability of 5- and 10-year survival was 51% (95% CI: 41-61) and 46% (95% CI: 36-56), respectively. Metastatic stage at diagnosis and tumor size ≥10 cm measured radiologically at the largest diameter were independent prognostic factors for decreased survival with significant increased hazard-risks of 3.5 (95% CI: 1.9-6.5) and 1.97 (95% CI: 1.1-3.6), respectively.
In this single institution evaluation of primary appendicular HOS we found 5-and 10-year survival rates consistent with international standards for this patient group. Distant metastases and tumor size ≥10 cm at the time of diagnosis were independent prognostic factors for decreased survival in our cohort. These results underline the importance of awareness and early referral from the primary sector.</description><identifier>ISSN: 0284-186X</identifier><identifier>EISSN: 1651-226X</identifier><identifier>DOI: 10.1080/0284186x.2017.1351620</identifier><identifier>PMID: 28741397</identifier><language>eng</language><publisher>England</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Bone Neoplasms - mortality ; Bone Neoplasms - pathology ; Child ; Denmark - epidemiology ; Female ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Osteosarcoma - mortality ; Osteosarcoma - pathology ; Prognosis ; Proportional Hazards Models ; Young Adult</subject><ispartof>Acta oncologica, 2018-03, Vol.57 (3), p.420-425</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-c8dcb39730fce82e8895dc15a1e00dedfa5b664450c62cda03491918b0c71933</citedby><cites>FETCH-LOGICAL-c422t-c8dcb39730fce82e8895dc15a1e00dedfa5b664450c62cda03491918b0c71933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28741397$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Colding-Rasmussen, Thomas</creatorcontrib><creatorcontrib>Thorn, Andrea Pohly</creatorcontrib><creatorcontrib>Horstmann, Peter</creatorcontrib><creatorcontrib>Rechnitzer, Catherine</creatorcontrib><creatorcontrib>Hjalgrim, Lisa Lyngsie</creatorcontrib><creatorcontrib>Krarup-Hansen, Anders</creatorcontrib><creatorcontrib>Petersen, Michael Mørk</creatorcontrib><title>Survival and prognostic factors at time of diagnosis in high-grade appendicular osteosarcoma: a 21 year single institution evaluation from east Denmark</title><title>Acta oncologica</title><addtitle>Acta Oncol</addtitle><description>Survival of patients with high-grade osteosarcoma (HOS), the most common primary bone cancer, has not improved significantly the last 30 years and the disease remains a major challenge. The purpose of this study is to evaluate survival in relation to prognostic factors at time of diagnosis among patients diagnosed with primary appendicular HOS in East Denmark between 1990 and 2010.
101 patients (median age = 20 years, female/male ratio = 56/45) diagnosed with primary appendicular high-grade osteosarcoma between 1990 and 2010 were included in this study. Initially, 156 patients diagnosed with osteosarcoma between 1990 and 2010 were identified through the population based Regional Database of Pathology, which covers a population of approximately 2.7 million (east Denmark). 55 patients were excluded due to (A) tumor was low grade (n = 22), (B) located in axial skeleton (n = 18), (C) incorrect diagnosis (n = 11) or (D) biopsy represented a tumor relapse from a former primary osteosarcoma (n = 4). Overall survival was evaluated using the Kaplan-Meier survival analysis and log-rank test. Prognostic factors were analyzed using uni- and multivariate cox-regression method with variables scored equally in the model. p Values <.05 were considered statistically significant.
The probability of 5- and 10-year survival was 51% (95% CI: 41-61) and 46% (95% CI: 36-56), respectively. Metastatic stage at diagnosis and tumor size ≥10 cm measured radiologically at the largest diameter were independent prognostic factors for decreased survival with significant increased hazard-risks of 3.5 (95% CI: 1.9-6.5) and 1.97 (95% CI: 1.1-3.6), respectively.
In this single institution evaluation of primary appendicular HOS we found 5-and 10-year survival rates consistent with international standards for this patient group. Distant metastases and tumor size ≥10 cm at the time of diagnosis were independent prognostic factors for decreased survival in our cohort. These results underline the importance of awareness and early referral from the primary sector.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Bone Neoplasms - mortality</subject><subject>Bone Neoplasms - pathology</subject><subject>Child</subject><subject>Denmark - epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Osteosarcoma - mortality</subject><subject>Osteosarcoma - pathology</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Young Adult</subject><issn>0284-186X</issn><issn>1651-226X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kU1v1DAQhi0EokvhJ4B85JLFY8eJw61q-ZIqcaCHvUWz9mTrksSL7azaX8LfxdtuOc1o5n3nQw9j70GsQRjxSUhTg2nu11JAuwaloZHiBVtBo6GSstm8ZKujpiqizRl7k9KdEEKqVr9mZ9K0NaiuXbG_v5Z48AccOc6O72PYzSFlb_mANoeYOGae_UQ8DNx5PHZ94n7mt353W-0iOuK439PsvF1GjLy4KSSMNkz4mSOXwB-o1JOfdyMVZ5mel-zDzKmsXfAxHWKYOGHK_IrmCePvt-zVgGOid6d4zm6-frm5_F5d__z24_LiurK1lLmyxtlteUSJwZKRZEynnQWNQEI4cgPqbdPUtRa2kdahUHUHHZitsC10Sp2zj09jy-d_Fkq5n3yyNI44U1hSD51UABo6U6T6SWpjSCnS0O-jL6c-9CD6I5L-hGTTH5H0JyTF9-G0YtlO5P67nhmofwyUilw</recordid><startdate>20180304</startdate><enddate>20180304</enddate><creator>Colding-Rasmussen, Thomas</creator><creator>Thorn, Andrea Pohly</creator><creator>Horstmann, Peter</creator><creator>Rechnitzer, Catherine</creator><creator>Hjalgrim, Lisa Lyngsie</creator><creator>Krarup-Hansen, Anders</creator><creator>Petersen, Michael Mørk</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20180304</creationdate><title>Survival and prognostic factors at time of diagnosis in high-grade appendicular osteosarcoma: a 21 year single institution evaluation from east Denmark</title><author>Colding-Rasmussen, Thomas ; Thorn, Andrea Pohly ; Horstmann, Peter ; Rechnitzer, Catherine ; Hjalgrim, Lisa Lyngsie ; Krarup-Hansen, Anders ; Petersen, Michael Mørk</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-c8dcb39730fce82e8895dc15a1e00dedfa5b664450c62cda03491918b0c71933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Bone Neoplasms - mortality</topic><topic>Bone Neoplasms - pathology</topic><topic>Child</topic><topic>Denmark - epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Osteosarcoma - mortality</topic><topic>Osteosarcoma - pathology</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Colding-Rasmussen, Thomas</creatorcontrib><creatorcontrib>Thorn, Andrea Pohly</creatorcontrib><creatorcontrib>Horstmann, Peter</creatorcontrib><creatorcontrib>Rechnitzer, Catherine</creatorcontrib><creatorcontrib>Hjalgrim, Lisa Lyngsie</creatorcontrib><creatorcontrib>Krarup-Hansen, Anders</creatorcontrib><creatorcontrib>Petersen, Michael Mørk</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta oncologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Colding-Rasmussen, Thomas</au><au>Thorn, Andrea Pohly</au><au>Horstmann, Peter</au><au>Rechnitzer, Catherine</au><au>Hjalgrim, Lisa Lyngsie</au><au>Krarup-Hansen, Anders</au><au>Petersen, Michael Mørk</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Survival and prognostic factors at time of diagnosis in high-grade appendicular osteosarcoma: a 21 year single institution evaluation from east Denmark</atitle><jtitle>Acta oncologica</jtitle><addtitle>Acta Oncol</addtitle><date>2018-03-04</date><risdate>2018</risdate><volume>57</volume><issue>3</issue><spage>420</spage><epage>425</epage><pages>420-425</pages><issn>0284-186X</issn><eissn>1651-226X</eissn><abstract>Survival of patients with high-grade osteosarcoma (HOS), the most common primary bone cancer, has not improved significantly the last 30 years and the disease remains a major challenge. The purpose of this study is to evaluate survival in relation to prognostic factors at time of diagnosis among patients diagnosed with primary appendicular HOS in East Denmark between 1990 and 2010.
101 patients (median age = 20 years, female/male ratio = 56/45) diagnosed with primary appendicular high-grade osteosarcoma between 1990 and 2010 were included in this study. Initially, 156 patients diagnosed with osteosarcoma between 1990 and 2010 were identified through the population based Regional Database of Pathology, which covers a population of approximately 2.7 million (east Denmark). 55 patients were excluded due to (A) tumor was low grade (n = 22), (B) located in axial skeleton (n = 18), (C) incorrect diagnosis (n = 11) or (D) biopsy represented a tumor relapse from a former primary osteosarcoma (n = 4). Overall survival was evaluated using the Kaplan-Meier survival analysis and log-rank test. Prognostic factors were analyzed using uni- and multivariate cox-regression method with variables scored equally in the model. p Values <.05 were considered statistically significant.
The probability of 5- and 10-year survival was 51% (95% CI: 41-61) and 46% (95% CI: 36-56), respectively. Metastatic stage at diagnosis and tumor size ≥10 cm measured radiologically at the largest diameter were independent prognostic factors for decreased survival with significant increased hazard-risks of 3.5 (95% CI: 1.9-6.5) and 1.97 (95% CI: 1.1-3.6), respectively.
In this single institution evaluation of primary appendicular HOS we found 5-and 10-year survival rates consistent with international standards for this patient group. Distant metastases and tumor size ≥10 cm at the time of diagnosis were independent prognostic factors for decreased survival in our cohort. These results underline the importance of awareness and early referral from the primary sector.</abstract><cop>England</cop><pmid>28741397</pmid><doi>10.1080/0284186x.2017.1351620</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Access via Taylor & Francis; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adolescent Adult Aged Aged, 80 and over Bone Neoplasms - mortality Bone Neoplasms - pathology Child Denmark - epidemiology Female Humans Kaplan-Meier Estimate Male Middle Aged Osteosarcoma - mortality Osteosarcoma - pathology Prognosis Proportional Hazards Models Young Adult |
| title | Survival and prognostic factors at time of diagnosis in high-grade appendicular osteosarcoma: a 21 year single institution evaluation from east Denmark |
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