Salidroside Ameliorates Diabetic Neuropathic Pain in Rats by Inhibiting Neuroinflammation

More than half of diabetic patients suffer from intractable neuropathic pain. As inflammation plays an important role in diabetic neuropathic pain, anti-inflammatory drugs might have therapeutic potentials for neuropathic pain. Salidroside (SAL), a phenylpropanoid glucoside, modulates a variety of c...

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Veröffentlicht in:	Journal of molecular neuroscience 2017-09, Vol.63 (1), p.9-16
Hauptverfasser:	Ni, Gui-Lian, Cui, Rong, Shao, Ai-Min, Wu, Zhong-Min
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics - pharmacology Analgesics - therapeutic use Animal models Animals Anti-inflammatory agents Biomedical and Life Sciences Biomedicine Cell Biology Cytokines Diabetes Diabetes mellitus Diabetic Neuropathies - drug therapy Diabetic Neuropathies - metabolism Diabetic neuropathy Drugs Enzyme-linked immunosorbent assay Glucosides - pharmacology Glucosides - therapeutic use HEK293 Cells Humans Inflammation Interleukin 1 Interleukin-1beta - genetics Interleukin-1beta - metabolism Neurochemistry Neurology Neurosciences Nociception Pain Pain perception Phenols - pharmacology Phenols - therapeutic use Proteomics Rats Rats, Zucker Receptors Receptors, Purinergic P2X7 - genetics Receptors, Purinergic P2X7 - metabolism Rodents Salidroside Sciatic nerve Sciatic Nerve - drug effects Sciatic Nerve - metabolism Spinal cord Spinal Cord - drug effects Spinal Cord - metabolism Tumor necrosis factor Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism
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